A Clinical Comparative Study Evaluating the Effect of Epilepsy Versus Adhd on Timed Cognitive Tasks in Children

Both children with epilepsy and children with ADHD may be characterized by slowing on reaction-time measurement. This is of particular interest, as neuropsychological assessment is often requested in the differential diagnosis between children with short non-convulsive epileptic seizures and children with ADHD. In this study we attempt to identify patterns of impairment on timed tasks that are specific for epilepsy, relative to ADHD. This study was an open, controlled parallel-group clinical investigation which included two groups of patients: 60 children with ADHD and 60 children with epilepsy. These children were compared with a control group (n =30) on two types of timed cognitive tasks: tasks with low information load (simple reaction-time measurement) and tasks with high information load (multiple decision reaction-time measurement). The simple reaction-time measurements show significant differences between ADHD and controls (all except for visual RT non-dominant hand) and between epilepsy and controls (only one test). No significant differences were found between epilepsy and ADHD. The two tests with high information load show significant slowing compared with the controls for epilepsy on the Binary Choice Reaction-Time Test and for ADHD on the Visual Searching Test. On both tests also the differences between epilepsy and ADHD are significant. The two tests in combination have a relatively satisfactory potential to classify the children with ADHD (75% correct classification) and the children with epilepsy (55% correct classification). We may conclude that complex reaction-time tests (i.e., timed tasks with high information load) have potential for assessing the differential impact of ADHD and epilepsy on attentional function. These tasks specifically reveal general slowing for children with epilepsy and slowing as an effect of failures of inhibitory self control on unstructured tasks for ADHD.     

The Efficacy of Toddler-Parent Psychotherapy for Fostering Cognitive Development in Offspring of Depressed Mothers

The efficacy of Toddler-Parent Psychotherapy (TPP) as a preventive intervention for fostering cognitive development in the offspring of depressed mothers was evaluated. Mothers with major depressive disorder and their toddlers were randomly assigned to TPP (n = 43) or to a nonintervention group (n = 54) and compared to a control group (n = 61) of women with no current or past mental disorder. At baseline (age 20 months), the groups did not differ on the Bayley Mental Development Index. At post-intervention follow-up (age 3 years), a relative decline in IQ was found in the depressed nonintervention group, whereas the depressed intervention and the normal control groups continued to be equivalent, with higher WPPSI-R Full Scale and Verbal IQs. The worst outcome was found among nonintervention children whose mothers had subsequent depressive episodes. The results confirm the developmental risks faced by offspring of depressed mothers and support the efficacy of the preventive intervention in safeguarding successful cognitive development in at-risk youngsters.     

中西医结合发展前景的展望

中西医结合的一个很重要的内容是中西医的兼容问题,包括交叉兼容、中西互补、结合创新。目前,中西医结合面临着强大现代医学的挑战,及理论研究、中药现代化、人才培养等方面的困难。能否处理好中西医的兼容问题及面临的困难,将直接影响到２１世纪中西医结合的发展。     

Schizophrenia Epigenesis?

I begin by examining how genetics drivesschizophrenia research, and raise both familiar andrelatively novel criticisms of the evidence putativelysupporting the genetic basis of schizophrenia. Inparticular, I call attention to a set of concernsabout the effects of placentation on concordance ratesof schizophrenia in monozygotic twins, which furtherweakens the case for schizophrenia's so-called stronggenetic component. I then underscore two criticalpoints. First, I emphasize the importance of takingseriously considerations about the complexity of bothontogenesis and the development of hereditarydiseases. The recognition of developmentalconstraints and supports is crucial, for attention todevelopment exposes the naivete of too many models ofgene action in the aetiology of disease. Secondly, Iattend to those schizophreniologists who ignoremethodological criticisms and thus presume a geneticbasis for schizophrenia, and then seek the schizophrenic genotype lacking an adequatephenotype. In response I attempt to demonstrate thenecessity of a sustained effort at characterizing thephenotype of schizophrenia as an enabling conditionfor the whole enterprise of psychiatric genetics – andfor psychiatry itself. Without the organism-levelphenotype, research at the level of genes will remainunproductive – assuming of course that research at thegenetic level is appropriate at all.     

