Performance of an Adapted Version of the Timed Up-and-Go Test in People with Cognitive Impairments

In clinical practice, older people with cognitive impairment may have difficulties to understand the instructions of the Timed Up-and-Go (TUGT) test and present a bad performance. The purpose of this study was to identify differences in the TUGT performance, in an adapted version, between older adults with preserved cognition (PC), mild cognitive impairment (MCI) and Alzheimer's disease (AD), and to identify the association between the adapted TUGT performance and cognition among groups. A cross-sectional study was conducted with 118 community-dwelling older adults divided in three groups: PC (n?=?40), MCI (n?=?40) and AD (n?=?38). The evaluation was composed by the adapted TUGT and cognitive assessment (Addenbrooke's Cognitive Examination and Frontal Assessment Battery). Only the cadence of TUGT presented significant difference between groups, specifically between AD versus MCI and PC groups. The main correlations were found between time of TUGT with fluency domain and global cognitive function, especially in the AD Group. The findings contribute to the understanding of how cognition interferes on functional mobility in older people with MCI and AD. The adapted TUGT is easy to perform in clinical practice and can be useful when assessing mobility in people with cognitive impairment.     

认知诊断模型Q矩阵修正：完整信息矩阵的作用

Q矩阵是CDM的核心元素之一,反映了测验的内部结构和内容设计,通常由领域专家根据经验进行主观界定,因此需要对可能存在的错误进行修正。本研究提出了一种新的Q矩阵修正方法——基于完整经验交叉相乘信息矩阵的Wald-XPD方法。采用Monte Carlo模拟检验了新方法的表现,并与同类方法进行了比较。研究表明：新开发的Wald-XPD方法在Q矩阵恢复率、保留正确标定属性的比例以及修正错误标定属性的比例这3个主要指标上均有较好的表现,且整体上优于其他方法,尤其是在修正错误标定的属性方面。通过实证数据展示了Wald-XPD方法在Q矩阵修正中的良好表现。总之,本研究为Q矩阵修正提供了有效的方法。     

Psychobiological Treatment Response to a Two-Week Posttraumatic Stress Disorder and Mild Traumatic Brain Injury Integrated Treatment Program: A Case Report

Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) demonstrate high prevalence and comorbidity among post-9/11 veterans. Veterans with this comorbidity often present with multiple co-occurring healthcare needs and increased clinical complexity. The current case report describes the clinical presentation of a veteran with mild TBI and PTSD, both before, during, and after treatment within a multidisciplinary 2-week intensive outpatient program involving prolonged exposure, evidence-based PTSD treatment, and Cognitive Symptom Management and Rehabilitation Therapy, evidence-based treatment for postconcussive symptoms. Mr. A was a 25-year-old White, transgender male who presented with a complex mental health history. At intake, presenting complaints included anxiety, panic attacks, nightmares, and depression secondary to military sexual trauma, as well as reported cognitive difficulties secondary to a concussion. He met current criteria for PTSD as well as panic disorder with agoraphobia. Head injury history consisted of a motor vehicle collision with less than 30 seconds loss of consciousness, brief posttraumatic amnesia, and alterations of consciousness. Mr. A demonstrated habituation during individual exposure sessions as assessed via skin conductance during imaginal exposures and decreased subjective ratings during in vivo exposures, as well as a decrease in trauma-potentiated startle response to trauma cues. Posttreatment data indicates significant reduction in neurobehavioral, posttraumatic stress, and depression symptoms and significant improvement in subjective cognitive functioning. The current findings support the feasibility and efficacy of short-term integrated treatment for complex clinical presentations and the need for larger scale research investigating combined PTSD and TBI intervention.     

From the Macro to the Micro: A Geographic Examination of the Community Context and Early Adolescent Problem Behaviors

This study examined how multiple dimensions and levels of the community context associated with early adolescent problem behaviors in rural communities. Four thousand, five hundred and nine eighth-grade students in 28 rural and small town school districts in two states participated in surveys regarding substance use and delinquency in 2005. Locations of alcohol retailers, tobacco retailers, youth-serving organizations, and student residences were geocoded. Associations of the number of proximal alcohol and tobacco retailers, and youth-serving organizations with an early-adolescent problem behavior index were tested in Nonlinear Mixed Models that controlled for multiple district-level and individual characteristics. Multi-level model results demonstrated that the number of alcohol and tobacco retail locations within a one-mile radius of each adolescent's home positively associated with student-reported problem behaviors above and beyond the influence of school district and individual characteristics. Results suggest that the proximal community context added significantly to the district context when understanding the occurrence of early adolescent problem behaviors. Recognizing this variability in geographically determined risk within a community will likely enhance the effectiveness of community prevention activities.     

