Young adults with severe congenital hypothyroidism: cognitive event related potentials (ERPs) and the significance of an early start of thyroxine treatment

Congenital hypothyroidism (CH) has devastating effects upon brain development if left untreated. Despite early start of thyroxine treatment, patients still show subtle cognitive deficits compared to controls. We aimed to study auditory event related potentials (ERPs) in young CH adults (N = 12) to verify previous reports of normal attention functions measured by P3 in CH children. We also include ERP components (P1, N1, P2) allowing assessment of a wider range of auditory processing functions. No significant change in P3 latency or amplitude was found in the CH group, but a more subtle change in amplitude topography. A later start of thyroxine treatment was related to increased P3 latency and reduced amplitude. Group differences were found in early ERP components tapping sensory processing, sensory gating and selective attention. The results suggest persisting abnormalities in auditory processing and selective attention that may have influenced cognitive development.     

视觉空间注意的事件相关电位研究

视觉空间注意是心理学多年来一直探讨的问题,也是近来多学科共同关注的领域。在脑机制研究中,事件相关电位(ERP)的研究方法具有高时间分辨率的特点,近年来高密度记录技术的发展,也提高了ERP在功能定位方面的作用,因此其应用日益广泛。该文概述了近年来有关ERP在视觉空间注意研究中的实验方法、结果和初步结论,并就今后研究方向提出了几点看法。     

位置提示下视觉注意范围的调控机制

研究视觉空间注意中不同注意范围引起脑内加工时程的动态变化。使用固定位置的、三种不同直径的线圈作为注意范围的位置性提示,祛除空间定位因素的影响,记录反应时和事件相关电位（ERP）数据。结果显示：在同等注意范围时,随着刺激位置远离视野中心,反应时延长,靶刺激诱发的P1、N1不受刺激位置的影响,而其前部N2的波幅明显受到刺激位置的影响;在靶刺激位置相同时,随着注意范围的扩大,反应时缩短,靶刺激诱发的P1、N1不受提示范围大小的影响,而其前部P2的波幅明显受到注意范围的影响。结果说明：①视觉注意范围信息加工与靶刺激诱发的P2成分相关;②视觉注意诱发的P1、N1成分,主要与注意方位相关,而与注意范围大小无关;③注意范围变化引起注意集中度的调节是在一定范围内进行的。     

固定位置区域提示下视觉注意范围等级的ERP研究

研究视觉空间注意中注意范围的脑内时程的动态变化。被试为 14名青年人 ,使用固定位置的、3种不同直径的线圈作为注意范围的区域性提示 ,祛除空间定位因素的影响 ,记录反应时和事件相关电位 (ERP)数据。结果显示 :提示范围由小到中等时 ,反应时延长 ,而由中等到大范围时 ,反应时缩短 ;提示物和靶刺激诱发ERP的早成分 (N1、P1)不受提示范围大小的调节 ,而其P2、N2的波幅与潜伏期均明显受到提示范围大小的影响。这些结果说明 :①视觉注意诱发的P1、N1成分 ,主要与空间定位信息的加工相关 ;②提示物诱发的P2、N2成分与注意范围相关 ;③在视觉信息加工过程中 ,空间位置的信息要早于其它信息被加工 ,支持视觉信息串行加工观点     

跨通路识别汉字形音的偏差相关成分研究

采用提高非注意纯度的“跨通路延迟反应”实验范式,研究汉字形音识别的跨通路注意事件相关电位（ＥＲＰ）,以偏差刺激ＥＲＰ减去标准刺激ＥＲＰ的早期偏差相关负波（ＤＲＮ１）为主要分析对象。以１５名正常青年为被试。结果发现：无论注意与否及何种刺激,听觉Ｎ１最大峰均位于额中央部,而视觉Ｎ１最大峰位于两侧枕部与颠后部,具有明显的通路差异性。在本实验条件下,听觉与视觉通路的ＤＲＮ１与失匹配负波（ＭＭＮ）在许多性质上相似,反映着对汉字形音识别的自动加工。根据波幅及其头皮分布特点,注意条件下的Ｎ３５０很可能是Ｎ２００与Ｎ４００的重叠,并主要表现出Ｎ４００的特点;而非注意条件下的Ｎ３５０则可能是Ｎ２００。Ｎ３５０的属性因条件而异,表明ＥＲＰ成分反映的大脑加工机制具有可塑性。     

