人类行为遗传学的伦理问题

行为遗传学是试图定位与行为特性有关的特殊基因或基因组及了解基因与环境之间复杂关系的一种研究.行为遗传学是研究正常范围内的非病理变化,与人类疾病遗传学存在差异.行为遗传学研究面临许多伦理学问题,诸如,智力的遗传性,基因能否决定一切,生物社会学与人类文化评估,生命伦理学与行为遗传学的关系等,因此,对行为遗传学研究结果的阐述必须十分谨慎.     

农村选民选举行为的结构特征

以云南省两个县八个自然村的 2 62名选民为被试 ,采用心理测量原理与技术探讨了农村选民选举行为的结构特征。结果表明 ,政见取向由“政策效应”、“民生意识”、“村民权益”和“监督机制”4个因素构成 ,非政见取向由“候选人身份”、“候选人德能”、“选民社会关系”、“候选人背景”、“选民自我利益”、“选民自我权利”和“政党意见”7个因素构成。经检验 ,由此构成的农村选举行为问卷具有较高的内部一致性 ,问卷项目具有较高的区分度。文章讨论了农村选民选举行为的结构特征及其意义。     

The revised perceived locus of causality in physical education scale: Psychometric evaluation among youth

Objectives

Given instances of less than optimal internal consistency levels of the Perceived Locus of Causality (PLOC) scale when applied to school-based physical education (PE), the aim of the study was to examine the psychometrics of a revised PLOC instrument for use in PE.

Design

A cross-sectional study in which self-report data on behavioral regulations, perceived autonomy support by the PE teacher, and subjective vitality were collected from 1729 students in relation to their PE participation at the elementary school (5th and 6th grade), middle school, and high school levels, including boys and girls.

Results

The revised instrument (PLOC-R) demonstrated satisfactory levels of internal consistency; a sound factor structure; evidence in support of a simplex-like structure; configural, metric, strong, and strict measurement invariance across boys and girls, students who participate or not in out-of-school sport activities, and across the three school grade levels; and nomological validity.

Conclusions

Initial evidence has emerged in favor of the PLOC-R as a scale appropriate for use with 5th and 6th grade elementary, middle school, and high school students to measure the degree of self-determined motivation for participation in compulsory school-based physical education classes.     

心理账户:缘起、理论及应用

心理账户深刻地体现了心理学和经济学的结合,是在行为经济学的大背景下开始研究的。心理账户是人们在心理上对结果,尤其是经济结果的编码,分类和估价的过程,它反映了人们在进行资金财富决策过程中的心理认知过程。心理账户与经济账户的运算法则不同,它具有非替代性。心理账户与金融投资结合形成了行为资产组合理论,心理账户与消费经济结合,形成了行为生命周期理论。     

Brazelton Neonatal Behavioral Assessment Scale: A psychometric study in a Portuguese sample

BackgroundThe Neonatal Behavioral Assessment Scale (NBAS, Brazelton &; Nugent, 1995) is an instrument conceived to observe the neonatal neurobehavior. Data analysis is usually performed by organizing items into groups. The most widely used data reduction for the NBAS was developed by Lester, Als, and Brazelton (1982).ObjectiveExamine the psychometric properties of the NBAS items in a sample of 213 Portuguese infants.MethodThe NBAS was performed in the first week of infant life (3 days ± 2) and in the seventh week of life (52 days ± 5).ResultsPrincipal component analyses yielded a solution of four components explaining 55.13% of total variance. Construct validity was supported by better neurobehavioral performance of 7-week-old infants compared with 1-week-old infants.ConclusionChanges in the NBAS structure for the Portuguese sample are suggested compared to Lester factors in order to reach better internal consistency of the scale.     

