Change and continuity in neurobehavioral development: lessons from the study of neurobiology and neural plasticity

The goal of this paper is to discuss our current understanding of change and continuity in neurobehavioral development. After describing the basic elements of neurobiological development, attention is focused on the myriad of ways experience influences the developing and developed brain. This literature is used to illustrate the complexity of both brain and behavioral development in the context of change and continuity. The implications of considering brain/behavior relations in the context of development comprise the final section of the paper.     

Effects of motor-cognitive coordination training and cardiovascular training on motor coordination and cognitive functions

ObjectivesNumerous recent studies showed that physical training can enhance cognitive abilities, such as attention, spatial ability, memory performance, and executive functions. However, most of these studies focused on the efficiency of cardiovascular training, whereas evidence for combined motor-cognitive training emphasizing coordination abilities is scarce. Therefore, the aim of the present study was to investigate the effects of motor-cognitive coordination training and moderate cardiovascular training on cognitive functions and to test whether these effects were related to participant's fitness level.Design and methodWe tested 50 physically active (mean age = 23.5 years, SD = 3.2) and 56 sedentary participants (mean age = 23.4 years, SD = 3.2) in a pretest-training-posttest design with 12 sessions of moderate cardiovascular training (≈60% HRmax) or motor-cognitive coordination training. The training groups were compared to a passive control group. At pretest and posttest, participants performed an untrained motor-cognitive coordination task, measures of executive control (cognitive flexibility, inhibition, working memory), spatial ability, and fluid intelligence.Results and conclusionsWe found improved coordination abilities in the coordination training group, but no transfer of training to cognitive measures in physically active participants. However, sedentary participants showed larger improvements in terms of inhibition in the coordination training group compared to the remaining groups, while the cardiovascular training group improved in cognitive flexibility compared to the remaining groups. In sum, there are positive but differential effects of cardiovascular training and coordination training on cognitive performance in sedentary young participants, suggesting that coordination training may be a useful intervention especially for individuals that cannot perform cardiovascular training.     

Age-specific differences of dual n-back training

Age-related decline in executive functions can be decisive in performing everyday tasks autonomously. Working memory (WM) is closely related to executive functions, and training of WM has yielded evidence toward cognitive plasticity in older adults. The training effects often transfer to untrained tasks and functions. These effects have mostly been shown in processes such as WM and attention, whereas studies investigating transfer to executive functions have been scarce. We trained older adults aged 57–73 years in a WM training task that was reported to be effective in producing transfer in young adults. The training intervention consisted of a dual n-back task including independently processed auditory and visual n-back tasks. We investigated transfer to tasks engaging executive functions, and compared the effects in older adults to those reported in young adults. We found that both training groups improved in the training task. Although the training effect in older adults was smaller than the training effect in young adults, the older adults still showed a notable improvement so that after training they performed on the same level as young adults without training. The older adults also showed transfer to an untrained WM updating task, a result that was in accordance with the findings in young adults; other transfer effects in older adults were lacking. We conclude that although transfer effects were scarce, the present study provides encouraging evidence toward the possibilities to compensate for age-related decline in executive functions by a WM training intervention.     

The Map and the Territory: Complexity in Biology

In business administration or in economics it is absolutely relevant not to consider indexes like profit growth rate or gross domestic product as exhaustive indexes for economic wealth. Likewise, in biology it is important not to confuse the representation of life with life itself. The most important concepts in biology are information, memory, structure, plasticity, and robustness. Information is the difference that makes the difference. Memories are information registered in an organism. Plasticity is the capacity of a living organism to change its own structure/sets of behaviors for having a competitive advantage. Robustness is the ability of a living organism to resist environmental changes without changing its own structure/sets of behavior, and fragility is when a living organism undergoes changes in its own structure without being able to resist non-adaptive changes.     

