A meta‐analysis of serotonin metabolite 5‐HIAA and antisocial behavior

During the past 25 years, researchers have examined the relationship between neurochemical variables and antisocial behavior in human adults, but none has been studied more intensely than the serotonin metabolite 5‐hydroxyindoleacetic acid (5‐HIAA). The goal of the current study was to employ meta‐analytic procedures to quantitatively evaluate selected evidence on the relationship between 5‐HIAA and antisocial behavior. It was expected that antisocial groups would show reduced cerebrospinal fluid 5‐HIAA compared with non–antisocial groups. This study also aimed to assess moderators that could influence the relationship between 5‐HIAA and antisociality. An electronic search and strict inclusion criteria identified 20 reports used in this meta‐analysis. Results showed a significant overall mean effect size (ES = –.45, P < .05) in the direction of lowered 5‐HIAA in antisocial vs. non–antisocial groups. A significant moderating effect for age indicated that groups comprised of antisocial individuals younger than 30 years exhibited larger negative effect sizes (ES = –1.37, P < .05) than groups with older subjects (ES = –.31, P < .05). There were no moderating effects for gender, target of violence, history of suicide, and alcoholism. Age effects may help explain age‐related declines in crime. The fact that effects did not differ based on other moderating variables supports models of reduced serotonin in antisocial individuals, regardless of type of crime or psychiatric problems. Aggr. Behav. 28:299–316, 2002. © 2002 Wiley‐Liss, Inc.     

Clinical cut‐off point for the Distrust dimension of the Dimensional Clinical Personality Inventory 2 (IDCP‐2)

The Clinical Dimensional Personality Inventory 2 (IDCP ‐2) is a 206‐item self‐report tool developed for the assessment of 12 dimensions (divided into 47 factors) of personality pathology. One of the scales comprising the instrument, the Distrust scale, is intended to provide psychometric information on traits closely related to the Paranoid Personality Disorder (PPD ). In the present research, we used the Item Response Theory and the Receiver Operating Characteristic curve analysis to establish a clinical meaningful cutoff for the Distrust scale. Participants were 1,679 adults, among outpatients diagnosed with PPD , outpatients diagnosed with other PD s, and adults from the community. The Wright map revealed that outpatients were located at the very high levels on the latent continuum of the Distrust scale, with a very large effect size for the mean difference between patients and non‐patients. The ROC curve supported a cutoff at −1.00 score in theta standardization which yielded 0.87 of sensitivity and 0.54 of specificity. Findings from the present investigation suggest the IDCP ‐2 Distrust scale is useful as a screening tool of the core features of the PPD . We address potential clinical applications for the instrument and discuss limitations from the present study.     

Evidence for Free Radical-Mediated Reduction of Lymphocytic 5′-Ectonucleotidase During Stress

Previously we showed that stress and depression could result in a 50% lowering of lymphocytic 5-ectonucleotidase (NT) which could be resolved by a diet high in antioxidants. This study suggested that high levels of free radicals mediated by stress/depression may be involved in lowering NT activities. The aim of the present study was to assess whether oxygen radicals could directly affect NT and whether excess free radicals generated in stress/depression may affect tissue ascorbate stores. Exam-stressed students and depressed patients were compared respectively to these students at low stress and depressed patients on high antioxidant intakes. In this study, NT correlated positively with tissue ascorbate stores. A range of antioxidants were tested as possible inhibitors of oxy radical interaction with NT using nitroblue tetrazolium reduction to for-mazan with superoxide anion. At physiological plasma concentrations, ascorbate inhibited this reduction but dehydroascorbate, tocopherol, retinol, selenium, urate, and reduced glutathione were ineffective. Superoxide anion directly reduced lymphocytic NT activity and this effect was reversed by either 100 molar ascorbate in vitro or a high antioxidant intake in vivo. In conclusion, the low NT activities and ascorbate stores found in stressed/depressed people appear to be mediated by higher levels of free radicals reported in these subjects. These conclusions are consistent with published reports of (1) normal NT levels in melancholic patients on high antioxidant diets; (2) heightened inflammatory reponses during stress/depression; (3) low serum levels of zinc in depressed patients.     

A clinical trial of continuous, intermittent and overlearning ‘bell and pad’ treatments for nocturnal enuresis

Sixty-one enuretic children were allocated sequentially to ‘standard’, ‘intermittent’ or ‘overlearning’ bell and pad treatment. The results suggest that the ‘overlearning’ modification of standard treatment was successful in bringing about a reduction in the relapse rate. The present status and implications of research into nocturnal enuresis were discussed in the light of the results of the investigation.     

Women's reactions to discrimination from members of the same or opposite sex

The effects upon women's self-evaluations of experiencing varying severity of failure in interpersonal competition against male vs. female opponents were explored. The results supported the hypothesis that self-esteem in women is more vulnerable to interpersonal rejection from men as opposed to other women. Specifically, subjects reported lower self-esteem when severe failure was due to the actions of alleged, male opponents rather than female ones. Also, severe failure elicited less favorable self-evaluations than mild failure only when the female subjects confronted male opponents. Finally, contrary to a defensive self-presentation hypothesis, subjects did not respond to discrimination from men by presenting themselves as being discrepant from the stereotype of women. Instead, subjects who interpreted their failure as reflecting prejudice on the part of men evaluated themselves more favorably on positive traits underlying the female stereotype.     

Selective imitation of the passive construction through modeling

Six 4- to 5-yr-old subjects were exposed to five sessions in which an adult model used passive sentences to describe a set of modeling stimuli. Probe stimuli, which the subjects were asked to describe without benefit of modeling and without selective reinforcement were interspersed among modeling stimuli. A matched group of control subjects received probletrials but no modeling trials. Both groups of subjects were subsequently tested on their ability to comprehend active and passive sentence forms. Every subject in the experimental group produced passive sentences on probe trials even though there was considerable variability in the number of passives produced. No control subject produced passives. The modeling procedure increased the comprehension scores of the experimental group above those of the control group though the scores of both groups were above chance. The results were contrasted with earlier studies in which modeling was ineffective in producing passive usage and in which comprehension of the passive was not demonstrated by even older children.     

Mothers’ Dreams,Children Realities: The Case of Uprooted Families from South Lebanon

In this exploratory qualitative study, 15 mothers and 18 adolescents who, as family members of the South Lebanon Army, were uprooted from that country and now living in Israel, were interviewed separately. The mothers described their image of the adaptive adult, which stressed the positive values of loyalty to the family, orientation toward the group, respect, and acceptance of hierarchy and guided their child‐rearing goals and socialization. The children shared similar attitudes about the importance of family loyalty and orientation toward the group, but differed from their mothers with regard to the issues of respect and obedience. We discussed the notion of “liminality,” to further our understanding of the families in transition and suggest how it applies to the uprooted members of South Lebanon army. We suggest that different time orientations and contextual factors influence the participating mothers’ image of the adaptive adult and the degree to which their children accept it. Implications for research and interventions are also explored.