从系统论分析慢性炎症向肿瘤的恶性转化

慢性炎症相关肿瘤疾病,其机制涉及到的不再是个别的基因产物或蛋白分子,也不再是单一的信号通路或代谢途径,而是众多的基因、蛋白质和代谢小分子等各种生物分子构成的复杂的调控网络。这一网络中的相互联系、动态以及突变特性,要求运用系统论的方法来分析。这种分析将拓展临床医生的研究思路,推动对炎症向肿瘤转化本质的认识。     

Cognitive-behavioral therapy of insomnia: A clinical case series study of patients with co-morbid disorders and using hypnotic medications

Cognitive-behavioral therapy for insomnia (CBTi) has demonstrated considerable efficacy within randomized clinical trials and case-series designs. This case-series study in a community sleep medicine clinic assessed the effectiveness of an eight-session CBTi protocol chronic insomnia patients who were allowed to continue their use of hypnotics (intent-to-treat n = 48), administered by a clinical psychology doctoral student receiving training and supervision in CBTi by a behavioral sleep medicine certified clinician. Outcome measures included daily sleep diaries, self-report measures on insomnia severity, dysfunctional beliefs and attitudes about sleep, daytime sleepiness, as well as medication usage. Patients showed significant improvements in sleep onset latency, wake time after sleep onset, sleep efficiency, insomnia severity, and dysfunctional sleep beliefs from pre- to post-treatment. No changes were seen in daytime sleepiness - patients were not excessively sleepy either before or after treatment. Use of sleep medication declined significantly from 87.5% pre-treatment to 54% post-treatment, despite no active efforts to encourage patients to withdraw. Results demonstrate that a CBTi conducted in a community sleep medicine clinic with patients not required to discontinue sleep-related medications can have similar effects as therapy delivered among those not on medication.     

颜色知觉突显对预览效益的影响

本研究通过预览搜索范式考察靶子在颜色高突显情况下的预览效益,探讨其优先选择机制。结果发现在靶子颜色高突显的情况下,预览效益没有出现,说明预览效益的出现有其一定的条件和限制,并为基于刺激特征的抑制的解释提供了支持证据。本文还探讨了预览效益消退的可能原因。     

On the Observability of Purely Behavioral Sunk-Cost Effects: Theoretical and Empirical Support for the BISC Model

There is growing interest in whether and how sunk-cost effects for purely behavioral investments occur. In this article, we further discuss Cunha and Caldieraro's (2009) Behavioral Investment Sunk Cost (BISC) model and reconcile Otto's (2010) results with the BISC model predictions. We also report new data from two unpublished experiments that are consistent with the BISC model, and we discuss the conditions under which purely behavioral sunk-cost effects are likely to be observed.     

Vigilant Self‐regulation and Costly Punishment in Public Goods Situations

Applying regulatory focus theory to the context of social dilemma situations, the present research demonstrates that individual differences in vigilant, prevention‐focused self‐regulation predict the tendency to invest private resources to punish uncooperative interaction partners (costly punishment), a behaviour that typically has strong positive effects on the collective level of cooperation. Analyses further support the distinctiveness of the vigilance system proposed in regulatory focus theory (prevention focus) in comparison with general defensive inhibitory tendencies (measured with Carver and White's Behavioral Inhibition System scale). Results document that individual differences in prevention‐focused self‐regulation but not differences in general defensive inhibitory tendencies are positively related to costly punishment. In sum, the findings indicate that vigilant, prevention‐focused self‐regulation plays a crucial role in the context of sanctions that enforce cooperation. Copyright © 2013 John Wiley & Sons, Ltd.     

