Regional cerebral blood flow measurements by 133Xe-inhalation: Methodology and applications in neuropsychology and psychiatry

This review describes methodological improvements of the ¹³³Xe-inhalation technique for measurement of regional cerebral blood flow (rCBF) comprising correction routines both for scattered radiation from air passages and for remaining activity from previous measurements, as well as a new index of curve fit exactness. Measurements in normals are described showing new characteristics of the resting flow pattern and localized flow changes during activation with a variety of mental tasks. Our clinical applications in psychiatry are reviewed demonstrating the ability of the rCBF technique for differential diagnosis of dementia, for the evaluation of treatment by drugs, ECT, or psychosurgery, as well as for following, cases of toxic influence. The paper finally discusses the potentials as well as the limitations and artifacts of the technique.     

Effects of induced elation-depression on the accessibility of memories of happy and unhappy experiences

Elated and depressed moods were induced in student volunteers on separate occasions. On each occasion they retrieved past real-life experiences associated to stimulus words presented. Subjects subsequently rated the experiences for happiness-unhappiness and pleasantness-unpleasantness on a third occasion in a neutral mood state. Extremely unhappy memories were significantly more likely to be retrieved in the depressed mood than in the elated mood. Extremely happy memories were significantly more likely to be retrieved in the elated mood than in the depressed mood. Measures of latency of retrieval showed a significant interaction between mood state and type of memory. The results confirm the generality of previous findings in suggesting an effect of mood state on the accessibility of different types of cognition. The results are considered in relation to mood as a context in contextual-specific encoding and retrieval, and in relation to models and treatment of clinical conditions.     

Cognitive restructuring treatment: A controlled trial with anxious patients

Cognitive restructuring, modified systematic desensitization and a combined treatment (cognitive behaviour modification) were compared with a no-treatment control group, using a simple randomized design. Twenty seven general anxiety out-patients selected from the hospital waiting list were used as subjects. Assessments were made at the beginning and end of treatment, and at follow-up 1 month later. The assessments included two subjective anxiety measures, the Zung self-rating anxiety scale and fear thermometer scores, a behavioural anxiety measure, a measure of cognitive anxiety as estimated by a diary recording of thinking time, fear survey schedule scores and I/E scores.Cognitive behaviour modification was found to be a superior form of treatment, relative to the no-treatment control and the other active treatment groups as assessed by FSS intensity score. The cognitive behaviour modification group showed greater improvement than the cognitive restructuring group on the diary anxiety scores. The results also demonstrated a relationship between outcome and initial severity of condition. The higher the subjects' initial scores on neurotic symptoms and subjective anxiety level, the greater the degree of positive change after treatment. Moreover, subjects with high levels of internal control prior to treatment responded most to therapy.     

Lexical knowledge in anterior and posterior aphasics

A semantic categorization task was used to assess the structure of lexical knowledge in anterior and posterior aphasics. In general responses were faster for typical category members than for atypical ones and slower for semantically related nonmembers than for unrelated ones. Both groups performed at a high level of accuracy when classifying typical category members and semantically unrelated nonmembers. Their performance diverged at the category boundary. Anterior aphasics maintained relatively high levels of accuracy when classifying atypical category members and semantically related nonmembers while posterior aphasics did not. These results point to differences in the status of lexical knowledge for anterior and posterior aphasics.     

Career development and career choice in pioneer and traditional women

Two groups of college seniors were compared in an attempt to elucidate those factors affecting feminine career choice and career development. The sample consisted of 106 female Caucasian students enrolled at a large Southwestern university. Sixty-three of the subjects were majoring in traditional female fields, while the remaining 43 were majoring in male-dominated areas. Five instruments were administered to the subjects. Seven factors were found to distinguish significantly between the two groups of women. Of the seven, three factors pertained to feminine role perception. The remaining four were concerned with sex-role stereotyping and various aspects of family background.     

Patterns of spontaneous recovery in aphasic groups: A study of adult stroke patients

The recovery of 31 aphasic stroke patients in the first three months postonset was investigated. Improvements on eight comprehension, repetition, and expression tasks were documented for four groups. These groups, retrospectively defined on the basis of initial scores on a fluency and a comprehension task, were: Low Fluency/Low Comprehension (LFLC), Low Fluency/High Comprehension (LFHC), High Fluency/Low Comprehension (HFLC), and High Fluency/High Comprehension (HFHC). Examination of each group's recovery revealed (1) equal improvement on nearly all language tasks for the two High Comprehension groups and (2) a more selective improvement largely in comprehension and imitation tasks for the two Low Comprehension groups. Implications of this selective improvement in initially low comprehending aphasics are discussed.     

Regional blood flow changes in the left cerebral hemisphere during word pair learning and recall

Regional cerebral blood flow measurements were made in the left hemisphere of 11 young healthy volunteers during learning and during recalling of word pair associates. Compared to the resting baseline, both tasks caused significant increases of average hemispheric flow, indicating an elevated neuronal activity level. Regionally both tasks were accompanied by considerable activation of parietal and occipital regions. The main difference between learning and recalling was that only the former task activated the prefrontal regions.     

Speech abnormalities in seizures: a comparison of absence and partial complex seizures

In order to determine whether speech changes are useful in differentiating seizure types, a study was done in which speech abnormalities during two distinct seizure types, partial complex and absence seizures, were compared. Speech changes noted during prolonged electroencephalographic and video monitoring were compared in 16 patients with 47 partial complex seizures and 19 patients with 95 absence seizures. Speech changes were common during both seizure types. Although some significant differences in speech patterns were noted in the two seizure types, the degree of overlap was such to preclude using speech changes alone as the sole clinical criteria in differentiating the seizures.