Effects of primary task predictability and secondary task modality on lane maintenance

The objective of this work was to investigate the effects of auditory and visuo-spatial secondary tasks on variability in lane position in predictable and unpredictable driving conditions. Sixty-six participants drove a simulated vehicle. Predictability was manipulated by adding wind gusts, and the secondary task load by either an auditory task (Experiment 1) or a visuo-spatial task (Experiment 2). Results demonstrated that in the predictable driving condition, lane position variability decreased when auditory secondary task load was given, but it was not affected by visuo-spatial secondary task load. In the unpredictable driving condition; however, while the auditory secondary task load did not affect lane position variability, visuo-spatial secondary task load increased it. The data suggests that the effects of cognitive load on lane maintenance may depend on the type of the secondary task beside predictability of primary task.     

Sense of agency over thought: external misattribution of thought in a memory task and proneness to auditory hallucination

Previous studies have suggested that auditory hallucination is closely related to thought insertion. In this study, we investigated the relationship between the external misattribution of thought and auditory hallucination-like experiences. We used the AHES-17, which measures auditory hallucination-like experiences in normal, healthy people, and the Deese–Roediger–McDermott paradigm, in which false alarms of critical lure are regarded as spontaneous external misattribution of thought. We found that critical lures elicited increased the number of false alarms as AHES-17 scores increased and that scores of AHES-17 predicted the rate of false memory of critical lures. Furthermore, we revealed that the relationship between AHES-17 scores and the rates of false alarms to critical lures was strictly linear. Therefore, it might be said that individual differences in auditory hallucination-like experiences are highly related to the external misattribution of thought. We discussed these results from the perspective of the sense of agency over thought.     

Anticipatory attention during the sleep onset period

To examine whether anticipatory attention or expectancy is a cognitive process that is automatic or requires conscious control, we employed a paired-stimulus event-related potential (ERP) paradigm during the transition to sleep. The slow negative ERP wave observed between two successive stimuli, the Contingent Negative Variation (CNV), reflects attention and expectancy to the second stimulus. Thirteen good sleepers were instructed to respond to the second stimulus in a pair during waking sessions. In a non-response paradigm modified for sleep, participants then fell asleep while tones played. As expected, N1 decreased and P2 increased in amplitude systematically with the loss of consciousness at sleep onset; the CNV was increasingly more positive. Sleep onset latency was correlated with the amplitude of the CNV. The systematic attenuation of the CNV waveform at sleep onset and its absence in sleep indicates that anticipatory attention requires endogenous conscious control.     

The varieties of inner speech: links between quality of inner speech and psychopathological variables in a sample of young adults

A resurgence of interest in inner speech as a core feature of human experience has not yet coincided with methodological progress in the empirical study of the phenomenon. The present article reports the development and psychometric validation of a novel instrument, the Varieties of Inner Speech Questionnaire (VISQ), designed to assess the phenomenological properties of inner speech along dimensions of dialogicality, condensed/expanded quality, evaluative/motivational nature, and the extent to which inner speech incorporates other people’s voices. In response to findings that some forms of psychopathology may relate to inner speech, anxiety, depression, and proneness to auditory and visual hallucinations were also assessed. Anxiety, but not depression, was found to be uniquely positively related to both evaluative/motivational inner speech and the presence of other voices in inner speech. Only dialogic inner speech predicted auditory hallucination-proneness, with no inner speech variables predicting levels of visual hallucinations/disturbances. Directions for future research are discussed.     

No evidence for a cue mismatch in negative priming

An experiment is reported in which the cue mismatch hypothesis of negative priming, an important novel variant of the mismatching hypothesis, was tested. A cue mismatch and a no mismatch condition were contrasted in a visual discrimination task. In the prime display of cue mismatch ignored-repetition trials, the colour of the prime distractor was different from the colour of the cue indicating the selection feature (coloured square). In probe displays, cue and repeated stimulus had the same colour. In the no mismatch condition, the visual cue was neutral in terms of colour (always black), so that there was always no cue mismatch between prime and probe displays. Contrary to the prediction of the cue mismatch hypothesis, the negative priming effect was not larger in the cue mismatch than in the no mismatch condition. The cue mismatch hypothesis must therefore be rejected. In contrast, the episodic retrieval account is consistent with the results.