Association of polymorphisms in BDNF, MTHFR, and genes involved in the dopaminergic pathway with memory in a healthy Chinese population

The contribution of genetic factors to the memory is widely acknowledged. Research suggests that these factors include genes involved in the dopaminergic pathway, as well as the genes for brain-derived neurotrophic factor (BDNF) and methylenetetrahydrofolate reductase (MTHFR). The activity of the products of these genes is affected by single nucleotide polymorphisms (SNPs) within the genes. This study investigates the association between memory and SNPs in genes involved in the dopaminergic pathway, as well as in the BDNF and MTHFR genes, in a sample of healthy individuals. The sample includes 134 Taiwanese undergraduate volunteers of similar cognitive ability. The Chinese versions of the Wechsler Memory Scale (WMS-III) and Wechsler Adult Intelligence Scale (WAIS-III) were employed. Our findings indicate that the BDNF Met66Val polymorphism and dopamine receptor D3 (DRD3) Ser9Gly polymorphism are associated significantly with long-term auditory memory. Further analysis detects no significant associations in the other polymorphisms and indices. Future replicated studies with larger sample sizes, and studies that consider different ethnic groups, are encouraged.     

Instruction Modes for Motor Control Skills Acquisition: A Randomized Controlled Trial

Abstract

The objective was to compare two different instruction modes used to teach patients with nonspecific chronic low back pain (CLBP) to perform a lumbar motor control task. The three intervention instruction modes used were: common verbal explanation of a motor task based on a motor control therapeutic exercise (MCTE-control group), MTCE instructed using motor imagery (MI) and MCTE instructed using tactile feedback (TF). The main outcome measure was lumbar motor control of the neutral position test. Forty-eight patients with CLBP were randomly allocated into three groups of 16 patients per group. The MI strategy was the most effective mode for developing the motor control task in an accurate and controlled manner, obtaining better outcomes than TF or verbal instruction.     

Effects of Different Ratios of Physical and Mental Practice on Postural Control Improvement

Abstract

Mental practice (MP) is a reliable alternative or complement to physical practice (PP) for the training of postural control. We address how MP should ideally be combined with PP. Participants were assigned to four experimental groups where MP/PP ratios during training varied from 0 to 100%. Performance improved only for demanding postural adjustments, regardless of MP/PP ratio, and learning was partially consolidated after a night of sleep. Findings reinforce the relevance of MP for the training of weight shifting and further suggest that MP alone can be as efficient as PP for the learning of certain complex postural adjustments.     

Eye-movements support chronometric imagery performance even when the task is occluded

ABSTRACT

Mental chronometry has often been used to provide a temporal comparison between executed and imagined movements, with smaller discrepancies indicating more accurate image production and better imagery performance. In this study, we examined the importance of retinal and extra-retinal information in the performance of simple, sequential movements. After physical practice of four activities of daily living (Southampton Hand Assessment Procedure), nineteen participants imagined completing the same tasks with: 1) free eye-movements and visible objects, 2) free eye-movements and no visibility of the objects, and 3) constrained eye-movements and visible objects. Results suggested imagery performance was slower/less accurate compared to physical execution when the eyes were constrained. Conversely, chronometric imagery performance was unaffected with free eye movements, even when task-specific visual information was occluded. This study highlights the crucial role that eye-movements play in the regulation of the temporal aspects of imagery even when retinal information is absent, suggesting that temporal sequencing of imagined actions is largely dependent on extra-retinal information sources.     

The power of the written word: Comparing word meaning inferencing from auditory and written modalities throughout grade school

Previous research indicates that word learning from auditory contexts may be more effective than written context at least through fourth grade. However, no study has examined contextual differences in word learning in older school-aged children when reading abilities are more developed. Here we examined developmental differences in children’s ability to deduce the meanings of unknown words from the surrounding linguistic context in the auditory and written modalities and sought to identify the most important predictors of success in each modality. A total of 89 children aged 8–15 years were randomly assigned to either read or listen to a narrative that included eight novel words, with five exposures to each novel word. They then completed three posttests to assess word meaning inferencing. Children across all ages performed better in the written modality. Vocabulary was the only significant predictor of success on the word inferencing task. Results indicate support for written stimuli as the most effective modality for novel word meaning deduction. Our findings suggest that the presence of orthographic information facilitates novel word learning even for early, less proficient readers.     

A Note on State Individual Differences in Accuracy of Response Imagery: Aftereffects and Reminiscence

In two sessions, separated by 7 days, subjects imagined themselves performing a tracking task under a massed practice schedule. After conditions of interpolated rest and no-rest, which were counterbalanced across sessions, subjects actually performed the tracking task. During imagery practice, subjects verbally reported the temporal component of the task. The temporal accuracy of verbal reports varied widely across subjects, but not within subjects. Furthermore, a performance gain was demonstrated as a function of interpolated rest versus no-rest (reminiscence effect). Finally, the accuracy of verbal reports predicted imagery aftereffects, but not reminiscence effects.     

The predictive moment: reverie,connection and predictive processing

ABSTRACT

According to the theory of predictive processing, understanding in the present involves non-consciously representing the immediate future, based on probabilistic inference shaped by learning from the past. This paper suggests links between this neuroscientific theory and the psychoanalytic concept of reverie – an empathic, containing attentional state – and considers implications for the ways therapists intuit implicit material in their clients. Using findings from a study about therapists’ experiences of this state, we propose that reverie can offer practitioners from diverse theoretical backgrounds a means to enter the predictive moment deeply, making use of its subtle contents to connect with clients.     

Sleep dependent consolidation of gross motor sequence learning with motor imagery

Acquisition of gross motor sequence learning with physical and mental training elicits gains in performance. However, the effects of sleep or daytime consolidation after both types of practice remain unclear, especially the effects upon the goal- and movement-based components of a gross motor sequential task. The main purpose of this study was to test the effect of physical practice (PP) and motor imagery practice (MIP) on the acquisition and consolidation processes of gross motor sequence learning.Seventy-six participants were tested before and after PP or MIP on a whole-body sequential paradigm, following either a night of sleep (PP_sleep and MIP_sleep groups) or an equivalent daytime period (PP_day and MIP_day groups). Control groups without training were tested following similar timespans (CTRL_sleep and CTRL_day groups). The number of sequential movements and the centre of mass displacement – corresponding to goal and movement-based components, respectively – were assessed.Results showed that relative to the CTRL groups, the PP and MIP groups improved performance during acquisition. Importantly, only the MIP_sleep group further improved performance after a night of sleep; participants of other groups stabilised their performance after consolidation. Additionally, the number of sequential movements and the centre of mass displacement evolved conjointly without being influenced by the type of training or the nature of the consolidation.To conclude, these results confirm that sleep contributes to the consolidation of gross motor sequence learning acquired with MIP but not PP. The relationship between the goal- and movement-based components of a gross motor sequential task is discussed.     

Mental imagery and fiction

Fictions evoke imagery, and their value consists partly in that achievement. This paper offers analysis of this neglected topic. Section 2 identifies relevant philosophical background. Section 3 offers a working definition of imagery. Section 4 identifies empirical work on visual imagery. Sections 5 and 6 criticize imagery essentialism, through the lens of genuine fictional narratives. This outcome, though, is not wholly critical. The expressed spirit of imagery essentialism is to encourage philosophers to ‘put the image back into the imagination’. The weakened conclusion is that while an image is not essential to imagining, it should be returned to our theories of imagination.