慢性乙型肝炎T细胞功能与HBV前C区变异的研究

通过研究慢性HBV感染者前C区变异及T细胞免疫功能与疾病的相关性,评估前C（preC）区变异及T细胞免疫功能对于慢性乙型肝炎（chronichepatitisB,CHB）预后的影响。分别采用实时荧光法、突变特异PCRmsPCR法及微粒酶免疫分析法对150例HBV-DNA阳性的CHB及50例健康体检者进行血清HBV-DN...     

儿童慢性乙型肝炎的抗病毒治疗

儿童慢性乙型肝炎的治疗比较复杂,应正确选择抗病毒治疗的时机,合理应用有限的治疗药物。处于免疫耐受期的患儿不应治疗,处于免疫清除期或肝脏组织学提示有明显炎症的应进行治疗。干扰素是治疗的一线药物,核苷（酸）类似物是二线用药。     

Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways

Evidence indicates that systemic administration of lipopolysaccharide (LPS) induces brain inflammation, ultimately resulting in cognitive deficits. Ursolic acid (UA), a plant-derived pentacyclic triterpenoid, is well known to possess multiple biological functions, including antioxidant, anti-tumor and anti-inflammatory activities. In the present study, we assessed the protective effect of UA against the LPS-induced cognitive deficits in mice. We found that UA significantly improved cognitive deficits of LPS-treated mice in open field, step-through passive avoidance and Morris water maze tasks. One potential mechanism of this action was attributed to the decreased production of pro-inflammatory markers including COX-2, iNOS, TNF-α, IL-1β, IL-2 and IL-6 in LPS-treated mouse brain. Mechanistically, UA markedly inhibited LPS-induced IκBα phosphorylation and degradation, NF-κB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt. Taken together, these results suggest that UA may be useful for mitigating inflammation-associated brain disorders by inhibiting pro-inflammatory factors production, at least in part, through blocking the p38/NF-κB signaling pathways.     

Review of Living Walden Two: B. F. Skinner's Behaviorist Utopia and Experimental Communities

Kuhlmann''s Living Walden Two (2005) offers a social history of the actual experimental communities that were inspired by Skinner''s (1948) utopian novel. In the course of her examination, the author presents a reasonably accurate overview of the key cultural design elements described in the novel, of behavioral philosophy applied to cultural design, and of the academic reaction to the behavioral philosophy embodied in the fictional community. She is critical of several key behavioral tenets, but generally remains analytical rather than emotional. Kuhlmann concludes that contextual and individual factors undermined the capacity of most of the experimental communities inspired by Walden Two to sustain themselves.     

On the origin and preservation of cumulative record in its struggle for life as a favored term

This paper offers a case study of the origins, emergence, and evolution of the term cumulative record as the name for the means by which B. F. Skinner brought his behavior under the control of his subject matter. Our methods included on-line searches, reviews of Skinner's publications, and journal codings and counts. The results reveal that the term is not originally attributable to Skinner, but emerged earlier in ordinary language and in another discipline--education. It was not even original to Skinner in print in his own science. Still, the term was once original to him, which we address with additional analyses of his having originated and advanced it. We conclude with a discussion the constraints of our methods, suggestions for future research, and the variable appreciation of technology and terminology in science studies.     

Pavlov And Skinner: Two Lives In Science (An Introduction To B. F. Skinner's "Some Responses To The Stimulus 'Pavlov' ")

The sesquicentennial of Ivan Petrovich Pavlov's birth in September 1999 is being celebrated in Russia by a special issue of the Russian Journal of Physiology (the former I. M. Sechenov Physiological Journal, founded by Pavlov in 1917). The following article and the address by Skinner that it introduces are scheduled to appear in Russian translation in that special issue. Skinner's “Some Responses to the Stimulus ‘Pavlov’” was his presidential address to the Pavlovian Society of North America in 1966. The following article provides the context for Skinner's address by describing some ways in which Pavlov's research influenced Skinner's contributions.     