儿童早期"心理理论"发展研究中的几个基本问题

儿童"心理理论"的发展研究是当今发展心理学中最活跃的领域之一.近年来,该领域的研究重点已逐渐由一般的发展描述,转向关于"心理理论"的缘起与发展机制的研究.由此,有许多密切相关的关于早期"心理理论"发生发展及其评估的基本问题,横亘于研究者面前,迄今仍悬而未决,并引发诸多争议.如何解决这些问题并理顺它们之间的关系,将极大地影响着该领域今后的研究进展.     

The Ecological Self: Metaphor and Developmental Experience?

The term ecological self, used within the fields of deep ecology and ecopsychology, is considered here from the viewpoint of developmental research and theory, within the context of contemporary relational psychoanalysis. Both developmental theory and more specifically our concept of health are explored with the inclusion of relatedness to the nonhuman world and an emphasis on embodiment and interactive experience. Illustrations and examples are drawn from research, clinical work with adults and the literature of natural history.     

Infant recall memory and communication predicts later cognitive development

This longitudinal study investigates the relation between recall memory and communication in infancy and later cognitive development. Twenty-six typically developing Swedish children were tested during infancy for deferred imitation (memory), joint attention (JA), and requesting (nonverbal communication); they also were tested during childhood for language and cognitive competence. Results showed that infants with low performance on both deferred imitation at 9 months and joint attention at 14 months obtained a significantly lower score on a test of cognitive abilities at 4 years of age. This long-term prediction from preverbal infancy to childhood cognition is of interest both to developmental theory and to practice.     

The effect of cues on young children's abilities to discriminate among thoughts, feelings and behaviours

OBJECTIVE: To determine if cues help young children discriminate among thoughts, feelings and behaviours. PARTICIPANTS: Ninety-six children aged 4-7 years from three schools in Norwich, UK. DESIGN: Within each age band (4, 5, 6, 7), children were randomised to the cue or the no cue condition on a stratified basis ensuring that equal numbers of boys and girls from each school were in each of the eight cells (cue condition x age). Cues were glove puppets and post boxes. The effect of IQ was controlled. MEASURES: A discrimination task, in which children were asked to identify a thought, a feeling and a behaviour from each of six brief stories, and a brief IQ assessment were administered to children individually. RESULTS: There was a significant effect of age and cue condition on performance; older children and those who were presented with the cue performed better. There were no gender differences and no interaction between cue condition and age. CONCLUSION: Many young children discriminated among thoughts, feelings and behaviours suggesting that they may be able to engage in this aspect of cognitive behaviour therapy. Simple cues (puppets and posting boxes) improved children's performance and these may be useful therapeutic tools with young children.     

Developmental dyscalculia and basic numerical capacities: a study of 8-9-year-old students

Thirty-one 8- and 9-year-old children selected for dyscalculia, reading difficulties or both, were compared to controls on a range of basic number processing tasks. Children with dyscalculia only had impaired performance on the tasks despite high-average performance on tests of IQ, vocabulary and working memory tasks. Children with reading disability were mildly impaired only on tasks that involved articulation, while children with both disorders showed a pattern of numerical disability similar to that of the dyscalculic group, with no special features consequent on their reading or language deficits. We conclude that dyscalculia is the result of specific disabilities in basic numerical processing, rather than the consequence of deficits in other cognitive abilities.     

Six does not just mean a lot: preschoolers see number words as specific

This paper examines what children believe about unmapped number words - those number words whose exact meanings children have not yet learned. In Study 1, 31 children (ages 2-10 to 4-2) judged that the application of five and six changes when numerosity changes, although they did not know that equal sets must have the same number word. In Study 2, 15 children (ages 2-5 to 3-6) judged that six plus more is no longer six, but that a lot plus more is still a lot. Findings support the hypothesis that children treat number words as referring to specific, unique numerosities even before they know exactly which numerosity each word refers to.