Selling the War? System‐Justifying Effects of Commercial Advertising on Civilian Casualty Tolerance

In times of war, news media coverage of the plight of civilian casualties plays a critical role in shaping attitudes regarding war's human costs. We proposed that these attitudes may also be surreptitiously influenced by the commercial advertisements that often accompany this coverage. Specifically, we hypothesized that when newspaper articles pertaining to civilian victims of war are flanked by luxury ads, conservatives, relative to liberals, will subsequently exhibit less concern for these victims. This proposition was based on the notion that commercial ads, particularly those promoting luxury items, make salient the gap between the “haves” and the “have‐nots” and thereby, at least implicitly, threaten the legitimacy of the current socioeconomic system. Drawing upon system justification theory, we posited that this threat would lead individuals with stronger system‐justification tendencies (conservatives), relative to those more open to challenging the current system (liberals), to show greater tolerance for civilian war casualties in order to defend the system's integrity. Evidence consistent with this hypothesis was found in a quasi‐experimental study (n = 329).     

Numerical approximation abilities correlate with and predict informal but not formal mathematics abilities

Previous research has found a relationship between individual differences in children’s precision when nonverbally approximating quantities and their school mathematics performance. School mathematics performance emerges from both informal (e.g., counting) and formal (e.g., knowledge of mathematics facts) abilities. It remains unknown whether approximation precision relates to both of these types of mathematics abilities. In the current study, we assessed the precision of numerical approximation in 85 3- to 7-year-old children four times over a span of 2 years. In addition, at the final time point, we tested children’s informal and formal mathematics abilities using the Test of Early Mathematics Ability (TEMA-3). We found that children’s numerical approximation precision correlated with and predicted their informal, but not formal, mathematics abilities when controlling for age and IQ. These results add to our growing understanding of the relationship between an unlearned nonsymbolic system of quantity representation and the system of mathematics reasoning that children come to master through instruction.     

Neuroticism,BIS, and reactivity to discrete negative mood inductions

Research has established relationships between the personality dimensions of neuroticism and BIS and broad negative emotional reactivity. However, few researchers have examined the relationships among neuroticism, BIS, and discrete negative emotional reactivities. The present study examined whether individuals scoring high on neuroticism and BIS were more reactive across four discrete negative mood inductions, relative to those scoring low on these traits. Participants (n = 166) completed personality questionnaires, measures of current mood, viewed a specific mood-inducing film clip (sadness, anger, fear or disgust) and then reported their moods a second time. Results revealed that neuroticism/BIS was associated with high reactivity to the fear and sadness inductions. Neuroticism/BIS did not predict anger or disgust reactivity, but neuroticism/BIS and extraversion/BAS interacted in predicting anger. Although further research is needed to extend generalizability, it appears that neuroticism and BIS predict negative emotional reactivity broadly, but not ubiquitously.     

Advanced Brief Strategic Therapy: An overview of interventions with eating disorders to exemplify how theory and practice work

This paper aims at introducing some of the central aspects of the evolution that brief strategic therapy has undergone at the Centro di Terapia Strategica of Arezzo, Italy, towards advanced therapeutic strategies which differ from the original Palo Alto model. (Fisch, Weakland, &; Segal, 1982; Watzlawick, 1978 Watzlawick, P. 1978. The language of change: Elements of therapeutic communication, New York: Basic Books.  [Google Scholar]; Watzlawick, Beavin, &; Jackson, 1967; Watzlawick, Weakland, &; Fisch, 1974). We will focus on how the concept of self-deception is central to the formation and the persistence of psychological disorders; and how the usage of non-ordinary logics and the understanding of the individual's perceptive-reactive system are of key importance in unravelling such disorders, allowing the therapist to guide the patient towards an efficacious and efficient solution. Rather than attempting to describe and enlist the theoretical corpus that underlies brief strategic therapy, we have chosen to exemplify some focal concepts that connect theory to practice, and vice versa, by presenting the outline of some therapeutic protocols devised for solving eating disorders which can be specifically tailored for each individual patient.     

Deep structure,cognition and rebirth: Propositions for viability and vitality in human systems

This paper describes systems dynamics related to deep structure and development processes in human systems, to the process of arresting entropy or premature death in these systems and to the relationship between the cognition of deep structure, its outward manifestation and human systems viability and vitality. The paper proposes that inherent forces are present in systems that act to bring about alignment between inner deep structure and a system's manifested outer structures and processes, thereby enhancing viability and vitality. Deep structure is seen as a force toward self‐organization and rebirth.