Language learning impairment: Integrating research and remediation

Timing cues present in the acoustic waveform of speech provide critical information for the recognition and segmentation of the ongoing speech signal. Research has demonstrated that deficient temporal perception rates, that have been shown to specifically disrupt acoustic processing of speech, are related to specific language-based learning impairments (LLI). Temporal processing deficits correlate highly with the phonological discrimination and processing deficits of these children. Electrophysiological single cell mapping studies of sensory cortex in brains of primates have shown that neural circuitry can be remapped after specific, temporally cohesive training regimens, demonstrating the dynamic plasticity of the brain. Recently, we combined these two lines of research in a series of studies that addressed whether the temporal processing deficits seen in LLIs can be significantly modified through adaptive training aimed at reducing temporal integration thresholds. Simultaneously, we developed a computer algorithm that expanded and enhanced the brief, rapidly changing acoustic segments within ongoing speech and used this to provide intensive speech and language training exercises to these children. Results to date from two independent laboratory experiments, as well as a large national clinical efficacy trial, demonstrate that dramatic improvements in temporal integration thresholds, together with speech and language comprehension abilities of LLI children, results from training with these new computer-based training procedures.     

Bidirectional Associations between Parenting Practices and Conduct Problems in Boys from Childhood to Adolescence: The Moderating Effect of Age and African-American Ethnicity

This study examined the bidirectional relationship between parent and teacher reported conduct problems in youth and parenting practices using a longitudinal sample of boys assessed from 6 to 16 years of age. Analyses tested whether these bidirectional associations changed across development and whether the nature of these associations varied across African-American and Caucasian families. Overall, the results supported a bidirectional relationship between conduct problems and all parenting practices examined from childhood to adolescence. The influence of conduct problems on changes in parenting behaviors was as strong as the influence of parenting behaviors on changes in conduct problems across development. Changes in the bidirectional relationship across development were found in some, but not all, models. While corporal punishment was more strongly related to changes in teacher-reported conduct problems for African-American boys compared to Caucasian boys, more similarities than differences were found between the ethnic groups in terms of the bidirectional associations examined.     

IMPLICATIONS OF INTERPERSONAL NEUROBIOLOGY FOR A SPIRITUALITY OF COMPASSION

Interpersonal neurobiology (IPNB) is a burgeoning interdisciplinary field that focuses on ways in which relationships shape and transform the architecture and functioning of the human brain. IPNB points to four specific conditions that appear to encourage the emergence of empathy. Further, these conditions, when gathered together, may constitute the core components of a spirituality of compassion. Following definitions and a discussion of interdisciplinary method, this essay delineates IPNB's main tenets and demonstrates ways in which IPNB sheds light on important aspects of human empathy and compassion. Drawing on this analysis, it introduces the four conditions that encourage the emergence of empathy in individuals and groups and shows why they may be central elements of a spirituality of compassion. A case study, in which the Native American Ojibwe practice of the talking circle is described and assessed through the lens of the IPNB‐derived spirituality of compassion, demonstrates the evaluative usefulness of this set of conditions.     

Contributions of Neuroscience to Our Understanding of Cognitive Development

ABSTRACT— One major contribution of neuroscience to understanding cognitive development has been in demonstrating that biology is not destiny—that is, demonstrating the remarkable role of experience in shaping the mind, brain, and body. Only rarely has neuroscience provided wholly new insights into cognitive development, but often it has provided evidence of mechanisms by which observations of developmental psychologists could be explained. Behavioral findings have often remained controversial until an underlying biological mechanism for them was offered. Neuroscience has demonstrated promise for detecting cognitive problems before they are behaviorally observable—and, hence, promise for early intervention. In this article, we discuss examples drawn from imitation and mirror neurons, phenylketonuria (PKU) and prefrontal dopamine, maternal touch and stress reactivity, and nongenetic (behavioral) intergenerational transmission of biological characteristics.     

NMDA受体的结构与药理学特性

NMDA受体是一类离子型谷氨酸受体,其功能主要参与发育过程中神经回路的细化及触发多种形式的突触可塑性。近年来的证据表明,组成NMDA受体的亚单位有着复杂的生理学和药理学特性;NMDA受体的数量、分布和亚单位组成并非一成不变,而是在发育过程中、神经元活动时,以一种细胞特异性和突触特异性的方式变化着。这种NMDA受体的双向变化是突触可塑性重塑的基础,而其调节的异常又可导致神经-精神疾病的发生,如可卡因成瘾、精神分裂症等