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131.
Jeffrey A. Kleim Michelle A. Pipitone Cheryl Czerlanis William T. Greenough 《Neurobiology of learning and memory》1998,69(3):290-306
Complex motor learning, but not mere motor activity, has been previously shown to induce structural modifications within the cerebellar cortex. The present experiment examined whether similar changes occur within one of the primary output targets of the region of the cerebellar cortex in which these structural changes were described, the lateral cerebellar nucleus (LCN; dentate nucleus). Adult female rats were randomly allocated to one of three training conditions. Acrobatic condition (AC) rats were trained to complete a complex motor learning task consisting of a series of elevated obstacles while motor control (MC) condition animals were forced to traverse a flat obstacle-free runway equal in length to the AC task. Inactive condition (IC) animals received no motor training. Unbiased stereological techniques and electron microscopy were used to obtain estimates of synapse number and postsynaptic density (PSD) length within the LCN. Results showed that neither synapse number nor PSD length was significantly altered as a function of training condition. These results indicate that complex motor skill learning is associated with structural plasticity within the cerebellar cortex and with structural stability within the lateral cerebellar nucleus. 相似文献
132.
The conflict adaptation (CA) effect refers to the reduction in the interference effect observed in conflict tasks that follow incongruent compared to congruent trials. It has been suggested that CA is caused by the exertion of flexible cognitive control, supported by many behavioral and neuroimaging studies; however, it remains unclear how conflict‐related features of the preceding trial are conveyed to subsequent trials for following adaptation. This review aims to summarize evidence supporting the top‐down modulation of the dorsolateral prefrontal cortex and passive short‐term maintenance in the posterior brain areas as mechanisms underlying CA, respectively, and to suggest a new integrated view of CA, including active maintenance in working memory. We review empirical evidences suggesting that both dorsolateral prefrontal cortex and posterior brain regions play critical roles in CA, rather than either top‐down modulation or passive maintenance alone. Although the active maintenance view of CA appears to explain many existing findings, empirical studies are required to directly test this view. 相似文献
133.
Our purpose was to examine changes in single-leg landing biomechanics and movement control following alterations in mechanical task demands via external load and landing height. We examined lower-extremity kinematic, kinetic, and electromyographic (EMG) adjustments, as well as changes in movement control from neuromechanical synergies using separate principal component analyses (PCA). Nineteen healthy volunteers (15M, 4F, age: 24.3 ± 4.9 y, mass: 78.5 ± 14.7 kg, height: 1.73 ± 0.08 m) were analyzed among 9 single-leg drop landing trials in each of 6 experimental conditions (3 load and 2 landing height) computed as percentages of subject bodyweight (BW, BW + 12.5%, BW + 25%) and height (H12.5% & H25%). Condition order was counterbalanced, including: 1.) BW·H12.5, 2.) BW + 12.5·H12.5, 3.) BW + 25·H12.5, 4.) BW·H25, 5.) BW + 12.5·H25, 6.) BW + 25·H25. Lower-extremity sagittal joint angles and moments (hip, knee, & ankle), vertical ground reaction force (GRFz), and electrical muscle activity (gluteus maximus, biceps femoris, vastus medialis, medial gastrocnemius, & tibialis anterior muscles), were analyzed in each trial. Biomechanical adjustments and neuromechanical synergies were assessed using PCA. Subjects reduced effective landing height through segmental configuration adjustments at ground contact, extending at the hip and ankle joints with greater load and landing height (p ⩽ 0.028 and p ⩽ 0.013, respectively), while using greater medial gastrocnemius pre-activation with greater load (p ⩽ 0.006). Dimension reduction was observed under greater mechanical task demands, compressing and restructuring synergies among patterns of muscle activation, applied loads, and segmental configurations. These results provide insight into movement control and potential injury mechanisms in landing activities. 相似文献
134.
People with multiple sclerosis (MS) complain of problems completing two tasks simultaneously; sometimes called ‘dual-tasking’ (DT). Previous research in DT among people with MS has focused on how adding a cognitive task interferes with gait and few have measured how adding a motor task could interfere with cognition. We aimed to determine the extent to which walking affects a concurrent working memory task in people with MS compared to healthy controls. We recruited MS participants (n = 13) and controls (n = 10) matched by age (±3 years), education (±3 years) and gender. Participants first completed the cognitive task (subtracting 7’s from the previous number) and then again while walking on an instrumented walkway. Although there were no baseline differences in cognition or walking between MS participants and controls, MS participants demonstrated a 52% decrease in number of correct answers during DT (p < 0.001). Mental Tracking Rate (% correct answers/min) correlated strongly with MS-related disability measured using the Expanded Disability Status Scale (EDSS; r(11) = −0.68, p < 0.01). We propose that compromised mental tracking during walking could be related to limited neural resource capacity and could be a potentially useful outcome measure to detect ecologically valid dual tasking impairments. 相似文献
135.
