幽门螺杆菌cagA基因多态性对临床结局的影响：东亚菌株和西方菌株

CagA蛋白是幽门螺杆菌最重要的毒力因子之一。目前已证实cagA基因存在东亚及西方两种亚型。幽门螺杆菌产生CagA蛋白,注入胃上皮细胞后在其羧基端EPIYA重复序列区进行酪氨酸磷酸化,进而与SHP-2酪氨酸磷酸化酶相互作用,参与上皮细胞的信号传导,导致细胞骨架结构的重排,引起细胞表面形状的改变和细胞动力的增强,造成细胞异常的增殖和运动,在胃癌的发生中起了主要作用。cagA基因的羧基端EPIYA重复序列被认为是区分东亚型和西方型菌株的分子标记,东亚型CagA与SHP-2亲和力大于西方型,最终影响着不同CagA 菌株感染的临床表现。     

Cultural mediators of self-reported social anxiety

East Asians generally endorse higher social anxiety than do Westerners. Widely used measures of social anxiety, however, may not account for different social values across cultures. Drawing from Korean (n=251) and Euro-Canadian (n=250) community samples, this study used a cross-sectional design to examine the relationship between ratings of social anxiety and beliefs and self-views typically found in East Asian cultures. Results indicated that independent self-construal and identity consistency, views of the self that are typically associated with Western cultures, fully mediate the ethnic difference on self-reported social anxiety. Moreover, two indicators of East Asian views of the self in social contexts (interdependent self-construal and self-criticism) were partial mediators. Overall, the data suggest conceptualizations of pathological social anxiety may need to be revised to be useful for studying individuals in East Asian cultures.     

Holocaust Abuse

This essay reconsiders the category of “Holocaust denial” as the marked indicator of ethical transgression in Holocaust historiography within American civil religion. It maintains that the present category excludes and thereby enables other violations of responsible Holocaust historiography. To demonstrate the nature and gravity of such violations, the essay engages the widespread claim that Hajj Muhammad Amin al‐Husayni, the former mufti of Jerusalem, was an instigator, promoter, or “driving spirit” of the Nazi genocide against Jews, and the associated suggestions of wider Arab and Muslim complicity. The essay uncovers the history of the Husayni narrative in question, the dramatic circumstances in which it emerged, its role in the 1961 trial of Adolf Eichmann, and its rediscovery and misuse within American popular and political circles over the past two decades. Such misuse, it concludes, corrodes Holocaust recognition within American civil religion and demonstrates the need for a revision of the socially accepted ethical boundary for responsible Holocaust historiography.     

ROBERT JOHN RUSSELL VERSUS THE NEW ATHEISTS

This essay compares Robert John Russell's work in his recent book Cosmology from Alpha to Omega: The Creative Mutual Interaction of Theology and Science (2008) to that of the authors known collectively as "the new atheists." I treat the latter as recent contributors to the modern tradition of scientific naturalism. This tradition makes claims to legitimacy on the basis of its close relations to the natural sciences. The purpose of this essay is to show up the poverty of the naturalist tradition's scientific credentials by contrasting it with Russell's careful account of positive relations between science and Christian theology.     

心理学家Daniel Kahneman获2002年诺贝尔经济学奖

心理学家Daniel Kahneman被授予2002年诺贝尔经济学奖。他遵循1978年诺贝尔经济学奖获得者Herbert A. Simon的“有限理性”理论和启发式的思想,提出3种常见的启发式:代表性、可得性以及锚定和调整。Kahneman发现人类的决策行为常常是非理性和有偏差的,这与传统经济学理论 (期望效用理论)的预期不符,而且这种偏差是有规律的。Kahneman提出前景理论以解释人类在不确定条件下的判断和决策行为。他获得诺贝尔经济学奖是因为他“把心理学的,特别是关于不确定条件下人的判断和决策的研究思想,结合到了经济科学中。”该文列举实例简单介绍了Daniel Kahneman对心理学和经济学的贡献。     

Task-hemispheric integrity in dual task performance

A condition of task hemispheric integrity is predicted to result in a dual task situation when the central processing and response components of each task are associated exclusively with a given cerebral hemisphere. The prediction that this condition will generate more efficient time-sharing is tested in a series of four experiments. In experiment 1 the prediction is confirmed when a spatial (tracking) and verbal (letter memory search) task are time-shared, and the hand assignment to task responses is manipulated. In experiment 2 a spatial variant of the memory search is used instead of the verbal letter search, and hand assignment effects are not obtained, since when two spatial tasks are time-shared an integrity assignment is impossible. Experiment 3 validates the hemispheric lateralization of the two single task variants of the memory search task, while experiment 4 establishes the separate “spatial’ and “verbal” resource demands of the two variants by observing their differential interference with concurrent spatial and verbal tasks.     

ISLAM AND ENVIRONMENTAL ETHICS: TRADITION RESPONDS TO CONTEMPORARY CHALLENGES

Abstract. Mounting globed environmental challenges beg for cross-cultural discussions that highlight underlying cultural values regarding nature. This paper explores the insights of Islamic scholars as they examine the interaction of Islamic culture and the West. The Western worldview that separates religion and science, value and fact, in particular differs from Islamic tradition, which sees all facets of life and affairs as interconnected by virtue of their common source—the Creator. As traditional Islamic values have been abandoned to adopt modern Western technologies, environmental problems have intensified in the Muslim world. Islamic scholars urge a return to Islamic ideals that reflect a sacramental view of the physical universe, and they champion the revival of an Islamic science that synthesizes empirical study and symbolic cognition.