Multimodal assessment of disgust in contamination-related obsessive-compulsive disorder

The present study utilizes multiple methods to examine the relationship between disgust and contamination-related obsessive-compulsive disorder (OCD) symptoms in an analogue sample. Questionnaire findings revealed that participants with high OCD contamination concerns showed stronger disgust sensitivity than did participants with low OCD contamination symptoms after controlling for negative affect. High OCD participants (N=30) also reported significantly more disgust than did low OCD participants (N=30) when exposed to a disgust-inducing video, whereas no significant between-group differences were detected on other negative emotional dimensions. Results from a series of disgust-specific behavioral avoidance tasks (BATs) revealed that high OCD participants demonstrated both less compliance and less approach behavior. Subsequent analysis also revealed that disgust sensitivity generally mediated avoidance on the BATs among high OCD subjects. High OCD participants also rated the BATs as more fearful and disgusting than did low OCD participants, with disgust generally emerging as the dominant emotional response. The results are consistent with a disgust-based, disease-avoidance approach in understanding contamination-related OCD themes.     

“To eat or not to be eaten?” Collective risk-monitoring in groups

The importance of risk-monitoring has been increasing in many key aspects of our modern lives. This paper examines how individuals monitor such risks collectively by extending a behavioral ecological model of animal foraging to human groups. Just as animals must forage for food under predatory risk, humans must divide valuable material and psychological resources between foraging activity and risk-monitoring activity. We predicted that game-theoretic aspects of the group situation complicate such a trade-off decision in resource allocation, eventually yielding a mixed equilibrium in a group. When the equilibrium is reached, only a subset of members engage in the risk-monitoring activity while others free-ride, concentrating mainly on their own foraging activity. Laboratory groups engaging in foraging under moderate risk provided a support to this prediction. When the risk-level was set higher, however, “herding behavior” (conforming to the dominant behavior) interfered with the emergence of equilibrium. Implications for risk management are discussed.     

Comparing Brief and Extended Wait-Time During Small Group Instruction for Children with Challenging Behavior

This preliminary study compared brief (1 s) and extended (4 s) wait-time on response opportunities, academic responses, accuracy, and disruptive behavior of two children with challenging behavior during small group instruction. Brief wait-time increased children’s response opportunities, academic responses, and accuracy in comparison to extended wait-time. Though variable, brief wait-time also decreased children’s disruptive behavior. Findings differ from previous research, which found performance improvements with extended wait-time for children with moderate to profound cognitive disabilities. Limitations of the study and future research suggestions are discussed.     

Successful Use of Peer Educators for Sharing Genetic Information

This study examined the impact of a genetics education module provided by Reach to Recovery peer volunteers. Participants included 113 women with confirmed breast cancer diagnoses. Eighty-eight of these women (78%) completed a baseline survey, participated in a peer-led intervention, and completed a follow-up survey. Approximately half of the women received an education module that included a genetic component, while the other half did not. Results indicated that women who received the genetics module had greater increases in genetics knowledge than the group that did not receive the module. However, follow-up interest in genetic testing was not significantly different between the two groups. Results indicate that a peer-led genetics module can increase knowledge about genetics. However, it does not appear to have a differential effect on genetic testing interest.     

Using the Millon Behavioral Medicine Diagnostic to Delineate Treatment Outcomes in Rehabilitation

Patients undergoing rehabilitation have been evidenced to improve in different ways depending on their coping styles. Amplifiers, Repressors, and Social Copers are examples of patients who present differently in rehabilitation settings and tend to have differing levels of success in their response to treatment. The current study examined the differential treatment outcomes of three coping style groups undergoing multidisciplinary rehabilitation. A sample of 59 patients suffering from injuries associated with chronic pain were assessed using the Multidimensional Pain Inventory, Beck Depression Inventory, and Beck Anxiety Inventory before, during, and after multidisciplinary pain management treatment. Coping style groups derived from the Millon Behavioral Medicine Diagnostic consisting of Amplifiers, Repressors, and Social Copers were compared with regard to reductions in depression, anxiety, pain, functional impairment, and associated outcomes. Repeated measures ANOVA revealed that Amplifiers, Repressors, and Social Copers had varying levels of success in the treatment program. Hierarchical linear modeling analyses revealed the coping style groups to have significantly different change curves from pre to post-treatment in depression, anxiety, pain severity, functional impairment, affective distress, life control, social support, and soliciting help from others. These findings support prior research emphasizing the value of tailoring treatments in rehabilitation settings toward patients’ coping styles in order to maximize outcomes. A program (provided in either SAS or SPSS syntax) that will compute MBMD coping style group membership will be provided upon request. Request by e-mail to: dcipher@hsc.unt.edu or by fax to: +1-817-7352270.     

