乙肝抗病毒治疗存在的问题及其对策

对乙肝的治疗,抗病毒是核心和关键,但抗病毒治疗自身存在着诸多问题:费用高、疗程长、疗效有限、治疗时机和条件难以掌控;药物有潜在或者明确的不良反应;医患认知不足;疗效评价极端化;治疗中不可预测因素的干扰等。通过细致的分析,探讨了乙肝治疗中的难点,并针对这些问题和难点就未来乙肝的治疗提出了一些有益的建议。     

The ultimate challenge: prove B. F. Skinner wrong

For much of his career, B. F. Skinner displayed the optimism that is often attributed to behaviorists. With time, however, he became less and less sanguine about the power of behavior science to solve the major problems facing humanity. Near the end of his life he concluded that a fair consideration of principles revealed by the scientific analysis of behavior leads to pessimism about our species. In this article I discuss the case for Skinner's pessimism and suggest that the ultimate challenge for behavior analysts today is to prove Skinner wrong.     

Anomalous brain dominance and the immune system: Do left-handers have specific immunological patterns?

Geschwind and Behan (1982) and Geschwind and Galaburda (1985a, 1985b, 1985c) suggested a correlation between brain laterality and immune disorders. To test whether this hypothesis holds true not only for the frequency of immune diseases and circulating autoantibodies, but extends also to cellular immunity, we examined the association between handedness and markers of cellular immunity. Twenty-seven left-handed and 37 right-handed subjects were serologically screened for cellular parameters and 22 left-handed subjects were typed for human leukocyte antigen (HLA). When compared to the right-handers, the left-handed group showed a significant decrease in the inflammatory cell types CD3(+) T cells (total T cells), CD4(+) T cells (T-helper cells), and HLA-Dr (MHC-II, antigen-presenting cells) as well as in the CD19(+) cells (B cells) and CD16/CD57(+) cells (natural killer cells). We assume a relationship exists between cerebral hemispheric specialisation and the immune system not only for humoral but also for cellular immunity, and we discuss the role of the major histocompatibility complex in neurological and immunological development.     

Parental stress, coping styles, and social supports in chinese families with hepatitis-b-carrying children

The purpose of the study was to examine the hypothesis that parents’ psychological well-being can be affected by a child’s illness and their social situations. In this study, we discuss the roles of coping, social support and situational context related to stress. These factors cannot only affect stress levels but can also influence whether the individual adopts a certain type of coping style for stressful events. Parental stress, coping styles and social support were compared between groups of parents of Hepatitis B virus (HBV) carrier children or healthy children. Results showed that parents of affected children were significantly more stressed and psychologically at risk, and tended to mobilize personal resources and to rely more on themselves to solve stressful life events. They also sought help from social resources more often than did parents of healthy children. Parents of healthy children had a higher number of close friends and relatives available to them. Ninety Chinese parents and their HBV or healthy children participated in this study. These families were all living in the city of Guangzhou, China.     

Distinguishing between social reinforcement and social elicitation

The theoretical, procedural, analytic, and interpretive components of Poulson's (1983, Journal of Experimental Child Psychology, 36, 471–489) study were considered in an effort to clarify the distinction between social reinforcement and social elicitation. Contrary to Poulson's contention, DRO was not, and cannot by definition be, a control for reinforcement. More importantly, the speciestypical, social nature of the infant probably reflects the collaborative influence of elicitation and reinforcement. By carefully unravelling these two interacting processes, future conditioning studies might specially enhance our knowledge of early social development.     

A feature analysis of stuttered phonemes

Stuttered and nonstuttered phonemes of 20 adult males were analyzed for distinctive feature patterns using the Chomsky-Halle system. The features (+ consonantal), (- voice), (+ continuant), and (- strident) occured significantly more often in stuttering than in nonstuttering instances. Results suggest that adult stuttering is most likely to occur when the primary sites of tension and discoordination are lingual and laryngeal and when the speaker must shift from (- voice) to (+ voice).     

Stuttering onset after laryngectomy

Two cases of onset of stuttering subsequent to laryngectomy are reported. These patients demonstrate that the existence of a larynx is not necessary for the generation of stuttering. The findings support the hypothesis that neuromotor control of sound source (laryngeal or alaryngeal) plays a critical role in the generation of stuttering-type dysfluencies and, perhaps, even in the onset of stuttering. They also suggest that dramatic alteration in sound source has the potential for dramatically altering fluency.     

Contiguity and contingency in instrumental conditioning

There have been several attempts to construct molar theories of conditioning on the empirical basis that response-reinforcement contingency is important in determining conditioning. Such theories claim to explain behavior in terms of molar level processes which transcend the molecular level and, therefore, are not reducible to molecular processes or their interaction. These molar theories are critically examined and found to be seriously flawed because they fail to account for the effects of delaying reinforcement (degree of contiguity). Observed molar level relations, such as the matching law, do not require a molar theory, but may be more usefully considered as a product of molecular processes.     

Immunization of opioid analgesia: Effects of prior escapable shock on subsequent shock-induced and morphine-induced antinociception

In Experiment 1, it was shown that experience with escapable foot shock 4 hr prior to a session of 80 inescapable tail shocks prevented the occurrence of an analgesic response normally observed immediately following the tail shock. It has been suggested by J. W. Grau, R. L. Hyson, S. F. Maier, J. Madden, and J. D. Barchas (Science, 1981, 213, 1409–1411) that the analgesia that occurs following this number of inescapable tail shocks is mediated by endogenous opioid systems. To further explore the influence of escapable shock on opiate-mediated analgesia, Experiment 2 examined the effects of prior escapable shock on the long-term analgesia reaction that occurs upon brief exposure to shock 20 hr after morphine administration. Rats were given escapable shock, inescapable shock, or no shock 4 hr prior to a morphine injection. Twenty hours following the injection, all subjects received 5 brief foot shocks and were then immediately given tail-flick analgesia tests. Subjects which received inescapable shock or no shock prior to the morphine injection displayed a significant analgesic response. However, subjects which received escapable shock prior to morphine were not analgesic following brief exposure to shock. Thus, escapable shock seems to directly influence the activation of opioid analgesia systems.