Lateral asymmetries in the naming of words and corresponding line drawings

Laterally displaced line drawings and the words which name these drawings were tachistoscopically presented to adult subjects. For words, as expected, a right visual field-left hemisphere advantage was obtained. For line drawings, in contrast to previous studies which have typically reported a right visual field-left hemisphere advantage, no visual field asymmetry was found. The absence of a visual field asymmetry for line drawings is consistent with reports of a shift toward greater right hemisphere involvement in the recognition of pictographic as compared to phonetic writing systems and concrete/imageable words as compared to abstract/nonimageable words. Further, the present results seem consistent with findings on picture recognition and naming abilities in brain-damaged patients.     

A parent-offspring adoption study of cognitive abilities in early childhood

Do cognitive abilities in early childhood relate genetically and/or environmentally to isomorphic abilities in adulthood? Are specific cognitive abilities diffentiated in early childhood in terms of their prediction of adult cognitive abilities? The present study, the first behavioral genetic analysis of specific cognitive abilities in early childhood, explored these questions using parent-offspring data for 186 adopted children and 151 nonadopted children tested in the longitudinal Colorado Adoption Project at 3 years of age and 162 adopted children and 138 nonadopted children tested at 4 years. The children's Stanford-Binet IQ and scores for four specific cognitive abilities (verbal, spatial, perceptual speed, and memory) were correlated with corresponding measures for their parents—the biological and adoptive parents of the adopted children and the natural parents of the nonadopted children. Significant correlations were found between biological mothers' IQ and the IQ of their adopted away offspring at 3 and 4 years of age, suggesting genetic influence for IQ. However, specific cognitive abilities yielded no significant correlations between biological mothers and their adopted-away offspring. These results suggest that substantial genetic continuity exists for IQ from early childhood to adulthood, but not for specific cognitive abilities.     

How,and for whom,will activity patterns be modified by self-driving cars? Expectations from the state of Georgia

Many studies have explored travelers’ perceptions of self-driving cars (or autonomous vehicles, AVs) and their potential impacts. However, medium-term modifications in activity patterns (such as increasing trip frequencies and changing destinations) have been less explored. Using 2017–2018 survey data collected in the US state of Georgia, this paper (1) measures (at a general level) how people expect their activity patterns to change in a hypothetical all-AV era; (2) identifies population segments having similar profiles of expected changes; and (3) further profiles each segment on the basis of attitudinal, sociodemographic, and geographic characteristics. In the survey, respondents were asked to express their expectations regarding 16 potential activity modifications induced by AVs. We first conducted an exploratory factor analysis (EFA) to reduce the dimensionality of the activity-change vector characterizing each individual, and estimated non-mean-centered (NMC) factor scores (which have been rarely used in applied psychology). The EFA solution identified four dimensions of activity change: distance, time flexibility, frequency, and long distance/leisure. Next, we clustered Georgians with respect to these four-dimensional expectation vectors. The cluster solution uncovered six segments: no change, change unlikely, more leisure/long distance, longer trips, more travel, and time flexibility & more leisure/long distance. Using NMC factor scores identified considerably more inertia with respect to expectations for change than would have been apparent from the usual mean-centered scores. Finally, the various segments exhibit distinctive demographics and general attitudes. For example, those in the more leisure/long distance cluster tend to be higher income and are more likely to be Atlanta-region residents compared to other clusters, while those in the no change and change unlikely clusters tend to be older and are more likely to be rural residents.     

Special Considerations in the Adaptation of Cognitive Behavioral Therapy for Insomnia With Active-Duty U.S. Army Personnel

Insomnia is highly prevalent among active-duty military service members. Cognitive Behavioral Therapy for Insomnia (CBT-I) is a well-established and effective treatment; however, research and treatment recommendations have primarily focused on civilian or veteran populations. A multitude of military-specific factors directly impact service members’ sleep and the subsequent treatment recommendations. This article provides treatment considerations for the use of CBT-I with active-duty U.S. Army personnel. First, an overview of the theoretical model of insomnia, including military-specific predisposing, precipitating, and perpetuating factors, is presented, followed by a review of common comorbid conditions among service members with insomnia. Finally, discussion focuses on considerations and strategies for implementing components of CBT-I with service members, managing sleep during deployments, and adjusting sleep to accommodate overnight duties. Additional training resources and supplemental video examples (with actors) are provided.     