儿童2～7岁行为抑制性发展对7岁时问题行为、学校适应的预测作用

本研究采用陌生实验室的录像观察考察了中国2~7岁儿童行为抑制性的发展,并且采用教师评价量表报告了儿童7岁时的学校适应,采用父母填写儿童行为调查表CBCL来测查儿童7岁时的问题行为,从而考察了儿童2~7岁的行为抑制性对其7岁时的问题行为和学校适应的预测作用。儿童2岁时,共有208名儿童参加了这项追踪研究,4岁时,由于被试拒绝参加、搬家或失约,共有176名儿童参加了实验室的录像观察。7岁时,共有124名儿童参加了实验室实验和学校教师的评价,并且父母对7岁儿童的问题行为进行了报告。同时参加2、4、7岁研究的儿童为66人,其中男孩为28人,女孩38人。协方差结构模型分析表明:儿童2岁时的抑制性水平越高,7岁时的学习问题越少;儿童4岁时的抑制性水平越高,7岁时的攻击行为越少,挫折耐受力、任务定向能力越强,但同时抑郁问题也越多。而7岁时的抑制性可以边缘显著地预测儿童7岁时母亲所报告的退缩问题,即7岁时抑制性水平越高,母亲所报告的退缩问题越多。而且,本研究还发现女孩7岁的抑制性水平越高,任务定向能力和果断的社交技能越差。男孩2岁的抑制水平越高,任务定向能力越强;男孩7岁时抑制水平越高,攻击行为越多。     

联合常规细胞遗传学技术、多重巢式聚合酶链反应技术检测120例急性白血病患者遗传学异常

探讨如何提高急性白血病患者染色体／特异融合基因异常的检出率与准确率。联合常规细胞遗传学技术、多重巢式聚合酶链反应技术对120例急性白血病患者进行检测。结果表明：应用常规细胞遗传学检测出82例核型异常,占68．3％,而应用多重巢式聚合酶链反应技术检测出54例融合基因异常,占45％。联合这两种技术,120例急性白血病患者的遗传学异常检出率为：75％（90／120）,其中有65例明确了具体染色体改变或特异性融合基因异常。30例患者经常规细胞遗传学检测出具有t（8;21）（q22;q22）或t（15;17）（q22;q12）,多重巢式聚合酶链反应技术检测出39例患者具有AML1／ETO、PML／RARA或CBFB／MYH11融合基因异常。当存在染色体数目异常,或者不存在19种融合基因之一时多重巢式聚合酶链反应结果为阴性。提示常规细胞遗传学技术联合多重巢式聚合酶链反应技术可以有效地提高急性白血病患者染色体异常／特异性融合基因的检出率。     

A model of working memory capacity in the radial-arm maze task

The radial arm maze is one of the most commonly used tests for assessing working memory in laboratory animals. However, to date, there exists no quantitative method of estimating working memory capacity from performance on this task. Here, we present a mathematical model of performance on the radial arm maze from which we can derive estimates of capacity. We derive explicit results for the two most commonly used measures of performance as functions of number of arms in the maze and memory capacity, assuming a uniform random search. We simulate random non-uniform search strategies. Comparing our model to previous experiments, we show that our model predicts a working memory capacity in the range of 3-9 at the level of performance observed in these experiments. This estimate is within the typical estimate of human working memory capacity. Performance of rats on large mazes (e.g. 48 arms) has been used as evidence that the working memory capacity of rats may be significantly larger than that of humans. We report that memory capacity in the range 3-9 is sufficient to explain the performance of rats in very large radial mazes. Furthermore, when we simulate non-uniform random search strategies observed in the experiments, the resulting estimates do not differ significantly from those assuming a uniform random search. We conclude that a list-based model of working memory with modest capacity is more powerful than previously expected.     

Specificity of cognitive and behavioral variables to Positive and Negative Affect

The Tripartite Model proposes that a combination of greater Negative Affect (NA) and reduced Positive Affect (PA) contributes to depressive symptoms. The purpose of this study was to test a model of affective experience in which cognitive variables (i.e., negative cognitions and appraisals) are uniquely related to NA but not PA, and in which behavioral variables (i.e., activity participation) are uniquely associated with PA but not NA. Participants included 88 spousal Alzheimer caregivers (mean age = 74 years). Multiple regression models, in which negative cognitions (i.e., helplessness, blames self, and negative appraisals) and activity participation (i.e., frequency of engaging in social and recreational activities) were used to predict depressive symptoms, PA and NA. Results indicated that while helplessness, blaming oneself, negative appraisals, and activity participation all significantly predicted depressive symptoms, only negative cognitive variables significantly predicted NA, and only activity participation significantly predicted PA. These data confirm that depressive experience consists of two relatively independent components - increased Negative Affect and reduced Positive Affect - which have unique correlates in negative cognitions and activity participation. If confirmed, the findings suggest the utility of focusing interventions on each of these components in the management of depressive symptoms.     

The embodied self: thinking psychoanalytically in a time of 'science'

Abstract :  In order to be relevant in our 'scientific' times, it is necessary that we psychoanalysts situate our ideas in thoughtful and respectful relationship to neighbouring disciplines such as genetics, cultural studies, and neuro-anatomy. In this paper I suggest that, although psychoanalysis still continues to have valuable contributions to make to the understanding of human sexual experience and behaviour, in order to make these contributions relevant we must tune in with openness to the challenges posed by the unfolding discoveries in the other disciplines that grapple with the arena of human sexuality.
I will suggest ways in which research on sexual desire and gender identity may be assimilated into psychoanalytic thinking and give some examples of its use in analytic practice.