客体-空间表象和言语认知风格模型及其测量

在言语-表象认知风格模型中, 视觉表象认知风格一直被视为单一的结构, 且在此基础上发展出的各种测量方法均存在效度上的缺陷, 导致了研究者对该认知风格模型的普遍质疑。随着对视觉认知加工研究的深入, 尤其是对视觉客体表象与视觉空间表象在功能和解剖上的双分离的理解, 为进一步区分表象型认知风格提供了理论和实证依据, 进而促进了客体-空间表象和言语(Object-Spatial Imagery and Verbal, OSIV)认知风格模型的提出, 而在此基础上开发的新测量工具(Object-Spatial Imagery and Verbal Questionnaire, OSIVQ)具有良好的信、效度, 有力地支持了OSIV认知风格模型。OSIV认知风格模型及其测量为研究人类的认知风格以及视觉认知拓展了新视野。尽管如此, 两种不同视觉表象子系统并存于个体的视觉表象系统中, 因此, 它们分离的原因、相互作用及其与视觉注意之间的关系有待进一步研究。     

建言效能感结构及其在员工建言行为发生中的作用

作为一种组织促进性行为, 员工建言在知识经济时代对组织的作用日益显著。学界从多角度探讨了建言的发生机制, 然而从认知的视角的研究则较为缺乏。本研究从社会认知理论视角, 构建了建言效能感结构(研究一), 并探索了建言效能感在建言行为发生中的作用(研究二)。研究一从长三角地区企业的26名基层员工中提取建言效能感关键事件, 编制初始问卷, 通过对188个样本的探索性因子分析及对另188个样本的验证性因子分析, 探索并验证了建言效能感的结构及其量表; 研究二通过对401份“员工－上级”配对样本的问卷研究显示, 一般自我效能感对建言行为有着正向影响, 且建言效能感在其中起着中介作用, 工作可得性缓冲调节建言效能感与建言行为之间的关系。     

What artificial grammar learning reveals about the neurobiology of syntax

In this paper we examine the neurobiological correlates of syntax, the processing of structured sequences, by comparing FMRI results on artificial and natural language syntax. We discuss these and similar findings in the context of formal language and computability theory. We used a simple right-linear unification grammar in an implicit artificial grammar learning paradigm in 32 healthy Dutch university students (natural language FMRI data were already acquired for these participants). We predicted that artificial syntax processing would engage the left inferior frontal region (BA 44/45) and that this activation would overlap with syntax-related variability observed in the natural language experiment. The main findings of this study show that the left inferior frontal region centered on BA 44/45 is active during artificial syntax processing of well-formed (grammatical) sequence independent of local subsequence familiarity. The same region is engaged to a greater extent when a syntactic violation is present and structural unification becomes difficult or impossible. The effects related to artificial syntax in the left inferior frontal region (BA 44/45) were essentially identical when we masked these with activity related to natural syntax in the same subjects. Finally, the medial temporal lobe was deactivated during this operation, consistent with the view that implicit processing does not rely on declarative memory mechanisms that engage the medial temporal lobe. In the context of recent FMRI findings, we raise the question whether Broca’s region (or subregions) is specifically related to syntactic movement operations or the processing of hierarchically nested non-adjacent dependencies in the discussion section. We conclude that this is not the case. Instead, we argue that the left inferior frontal region is a generic on-line sequence processor that unifies information from various sources in an incremental and recursive manner, independent of whether there are any processing requirements related to syntactic movement or hierarchically nested structures. In addition, we argue that the Chomsky hierarchy is not directly relevant for neurobiological systems.     

Descartes on Life and Sense

My aim…is to show that the celestial machine is likened not to a kind of divine living being but rather to a clockwork. (Kepler, 1605) I consider the human body to be a machine…(Descartes, 1641)     

幼儿看图叙述中心理状态术语的使用与错误信念理解关系的短期跟踪研究

摘 要：为探明汉语儿童看图叙述中心理状态术语的应用及与错误信念理解能力的关系,并追踪二者相互作用的方向,本研究以101名3-5岁儿童为研究对象,纵向探查了前后相隔3个月的儿童看图叙述中心理状态术语使用情况和错误信念能力的发展状况,并从横向和纵向两个时间点分别探讨了心理状态术语的运用与错误信念理解的关系。结果表明：3-5岁儿童错误信念理解能力快速发展;儿童看图叙述中使用较多的愿望术语和情绪术语,信念术语应用相对较少,且认知词汇类型较少。控制了一般语言能力和年龄之后,仅在第一次测验上,情绪术语、信念术语仍然与同期及后期错误信念理解能力存在显著相关。