ObjectiveChildren with Developmental Coordination Disorder demonstrate a lack of automaticity in handwriting as measured by pauses during writing. Deficits in visual perception have been proposed in the literature as underlying mechanisms of handwriting difficulties in children with DCD. The aim of this study was to examine whether correlations exist between measures of visual perception and visual motor integration with measures of the handwriting product and process in children with DCD.MethodThe performance of twenty-eight 8–14 year-old children who met the DSM-5 criteria for DCD was compared with 28 typically developing (TD) age and gender-matched controls. The children completed the Developmental Test of Visual Motor Integration (VMI) and the Test of Visual Perceptual Skills (TVPS). Group comparisons were made, correlations were conducted between the visual perceptual measures and handwriting measures and the sensitivity and specificity examined.ResultsThe DCD group performed below the TD group on the VMI and TVPS. There were no significant correlations between the VMI or TVPS and any of the handwriting measures in the DCD group. In addition, both tests demonstrated low sensitivity.ConclusionClinicians should execute caution in using visual perceptual measures to inform them about handwriting skill in children with DCD. 相似文献
136.
Motor symptomatology in autism is currently poorly understood, and still not included in the autism spectrum disorder (ASD) diagnostic criteria, although some studies suggest the presence of motor disturbances in this syndrome. We provide here a literature review on early motor symptoms in autism, focusing on studies on psychomotor issues (tone, postural control, manual dexterity, handedness, praxis). The approach adopted in research to study altered motor behaviors is generally global and there is no detailed semiology of the motor or neuromotor disorders observed in people with ASD. This global approach does not enable understanding of the neuro-developmental mechanisms involved in ASD. Identification of clinical neuro-psychomotor profiles in reference to a standard would help to better understand the origin and the nature of the disorders encountered in ASD, and would thus give new directions for treatment. 相似文献
137.
138.
Route learning in Korsakoff's syndrome: Residual acquisition of spatial memory despite profound amnesia 下载免费PDF全文
Erik Oudman Stefan Van der Stigchel Tanja C.W. Nijboer Jan W. Wijnia Maaike L. Seekles Albert Postma 《Journal of Neuropsychology》2016,10(1):90-103
Korsakoff's syndrome (KS) is characterized by explicit amnesia, but relatively spared implicit memory. The aim of this study was to assess to what extent KS patients can acquire spatial information while performing a spatial navigation task. Furthermore, we examined whether residual spatial acquisition in KS was based on automatic or effortful coding processes. Therefore, 20 KS patients and 20 matched healthy controls performed six tasks on spatial navigation after they navigated through a residential area. Ten participants per group were instructed to pay close attention (intentional condition), while 10 received mock instructions (incidental condition). KS patients showed hampered performance on a majority of tasks, yet their performance was superior to chance level on a route time and distance estimation tasks, a map drawing task and a route walking task. Performance was relatively spared on the route distance estimation task, but there were large variations between participants. Acquisition in KS was automatic rather than effortful, since no significant differences were obtained between the intentional and incidental condition on any task, whereas for the healthy controls, the intention to learn was beneficial for the map drawing task and the route walking task. The results of this study suggest that KS patients are still able to acquire spatial information during navigation on multiple domains despite the presence of the explicit amnesia. Residual acquisition is most likely based on automatic coding processes. 相似文献
139.
Denise C.C. Santos Carl Gabbard Vanda M.G. Goncalves 《Infant and child development》2000,9(3):161-166
This investigation documents the pattern of motor development of Brazilian infants over the first 6 months and compares the findings with a US norm. Infants were assessed once each month for the 6‐month period using the Bayley II Motor Scale, which represented the US norm for comparison. Participants monthly scores increased with age and were similar to the US profile. However, the Brazilian infants did exhibit mean scores significantly lower than their counterparts on tasks of sitting and grasping in the 3rd, 4th, and 5th month; at the 6th month, scores were comparable. Explanations for differences focus on possible cross‐cultural and maturational influences. Copyright © 2000 John Wiley & Sons, Ltd. 相似文献
140.
Loukia D. Loukopoulos Sascha E. Engelbrecht Neil E. Berthier 《Journal of motor behavior》2013,45(3):255-264
Individuals are assumed to plan reach-and-grasp movements by using two separate processes. In 1 of the processes, extrinsic (direction, distance) object information is used in planning the movement of the arm that transports the hand to the target location (transport planning); whereas in the other, intrinsic (shape) object information is used in planning the preshaping of the hand and the grasping of the target object (manipulation planning) In 2 experiments, the authors used primes to provide information to participants (N = 5, Experiment 1; N = 6, Experiment 2) about extrinsic and intrinsic object properties. The validity of the prime information was systematically varied. The primes were succeeded by a cue, which always correctly identified the location and shape of the target object. Reaction times were recorded. Four models of transport and manipulation planning were tested. The only model that was consistent with the data was 1 in which arm transport and object manipulation planning were postulated to be independent processes that operate partially in parallel. The authors suggest that the processes involved in motor planning before execution are primarily concerned with the geometric aspects of the upcoming movement but not with the temporal details of its execution. 相似文献