Adaptive warning signals adjusted to driver passenger conversation: Impact of system awareness on behavioral adaptations

The study investigated behavioral adaptation caused by warning signals that adaptively support drivers engaged in a passenger conversation. Novel advanced driver assistance systems (ADAS) could monitor the driver state to provide warnings adjusted to the driver’s current need for support. While first research indicates positive effects of dynamically adjusting ADAS, the overall safety potential of such adaptive systems remains unclear as little is known about adverse behavioral effects. Occasional inappropriate support due to an incorrect prediction of the current driver state might lead to critical situations when drivers are aware of the adaptive nature of the system and thus rely on the expected system behavior. To better understand behavioral adaptation to dynamically adjusting warnings, 46 participants driving on a test track reacted to two types of warnings (auditory, vibrotactile-auditory) while engaging in driver-passenger conversation or not. In a compensating warning strategy, vibrotactile-auditory warnings were displayed during conversations and auditory warnings in situations without conversation. This strategy was compared to a non-compensating warning strategy in which these assignments were reversed. The impact of behavioral adaptation was measured by considering reactions to simulated failures of these strategies. The role of system awareness for behavioral adaptation was investigated by manipulating awareness of these warning strategies across groups. We found that vibrotactile-auditory warnings reduced the detrimental effects of conversation on reaction times. Crucially, adverse behavioral adaptation was observed whenever an expected vibrotactile-auditory warning was replaced by an auditory warning but this effect was restricted to drivers in the awareness group. The results show that adaptive warning signals optimize the effectiveness of warnings during driver-passenger conversation but adverse behavioral adaptation develops when drivers are aware of the underlying warning strategy. This implies that future adaptive systems are less likely to be associated with behavioral adaptation if the adaptive nature of the system remains unnoticeable to the driver. Our findings could be used for developing and optimizing user-centered ADAS.     

多巴胺系统基因对注意网络的调控作用

多巴胺是脑内重要的神经递质之一,与注意活动紧密相关。本文选取作用于突触前膜、间隙和后膜的多巴胺系统基因——多巴胺转运蛋白基因、儿茶酚氧化甲基转移酶基因和多巴胺受体基因,整合影像遗传学研究,探讨多巴胺基因对注意网络的调控。元分析发现背侧和腹侧注意网络的主要脑区均有较大的基因调控效应,且腹侧网络的效应值显著大于背侧网络,表明多巴胺系统基因在全脑范围内调控注意网络,且对腹侧网络的调控作用更强于背侧网络。     

Genetic Studies of Autism: From the 1970s into the Millennium

Reviewers in the 1960s and early 1970s were skeptical about any substantial role for genetic factors in the etiology of autism. A realization that the 2% rate of autism in siblings (as estimated at that time) was far above the general population base rate, and that this suggested a possible high genetic liability, led to the first small-scale twin study of autism. The replicated evidence from both twin and family studies undertaken in the 1970s and 1980s indicated both strong genetic influences and the likelihood that they applied to a phenotype that was much broader than the traditional diagnostic category of autism. Medical and chromosomal findings also indicated genetic heterogeneity. Advances in molecular genetics led to genome-wide scans of affected relative pair samples with a positive log of the odds to base 10 score for a location on chromosome 7. The major remaining research challenges and the likely clinical benefits that should derive from genetic research are considered in relation to both current knowledge and that anticipated to emerge from research over the next decade.     

医学遗传服务与遗传学研究的伦理问题

遗传工程的分子技术于本世纪７０年代问世。这一技术的创新使人类与医学遗传学突飞猛进,由此导致遗传医学的飞速发展。与此同步,医学伦理学兴起,临床医学遗传服务与遗传学研究的伦理问题日益成为人文科学关注的核心。世界卫生组织（ＷＨＯ）于１９９７年发布的《医学遗传学与遗传服务伦理问题的建议国际准则》。探讨我国医学伦理学发展的策略和面临的挑战,祈盼适合我国国情的中华医学遗传服务与遗传学研究的伦理准则早日问世。     

Schizophrenia Epigenesis?

I begin by examining how genetics drivesschizophrenia research, and raise both familiar andrelatively novel criticisms of the evidence putativelysupporting the genetic basis of schizophrenia. Inparticular, I call attention to a set of concernsabout the effects of placentation on concordance ratesof schizophrenia in monozygotic twins, which furtherweakens the case for schizophrenia's so-called stronggenetic component. I then underscore two criticalpoints. First, I emphasize the importance of takingseriously considerations about the complexity of bothontogenesis and the development of hereditarydiseases. The recognition of developmentalconstraints and supports is crucial, for attention todevelopment exposes the naivete of too many models ofgene action in the aetiology of disease. Secondly, Iattend to those schizophreniologists who ignoremethodological criticisms and thus presume a geneticbasis for schizophrenia, and then seek the schizophrenic genotype lacking an adequatephenotype. In response I attempt to demonstrate thenecessity of a sustained effort at characterizing thephenotype of schizophrenia as an enabling conditionfor the whole enterprise of psychiatric genetics – andfor psychiatry itself. Without the organism-levelphenotype, research at the level of genes will remainunproductive – assuming of course that research at thegenetic level is appropriate at all.