CHRM3基因与孤独症谱系障碍

孤独症谱系障碍是一类具有遗传基础的儿童发展障碍疾病。近些年, 研究者们从分子病理学层面发现中枢胆碱能神经系统异常与孤独症患者认知和行为异常存在相关性。尸检研究、临床案例、动物模型研究均发现毒蕈碱型(M型)乙酰胆碱受体异常和孤独症的发生有着密切的关系。在以小鼠为模型的行为学研究中, 编码毒蕈碱型乙酰胆碱受体Ⅲ亚型的CHRM3基因突变会导致小鼠出现认知障碍、刻板行为等孤独症样表现。深入了解CHRM3基因的功能将能够帮助研究者进一步解释孤独症的相关行为特征, 为孤独症儿童教育方案的制定提供新的思路和方法。     

3D analysis of the body center of mass in rock climbing

The purpose of the present study was to search for common patterns and for differences in climbing strategies in a group of recreational climbers. Twelve participants were involved in the study. Each participant climbed a simple indoor route consisting of a 3m horizontal shift followed by a 3m ascent for five times. Climbers could choose their own style, their preferred speed and holds. Their motion was recorded through motion capture based on passive markers. Results suggested that two main climbing strategies were used: the first preferring agility over force and the second preferring force over agility. We also found that our best climbers tried to minimize power during all trials.     

Differences in visual orienting between persons with Down or fragile X syndrome

The voluntary and reflexive orienting abilities of persons with Down syndrome and fragile X syndrome, at average MA levels of approximately 4 and 7 years, were compared with an RT task. Reflexive orienting abilities appeared to develop in accordance with MA for the participants with Down syndrome but not for those with fragile X syndrome. However, both groups showed delayed voluntary orienting. The group differences in reflexive orienting at the low MA level reinforce the practice of separating etiologies and highlight the contribution of rudimentary attentional processes in the study of individuals with mental retardation.     

Is Theory of Mind Understanding Impaired in Males with Fragile X Syndrome?

Males with fragile X syndrome (FXS) have difficulties with social interaction and many show autistic features. This study examined whether the social deficits characteristic of FXS are associated with theory of mind difficulties. Two groups of boys with FXS participated: a group with few autistic features and a group with many autistic features. An intellectual disability control group also participated. In addition to using standard theory of mind tasks, new techniques were used that were able to separate out the various processing demands of the task (e.g., memory, inhibitory control). Overall, the findings indicate that both groups of boys with FXS have difficulty with theory of mind tasks compared to an intellectual disability control group. However, both groups with FXS also performed worse on comparison trials that required working memory but not theory of mind. Theory of mind difficulties are likely to be an important aspect of the FXS clinical profile, but are most likely the result from a more basic difficulty with working memory.     

Widgets: A new set of parametrically defined 3D objects for use in haptic and visual categorization tasks

IntroductionMost research to date on human categorization ability has concentrated on the visual and auditory domains. However, a limited – but non-negligible – range of studies has also examined the categorization of familiar or unfamiliar (i.e., novel) objects in the haptic (i.e., tactile-kinesthetic) modality.ObjectiveIn this paper, we describe how we developed a new set of parametrically defined objects, called widgets, that can be used as 3D (or 2D) materials for haptic (or visual) categorization purposes.MethodWidgets are unfamiliar complex 3D shapes with an ovoid body and four types of elements attached to it (eyes, tail, crest, and legs). The stimulus set comprises 24 objects divided into four categories of six exemplars each (the files used for 3D printing are provided as Supplementary Material).ResultsWe also assessed and demonstrated the validity of our stimulus set by conducting two separate studies of haptic and visual categorization, involving participants of different ages: young adults (Study 1), and children and adolescents (Study 2). Results showed that humans can categorize our 3D complex shapes on the basis of both haptically and visually perceived similarities in shape attributes.ConclusionWidgets are very useful new experimental stimuli for categorization studies using 3D printing technology.     