Operants Were Never "Emitted," Feeling Is Doing, And Learning Takes Only One Trial: A Review Of B. F. Skinner's Recent Issues In The Analysis Of Behavior

This final collection of Skinner's papers was intended for the professional, although other readers will find much of interest. The first five chapters are devoted to what Skinner called “theoretical issues” and include clear presentations of his positions on “feelings” and on the “self” as an apparent agent of volition. Skinner skillfully discusses thinking, the origins of cognitive-mediational theories, and a favorite topic: the similarity of processes occurring in the histories of species and of individuals. The next four chapters cover what he called “professional issues,” including the often-misunderstood philosophy known as radical behaviorism as well as the operant aspects of behavior therapy and attempts to influence educational practices. He seemed disappointed in the lack of acceptance of programmed learning methods and pessimistic about the possibility of improving education practices. This pessimism was evident in the final section, “personal issues,” in which he expressed doubt that the powerful and self-serving forces of government, business, and religion will ever permit the changes that could be wrought by the application of behavior analysis to the great problems of society. Two other chapters in the last section will be useful to historians who are curious about the influence of logical positivism on Skinner's thinking (apparently there was not much influence) and to sophisticated readers who are interested in Skinner's retrospective consideration of his work.     

Intrusions and perseverations

Twenty-two subjects with presumed senile dementia of the Alzheimer's type (SDAT), twenty-two with dementia other than SDAT, twenty with aphasia, and seventeen healthy controls over 50 years of age were examined for intrusions and perseverations. Perseverations were defined as the immediate inappropriate repetition of a prior response whereas intrusions were defined as the inappropriate repetition of prior responses after intervening stimuli. Intrusions and perseverations occurred in demented and aphasic subjects, but were rare in controls. Intrusions occurred most often in SDAT or Wernicke aphasia, but also in dementia other than SDAT. Intrusions were not correlated with dementia severity. Intrusions are a useful sign of dementia, but they cannot be considered pathognomonic of SDAT. They appear to arise when subjects are unable to access correct responses from long-term memory and instead substitute erroneous responses selected from short-term memory. Perseverations were most common in the Wernicke aphasics and subjects with dementia due to communicating hydrocephalus. Although frontal lobe dysfunction is prominent in communicating hydrocephalus, it is absent in cases of Wernicke aphasia. Thus, we have confirmed prior suggestions that perseveration can occur in the absence of frontal lobe injury. Failure to self-monitor speech as well as an inability to change mental set probably plays an important role in the genesis of perseverations. There was no statistically significant correlation between dementia severity and number of perseverations. Low correlations were found between intrusions and perseverations suggesting that these seemingly similar behaviors are distinct and are probably produced by separate neuropsychological mechanisms.     

Residual ability to use grapheme-phoneme conversion rules in phonological dyslexia

A case of acquired phonological dyslexia is described (P.M.). The patient was encouraged to read nonwords by analogy with real words, i.e., by changing phonemes in real words to produce pronounceable nonwords. P.M. was able to perform this task suggesting that he retained some ability to use grapheme-phoneme conversion rules. On the basis of P.M.'s performance an additional connection in Morton's logogen model is postulated.     

The logical and empirical bases of conservation judgements

It is argued that conservation judgements are based on a particular combination of logical necessity and empirical belief. The empirical belief is that a given transformation will not alter a particular quantity (Elkind's conservation of identity). The logical aspect is a transitive deductive argument containing an initial equivalence of two quantities and the conservation of identity belief as premises which lead to the conclusion of maintained equivalence (Elkind's conservation of equivalence). In two experiments, it is shown that conservation of identity beliefs can be manipulated in subjects who have long since developed the capacity for transitive deductive inference. Untrained 10 year olds were unaware of how sublimation acts to alter certain quantities over particular transformations of shape. And untrained adults incorrectly believed that both the area and perimeter of a closed figure would be conserved over transformations which elongated the figure. Both groups of subjects could be trained in the correct conservation of identity beliefs and this affected their conservation of equivalence judgements in predicted ways. It is suggested that the locical aspect of conservation is developmentally stable and that the empirical aspect varies widely across problems and individuals because of its dependence on relevant experience.