前列腺素E2及其在肾脏调控中的作用

前列腺素E2(PGE2)是最主要的前列腺素化合物,参与几乎所有的细胞代谢活动并介导多种不同的生理病理功能。PGE2的生物学效应是通过与不同的EP受体结合从而激活不同的信号转导通路来实现的。因为各类EP受体在肾脏的高分布,所以近来PGE2在肾脏中的作用日趋引起人们的重视。     

A Computer Scientist's Perspective on Chaos and Mystery

James E. Huchingson's Pandemonium Tremendum draws on a surprisingly fruitful analogy between metaphysics and thermodynamics, with the latter motivated through the more accessible language of communication theory. In Huchingson's model, God nurtures creation by the selective communication of bits of order that arise spontaneously in chaos.     

Vers une nouvelle appréhension des mathématiques par traitement EMDR : actualités et perspectives

ObjectiveEMDR for Eye Movement Desensitization and Reprocessing developed since 1989 by F. Shapiro has demonstrated its effectiveness in the treatment of Post Traumatic Stress Disorder (PTSD). In Science of Education, no study has been previously developed in the application of EMDR protocols. The purpose of this article is to demonstrate the relevance and effectiveness of EMDR in supporting cognitive and emotional remediation of students in Master 1, with respect to mathematics, preparing Schools Teacher contest. The first encounters with the students revealed, through their discourse, an aversion to mathematics linked to one or more particularly painful experiences in a learning situation. Mathematics may cause anguish, sometimes tinged beliefs such as “I’ll never be able to… I am very bad at math”. This represents even an insurmountable obstacle in the professional life of some.MethodsNearly 170 students in Master 1 “Professor of the Schools” registered on the ESPE (College of the Teaching profession and Education) were asked about their relation to mathematics, both in their emotions as their self-efficacy. Among those who suggested a traumatic memory in a learning situation in mathematics, forty were selected and divided into two groups. The control group received two hours of information about relaxation techniques that could be used before mathematics. The other group benefited of the EMDR treatment according to the standard protocol in eight phases.ResultsThe results showed that students who received EMDR treatment experienced after treatment and one month later, a significant decline in their negative emotions with mathematics and an increase in the strength of their self-efficacy, unlike the control group.DiscussionEMDR demonstrates its effectiveness in reprocessing beliefs and emotions of students with respect to mathematics and opens ways of research in Educational Sciences. So, it will be necessary, from the principle of alternated bilateral stimulation, to develop specific protocols for the struggling students, to measure the effects in the long term and develop them in a group situation.     

Women's self-estimates of competence and the resolution of the career/home conflict

Relationships among women's role factors, self-estimates of competence, and career commitment were investigated. Eighty female business students and 111 business alumnae completed the Attitudes Toward Women Scale, the Performance-Self-Esteem Scale (PSES), and questions regarding home and career choices. As predicted, PSES scores were related to extent of career commitment, and PSES scores mediated the relationship between career commitment and women's role factors. Among high PSES subjects, career commitment was positively related to nontraditional sex-role attitudes and negatively related to family involvement. Among low PSES subjects, the relationship between career commitment and women's role factors was weaker. Implications for women's career development are discussed.