Sex-specific variation in facial masculinity/femininity associated with autistic traits in the general population

Reports linking prenatal testosterone exposure to autistic traits and to a masculinized face structure have motivated research investigating whether autism is associated with facial masculinization. This association has been reported with greater consistency for females than for males, in studies comparing groups with high and low levels of autistic traits. In the present study, we conducted two experiments to examine facial masculinity/femininity in 151 neurotypical adults selected for either low, mid-range, or high levels of autistic traits. In the first experiment, their three-dimensional facial photographs were subjectively rated by 41 raters for masculinity/femininity and were objectively analysed. In the second experiment, we generated 6-face composite images, which were rated by another 36 raters. Across both experiments, findings were consistent for ratings of photographs and composite images. For females, a linear relationship was observed where femininity ratings decreased as a function of higher levels of autistic traits. For males, we found a U-shaped function where males with mid-range levels of traits were rated lowest on masculinity. Objective facial analyses revealed that higher levels of autistic traits were associated with less feminine facial structures in females and less masculine structures in males. These results suggest sex-specific relationships between autistic traits and facial masculinity/femininity.     

3～9岁儿童同情心与儿童气质类型的关系研究

该研究采用问卷调查法,探索3～9岁儿童同情心与儿童气质类型的关系,研究表明不同气质类型儿童的同情心水平存在显著差异。     

Recognition of a 3D snake model and its 2D photographic image by captive black tufted-ear marmosets (Callithrix penicillata)

Two-dimensional (2D) displays of real three-dimensional (3D) objects are frequently used experimental tools in animal studies. Whether marmoset monkeys, with their highly diverse and complex anti-predation strategies, readily recognized 2D representations of potential threats has yet to be determined, as seen in other primates. Thus, the behavioral responses of adult captive black tufted-ear marmosets (Callithrix penicillata) toward an unfamiliar motionless snake-model and its photograph were assessed. Pictorially naïve subjects were randomly divided into two groups (n = 12/each) and submitted to two trials. Group 1 was initially exposed to the 3D object and after 1 week to its photograph. Group 2 was first presented the picture and only tested with the real object 1 week later. All 15-min trials were divided into three consecutive 5-min intervals: pre-exposure, exposure and post-exposure. In the presence of the 3D snake object, regardless of its presentation order, the frequency of direct gazes, head-cocks, tsik-tsik alarm/mobbing calls and genital displays increased significantly. The photograph induced a similar response, although only when the object had been previously presented, as significantly higher levels of these behaviors were seen in Group 1 than Group 2. Proximity to the stimulus, aerial scan, terrestrial glance, displacement activities and locomotion were not consistently influenced by the stimuli’s presence and/or order of presentation. Therefore, marmosets recognized and responded appropriately to biologically and emotionally relevant 3D and 2D stimuli. Since the aversive/fearful reactions toward the photograph were only seen after the snake object had been presented, the former seems to be essentially a learned response.     

The trajectory of mathematics skills and working memory thresholds in girls with fragile X syndrome

Fragile X syndrome is a common genetic disorder associated with executive function deficits and poor mathematics achievement. In the present study, we examined changes in math performance during the elementary and middle school years in girls with fragile X syndrome, changes in the working memory loads under which children could complete a cognitive switching task, and the association between these two areas of function, in girls with fragile X syndrome relative to their peers. Our findings indicate that the trajectory of math and executive function skills of girls with fragile X differs from that of their peers and that these skills contribute to predicting math achievement and growth in math performance over time. Also, changes in math performance were associated with incremental increases in working memory demands, suggesting that girls with fragile X have a lower threshold for being able to perform under increasing task demands. Still, we found improvement in executive function performance between 10 and 12 years in girls with fragile X rather than a performance plateau as has been reported in other studies. The findings implicate the importance of early intervention in mathematics for girls with fragile X that addresses poor calculation skills, the supporting numerical skills, and deficits in executive functions, including working memory.     

Integration of weight and distance information in young children: The role of relational complexity

Young children's integration of weight and distance information was examined using a new methodology that combines a single-armed apparatus with functional measurement. Weight and distance values were varied factorially across the item set. Children estimated how far the beam would tilt when different numbers of weights were placed at different distances from the pivot. There was a developmental progression from non-systematic responding (3-year-olds) to responding based on a single variable, usually weight (4-year-olds) to responding based on integration of weight and distance (5-, 6- and 7-year-olds). Individual analyses revealed additive and multiplicative integration rules in children aged from 5 years. Weight–distance strategy complexity increased with age and was associated with better performance on independent measures of relational processing, especially the more complex items. Thus weight–distance integration involves processing of complex relational information. The findings enhance the explanatory power of Relational Complexity theory as a domain-general approach to cognitive development.