Task-related factors in oral motor control: speech and oral diadochokinesis in dysarthria and apraxia of speech

This study was focused on the potential influence of task-related factors on oral motor performance in patients with speech disorders. Sentence production was compared with a nonspeech oral motor task, i.e., oral diadochokinesis. Perceptual and acoustic measures of speech impairment were used as dependent variables. Between-task comparisons were made for subsamples of a population of 140 patients with different motor speech syndromes, including apraxia of speech and cerebellar dysarthria. In a further analysis subgroups were matched for speaking rate. Overall, dysdiadochokinesis was correlated with the degree of speech impairment, but there was a strong interaction between task type and motor speech syndrome. In particular, cerebellar pathology affected DDK to a relatively greater extent than sentence production, while apraxic pathology spared the ability of repeating syllables at maximum speed.     

Neuronal changes in normal human aging and Alzheimer's disease

This article discusses age-related changes in brain weight, total number of cortical neurons, cortical dendrites, spine, and synapse density. The conclusion is that the present outlook is less grim than it was 30 years ago. Age-related reduction appears to be specific to brain region and cortical layer rather than a general feature. In addition, we describe a different pattern of changes that occur in Alzheimer's disease patients. This review concludes that the association cortices in particular are affected in aging and Alzheimer's disease and that the primary visual and somatosensory cortices are relatively spared.     

Lapses of intention and performance variability reveal age-related increases in fluctuations of executive control

We examine the hypothesis that the efficiency of executive control processes is less stable over time in older than younger adults. An age-related decrease in the efficiency of executive control should result in an increase in performance variability in task conditions requiring the recruitment of executive control processes and not in task conditions requiring minimal involvement of executive control. Performance variability was similar for younger and older adults in task conditions requiring minimal executive control and greater for older than younger adults in task conditions requiring executive control. These and other data are consistent with the proposal that aging is associated with a decrease in the stability of executive control over time.     

Effects of methylphenidate on sensitivity to reinforcement in children diagnosed with attention deficit hyperactivity disorder: an application of the matching law

The behavior of children diagnosed with attention deficit hyperactivity disorder (ADHD) has been hypothesized to be the result of decreased sensitivity to consequences compared to typical children. The present study examined sensitivity to reinforcement in 2 boys diagnosed with ADHD using the matching law to provide more precise and quantitative measurement of this construct. This experiment also evaluated the effects of methylphenidate (MPH) on sensitivity to reinforcement of children with ADHD. Subjects completed math problems to earn tokens under four different variable-interval (VI) schedules of reinforcement presented in random order under both medicated and nonmedicated conditions. Results showed that, in the medicated condition, the matching functions for both subjects resulted in higher asymptotic values, indicating an overall elevation of behavior rate under these conditions. The variance accounted for by the matching law was also higher under the medicated conditions, suggesting that their behavior more closely tracked the changing rates of reinforcement while taking MPH compared to placebo. Under medicated conditions, the reinforcing efficacy of response-contingent tokens decreased. Results are discussed with respect to quantifying behavioral changes and the extent to which the drug interacts with prevailing contingencies (i.e., schedule values) to influence behavioral variability.     

A comparison of verbal and tangible stimulus preference assessments

Tangible preference assessments were compared with verbal preference assessments for 6 individuals with mental retardation, behavior disorders, or both. In the tangible assessment, items were placed in front of the participant. In the verbal assessment, participants were asked, “Do you want X or Y?” and the items were not present. The two assessments yielded similar high‐preference items for 4 of the 6 participants. The verbal assessment was typically completed in less time than the tangible assessment.     

Preference and resistance to change with constant-duration schedule components

Previous research on preference between variable-interval terminal links in concurrent chains has most often used variable-duration terminal links ending with a single reinforcer. By contrast, most research on resistance to change in multiple schedules has used constant-duration components that include variable numbers of reinforcers in each presentation. Grace and Nevin (1997) examined both preference and resistance in variable-duration components; here, preference and resistance were examined in constant-duration components. Reinforcer rates were varied across eight conditions, and a generalized-matching-law analysis showed that initial-link preference strongly over-matched terminal-link reinforcer ratios. In multiple schedules, baseline response rates were unaffected by reinforcer rates, but resistance to intercomponent food, to extinction, and to intercomponent food plus extinction was greater in the richer component. The between-component difference in resistance to change exhibited additive effects for the three resistance tests, and was systematically related to reinforcer ratios. However, resistance was less sensitive to reinforcer ratios than was preference. Resistance to intercomponent food and to intercomponent food plus extinction was more sensitive to reinforcer ratios in the present study than in Grace and Nevin (1997). Thus, relative to variable-duration components, constant-duration components increased the sensitivity of both preference and relative resistance, supporting the proposition that these are independent and convergent measures of the effects of a history of reinforcement.     

Equivalence relations and the reinforcement contingency

Where do equivalence relations come from? One possible answer is that they arise directly from the reinforcement contingency. That is to say, a reinforcement contingency produces two types of outcome: (a) 2‐, 3‐, 4‐, 5‐, or n‐term units of analysis that are known, respectively, as operant reinforcement, simple discrimination, conditional discrimination, second‐order conditional discrimination, and so on; and (b) equivalence relations that consist of ordered pairs of all positive elements that participate in the contingency. This conception of the origin of equivalence relations leads to a number of new and verifiable ways of conceptualizing equivalence relations and, more generally, the stimulus control of operant behavior. The theory is also capable of experimental disproof.     

From case management to prevention of scientific dishonesty in Denmark

In 1992, The Danish Medical Research Council established a national committee on scientific dishonesty with the twofold task of handling cases of scientific misconduct and taking preventive initiatives. Scientific dishonesty was proven in only five cases, but in another nine cases lesser degrees of deviations from good scientific practice were found. The experiences from a total of 24 treated cases indicated that three key areas were at the basis of most of the accusations and the deviations from good practice: uncertainty about 1) authorship, about 2) rights and duties to use scientific data and about 3) agreements at the initiation of joint studies. As a consequence guidelines on good practice have been issued on these key subjects. An earlier version of this paper was presented at a symposium, Scientific Misconduct. An International Perspective, organised by The Medical University of Warsaw, 16 November, 1998.     

Sentence processing deficits in two Cantonese aphasic patients

This paper reports the performances of two Cantonese aphasics on tasks examining their sentence processing deficits. The data on sentence comprehension show that thematically noncanonical sentences, full passives, and subject-gap sentences present greater difficulty to these patients than canonical sentences, truncated passives, and object-gap sentences, respectively. These patterns are consistent with previous observations on Chinese aphasics and are expected given the structural differences between Chinese and English. In a Cantonese grammaticality judgment test, a set of structures are identified that can elicit clear judgments from normal subjects and aphasics, contrary to the claim that grammaticality judgments in Chinese are probabilistic and fragile. Most interestingly, the patients' overall performance patterns reveal a double dissociation between sentence comprehension and judgment of sentence well-formedness, suggesting that the two tasks are supported by independent processing mechanisms.