What Do Women Want? A New View of Women’s Sexual Problems

Recent attempts to medicalize women’s sexual “dysfunction” are critiqued and a “New View” of women’s sexual problems is introduced. The author argues for a female-centered perspective on women’s sexual desires and problems, based on a review of the literature on women’s sexuality and her observations of young women’s sexual experiences from 25 years of teaching Human Sexuality to undergraduate women. The review suggests that a pill or a patch cannot adequately address the sexual problems commonly experienced by US women.     

Neural modeling and imaging of the cortical interactions underlying syllable production

This paper describes a neural model of speech acquisition and production that accounts for a wide range of acoustic, kinematic, and neuroimaging data concerning the control of speech movements. The model is a neural network whose components correspond to regions of the cerebral cortex and cerebellum, including premotor, motor, auditory, and somatosensory cortical areas. Computer simulations of the model verify its ability to account for compensation to lip and jaw perturbations during speech. Specific anatomical locations of the model's components are estimated, and these estimates are used to simulate fMRI experiments of simple syllable production.     

The social function of imitation in severe dementia

We report the case of Jessie, an individual with severe Alzheimer's disease. Over two sessions, we examine Jessie's spontaneous conversation behaviour and urge to communicate using the ‘still face’ paradigm. Spontaneous and deliberate imitation are also examined to identify their importance in social interactions in severe dementia. Although Jessie has difficulty producing meaningful conversation, she retains the urge to communicate and participate in social interactions. These results confirm the importance of imitation in facilitating and maintaining people with communication problems in the social world. Copyright © 2006 John Wiley & Sons, Ltd.     

非传统理念指导下的传统技术导致应用医学重大课题的突破--关于2005年诺贝尔生理学或医学奖

发现幽门螺杆菌(Helicobacter pylori,以下简称Hp)导致慢性胃炎和消化性溃疡,是沃伦和马歇尔获得2005年诺贝尔医学奖的原因.他们在1982年得出的这一假说,违反了关于这一类慢性病传统的发病机制理念.可能因为这一理念的反传统性,其假说被世界同行基本接受大概经历了20年时间.值得强调的是,对HP的观察、分离、培养、鉴定和人体试验,以及它与疾病相关的诊断、治疗、临床流行病学等研究,应用的都是传统的医学技术.从而表明,即使到了20世纪80年代,传统技术仍能导致诺贝尔奖级科研成果的出现.     

Perceived Stress and Comorbid Illness Predict Depressive Symptomatology in People with Coeliac Disease

A high prevalence of depression is found in people with coeliac disease (CD). People with CD who are depressed are less likely to manage their illness effectively, which may lead to complications. Identification of variables associated with depression in people with CD may facilitate early detection and intervention. Participants were 749 members (125 males, 622 females) of the Queensland Coeliac Society (aged 18–88 years), recruited via a mailout. Participants completed the Modified Zung Self‐Rating Depression Scale, the Perceived Stress Scale, and the Perceived Consequences Subscale (from the Revised Illness Perception Questionnaire). Stress (p = .001) and comorbid medical illness (p = .01) were significantly associated with depression in CD. The current study made an original contribution to the body of literature by identifying stress and comorbid medical illness as predictors of depression in CD.     

Parkinsonian Patients Reduce Their Stroke Size with Increased Processing Demands

Parkinson's disease (PD) patients often show reductions in writing size (micrographia) as the length of the text they produce increases. The cause for these reductions in stroke size are not well understood. Reductions in stroke size could be associated with either concurrent processing demands that result from the coordination and control of fingers, wrist, and arm during writing and the processing of future words or increased extension of the wrist joint as the execution of the writing progresses to the right across the page, resulting in increased stiffness in the pen-limb system. Parkinson's patients and elderly controls wrote phrases of different lengths with target patterns in various serial positions. When the number of words to be written increased, PD patients reduced their stroke size of the initial target pattern, while the elderly controls did not reduce their stroke size. There was no systematic change in stroke size of the second pattern as function of serial position. This result suggests that PD patients reduce the size of their handwriting strokes when concurrent processing load increases.     

循证医学及其在心血管疾病中的应用

循证医学作为一门新兴的学科,对医学的研究和实践将产生越来越大的影响。在循证医学的操作过程中,如何正确评价和应用所获得的证据极为重要。在短短的十几年间,循证医学给心血管疾病的临床实践带来了根本的变化。     

Evidence of Impaired Glucose Tolerance and Insulin Resistance in Patients With Alzheimer’s Disease

Alzheimer’s disease (AD) and diabetes rarely occur together, a finding that provides a possible clue as to the development of AD. Abnormal glucose metabolism is not limited to diabetes, but also can include impaired glucose tolerance, insulin resistance, and hyperinsulinemia. AD patients have significantly varying insulin levels after drinking sugared sodas and thus may be classified as insulin resistant. After reviewing the literature on impaired glucose tolerance and insulin production in AD, we present several hypotheses as possible explanations for the relationship between insulin resistance and AD. Finally, we suggest future studies, including studies on use of thiazolidinediones (currently used in the treatment of diabetes) in AD.     

对影响病人满意度相关因素的医学伦理思考

设计调查问卷对深圳某基层医院实施病人满意度调查及相关因素的医学伦理分析。结果显示病人满意度不高,门急诊病人的总满意度明显低于住院病人;病人对服务态度、就医环境和诊疗费用等都较不满意。其中医院未能遵循及时、准确、有效、择优和自主原则是主要影响因素。     

Relation of occupational knowledge to career interests and competence perceptions in Italian children

The relations of differential occupational knowledge with interests and competence perceptions in children as well as how these relations were moderated by gender and grade were examined in this study using an Italian sample. Data were collected from samples of elementary school and middle school children (N = 539). The Inventory of Children's Activities—Revised (ICA-R; Tracey & Ward, 1998) was used to assess children's interest and competency perceptions in various activities associated with the Holland's RIASEC types. The Occupational Knowledge Scale (OKS) was created for this study, and consisted of a representative sampling of occupational titles to which children indicated their knowledge. Hierarchical regression results indicated a relationship between knowledge, interests, and competence perceptions in children. With regard to overall knowledge, no relationship was found between general knowledge and either grade or gender. More specific examination of the type of knowledge as it varied across the dimensions of People–Things, and Data–Ideas demonstrated that there appeared to be a specific pattern relating interest, gender, and grade to knowledge of occupations. For knowledge of people relative to things occupations, higher interest, higher grade level, and being female predicts stronger knowledge of people occupations. It was also found that interest in ideas predicts stronger knowledge of ideas occupations, and being male predicts stronger knowledge of high prestige occupations. Generally, competence perceptions did not have a unique relation with one's knowledge of People–Things, Ideas–Data, or Prestige; however, girls who reported higher competence had greater knowledge of ideas occupations.