On the Observability of Purely Behavioral Sunk-Cost Effects: Theoretical and Empirical Support for the BISC Model

There is growing interest in whether and how sunk-cost effects for purely behavioral investments occur. In this article, we further discuss Cunha and Caldieraro's (2009) Behavioral Investment Sunk Cost (BISC) model and reconcile Otto's (2010) results with the BISC model predictions. We also report new data from two unpublished experiments that are consistent with the BISC model, and we discuss the conditions under which purely behavioral sunk-cost effects are likely to be observed.     

基因多态性对情绪调节神经回路的影响

随着脑成像和基因分析等新技术手段的综合运用, 情绪调节的神经生物学基础研究有了很大进展。综述相关研究表明: 情绪调节的神经回路涉及背侧-腹侧前额叶、前额叶-杏仁核和皮层-边缘系统的相互作用, 这些神经回路受到5-羟色胺传运体(5-hydroxytryptamine transporter, 5-HTT)、儿茶酚转甲酶 (Catechol-O-methyltransferase, COMT)和色氨酸羟化酶2(Tryptophan hydroxylase 2, TPH2)等基因变异, 以及不同基因多态之间交互作用的影响。情绪调节神经回路的功能出现障碍将导致情绪疾病的产生。     

Preventing HIV infection in heterosexual women: What do we know? What must we learn?

Women are becoming infected with HIV via heterosexual activity at an accelerating rate, both in the United States and globally. Although a number of evaluations of behavioral risk-reduction interventions for women have been reported, many suffer from methodological problems that weaken confidence in their findings, and furthermore it is clear that many women are unable to respond to the interventions that have been tested. Most women infected through heterosexual activity are infected by their primary partner, yet achieving consistent condom use with this partner can be highly challenging for women. The present article presents recent work and innovative ideas for intervention strategies that may be more feasible, and thus more effective, for women at risk for HIV infection by their primary male partner.     

反社会行为潜在遗传因素的全基因组关联分析

反社会行为是一种受基因和环境共同影响的复杂性行为, 但单个基因如单胺氧化酶基因(MAOA)、5-羟色胺转运体启动因子基因(5-HTT)、儿茶酚-o-甲基转移酶(COMT)基因的影响并不能全面解释其产生的分子遗传机制。来自分子遗传学研究取向的方法—— 全基因组关联分析(genome-wide association study, GWAS), 把人类基因组中数以百万计的单核苷酸(SNPs)和复制数变异(CNVs)作为遗传标记, 在全基因组层面上, 开展多中心、大样本的关联研究, 经过反复验证来发现与外在表型相关的基因位点, 为进一步了解反社会行为复杂分子遗传机制提供了重要的线索。未来的研究应该通过科学的实验设计将精确的基因分型技术与心理、环境因素相结合, 实现对复杂性行为或特质的基因-心理-环境模型的成因性分析。     

非药物成瘾的遗传学和神经生物学机制研究述评

非药物成瘾又称“非物质相关性成瘾”或“行为成瘾”。特征性表现包括对成瘾对象的渴望、受损的冲动控制、对成瘾对象的耐受、撤退反应和高复发率等。目前发现的非药物成瘾类型包括病理性赌博、网络成瘾、购物成瘾、游戏成瘾、性瘾以及贪食等。非药物成瘾与药物成瘾在症状学上表现出很高的相似性且具有较高的共病率, 提示二者之间可能存在着共同的发病机制。从遗传学和神经生物学的角度探讨非药物成瘾的机制具有重要的理论价值和临床应用价值。家庭研究和双生子研究发现, 男性的病理性赌博和贪食障碍具有中度以上的遗传度。分子遗传学研究发现, 单胺能神经递质相关基因, 如5-羟色胺转运体基因、多巴胺受体基因和单胺氧化酶A基因等, 与非药物成瘾有关。神经影像学研究发现, 非药物成瘾者脑内负责奖赏,线索加工和冲动控制的神经通路活动性异于正常对照。未来研究需要进一步从多个角度入手, 探讨非药物成瘾与药物成瘾的共性和特性。