Basal ganglia, dopamine and temporal processing: performance on three timing tasks on and off medication in Parkinson's disease

A pervasive hypothesis in the timing literature is that temporal processing in the milliseconds and seconds range engages the basal ganglia and is modulated by dopamine. This hypothesis was investigated by testing 12 patients with Parkinson's disease (PD), both 'on' and 'off' dopaminergic medication, and 20 healthy controls on three timing tasks. In a seconds range (30-120 s) time production task, patients tested 'on' medication showed a significantly different accuracy profile compared to controls and when tested 'off' medication. However, no group or on vs off medication differences in accuracy were found on a time reproduction task and a warned reaction time task requiring temporal processing within the 250-2000 ms range. Variability was measured using the coefficient of variation, with the performance of the patient group on the time reproduction task violating the scalar property, suggesting atypical temporal processing mechanisms. The data suggest that the integrity of the basal ganglia is necessary for 'typical' time production in the seconds range as well as for time reproduction at shorter intervals. Exploratory factor analysis suggested that the time production task uses neural mechanisms distinct from those used in the other two timing tasks. The dissociation of the effects of dopaminergic medication and nature of task on performance in PD raises interesting questions about the pharmacological mediation and task-specificity of deficits in temporal processing.     

Stimulus timing by people with Parkinson's disease

Previous literature suggests that Parkinson’s disease is marked by deficits in timed behaviour. However, the majority of studies of central timing mechanisms in patients with Parkinson’s disease have used timing tasks with a motor component. Since the motor abnormalities are a defining feature of the condition, the status of timing in Parkinson’s disease remains uncertain. Data are reported from patients with mild to moderate Parkinson’s disease (both on and off medication) and age- and IQ-matched controls on a range of stimulus timing tasks without counting. Tasks used were temporal generalization, bisection, threshold determination, verbal estimation, and a memory for duration task. Performance of patients was generally “normal” on all tasks, but significant differences from performance of controls were found on the memory for duration task. Among the “normal” effects noted were arithmetic mean bisection, asymmetric temporal generalization gradients, and subjective shortening on the memory for duration task. The results suggest (a) that some previous reports of timing “deficits” in Parkinson’s patients were possibly due to the use of tasks requiring a timed manual response and (b) small differences between patients and controls may be found on tasks where two stimuli are presented on each trial, whether patients are on medication or off it.     

Cultural variation in the motivational standards of self-enhancement and self-criticism among bicultural Asian American and Anglo American students

Recent work on biculturalism has made theoretical and methodological inroads into our understanding of the relation of cultural processes with psychological functioning. Through the use of cultural priming methodologies, investigators have demonstrated that biculturals, or individuals who have experienced and identify with more than one culture, can switch between various "cultural frames of reference" in response to corresponding social cues (Hong, Morris, Chiu, & Benet-Martinez, 2000). Drawing on this work on the cognitive implications of biculturalism, the purpose of the present study was to examine the assumption that independent and interdependent self-construals are associated with the motivational standards of self-enhancement and self-criticism, respectively. More specifically, the effects of differential primes of self on ratings of self-enhancement were investigated in a sample of bicultural Asian American (N = 42) and Anglo American (N = 60) college students; overall, more similarities than differences were noted between the two groups. It was hypothesized that Anglo American students would display marked tendencies toward self-enhancement. However, this hypothesis was not supported. Nevertheless, consistent prime effects were observed for a selected number of ratings related to academic virtues, with those who received an independent-self prime often exhibiting greater self-enhancing tendencies than those who received an interdependent-self prime. For example, participants in the independent-self condition reported on average significantly higher ratings for self-discipline and initiative, as well as the degree to which they perceived themselves to be hard working. Implications for the work on self-representations, motivation, and acculturation are discussed.     

Some effects of noncontingent positive reinforcement on multiply controlled problem behavior and compliance in a demand context

Functional analysis suggested that the problem behavior of an 8-year-old girl with autism was maintained by escape from demands and access to edible items. Noncontingent delivery of an edible item was sufficient to increase compliance and reduce the rate of problem behavior without the use of escape extinction in a demand context. Leaner and richer schedules of noncontingent reinforcement were equally effective, and there were minimal differences between noncontingent reinforcement and differential reinforcement of compliance.     

Eyberg Child Behavior Inventory (ECBI): Norwegian norms to identify conduct problems in children

This article presents the first Norwegian standardization of an assessment tool specifically designed to measure childhood conduct problems. Norwegian norms for the Eyberg Child Behavior Inventory (ECBI) based on data obtained from a random population sample (N= 4063) of children in the age range of 4 to 12 years are presented. The sample was drawn from rural and urban areas within three Norwegian town districts. Clinical and research advantages of having a properly standardized assessment tool for this specific subclass of childhood psychiatric problems in Norway are discussed.     

Is a sigh “just a sigh”? Sighs as emotional signals and responses to a difficult task

Sighing and the interpretation of sighs in everyday life seem never to have been the subject of psychological research. A questionnaire study of sighing showed that people associate sighing mainly with negative, low-intensity and deactivated emotional states. A second study investigated self/other differences in the interpretation of sighs in four hypothetical situations, revealing that sighs in other people are primarily perceived as signs of sadness, whereas own sighs are more often believed to express a state of "giving up" something or somebody. In a third experimental study participants worked on difficult (insoluble) puzzles, which generated many futile solution attempts, often accompanied by sighs. It is concluded that sighs are often unintentional expressions of an activity, plan or desire that has to be discarded, creating a pause before it can be replaced by a novel initiative.     

Nietzsche as ‘Europe’s Buddha’ and ‘Asia’s Superman’

Nietzsche represents in an interesting way the well-worn Western approach to Asian philosophical and religious thinking: initial excitement, then neglect by appropriation, and swift rejection when found to be incompatible with one’s own tradition, whose roots are inexorably traced back to the ‘ancient’ Greeks. Yet, Nietzsche’s philosophical critique and methods - such as ‘perspectivism’ - offer an instructive route through which to better understand another tradition even if the sole purpose of this exercise is to perceive one’s own limitations through the eyes of the other: a self-destruktion of sorts. To help correct this shortcoming and begin the long overdue task of even-handed dialogue - or contemporary comparative philosophy - we will be served well by looking at Nietzsche’s mistakes, which in turn informed the tragic critic of the West of the last century, Martin Heidegger. We may learn here not to cast others in one’s own troubled image; and not to reverse cultural icons: Europe’s Superman, and Asia’s Buddha.

Why Theists Cannot Accept Skeptical Theism

In recent years skeptical theism has gained currency amongst theists as a way to escape the problem of evil by invoking putatively reasonable skepticism concerning our ability to know that instances of apparently gratuitous evil are unredeemed by morally sufficient reasons known to God alone. After explicating skeptical theism through the work of Stephen Wykstra and William Alston, I present a cumulative-case argument designed to show that skeptical theism cannot be accepted by theists insofar as it crucially undermines epistemic license to the very theism it is invoked to defend. I also argue that attempts to defend a theism-friendly moderate version of skeptical theism either fail to halt the spread of damaging skepticism, or lack philosophical validity.

Epistemic luck and the generality problem

Epistemic luck has been the focus of much discussion recently. Perhaps the most general knowledge-precluding type is veritic luck, where a belief is true but might easily have been false. Veritic luck has two sources, and so eliminating it requires two distinct conditions for a theory of knowledge. I argue that, when one sets out those conditions properly, a solution to the generality problem for reliabilism emerges.