Does experienced pain affects local brain volumes? Insights from a clinical acute pain model

Background/Objective:To study pain-brain morphometry associations as a function of post-surgery stages (anesthesia, pain and analgesia) in an acute pain model. Method:Impacted mandible third molar were extracted. Before surgery, an anatomical T1 scan was obtained. Regional brain volumen and subcortical nuclei shapes were obtained. Statistical analyses were done using multiple regression, being pain scores the predictors and voxel volumes, subcortical nuclei volumes and subcortical nuclei shapes, the outcomes. Results:Pain was significantly larger at pain than at anesthesia and analgesia stages, and was higher during anesthesia than during analgesia. Pain intensity was related to grey matter in several cortical (Insula, Mid Frontal and Temporal Gyruses, Precuneus, Anterior Cingulate), and subcortical nuclei (Hippocampus, Thalamus, Putamen, Amygdala), depending of the post-surgical stage. A larger number of brain areas showed significance at pain that at anesthesia and analgesia stages. Conclusions:The relationships of regional brain volumes and subcortical nuclei shapes with pain scores seemed to be unsteady, as they changed with the patient's actual pain stage.     

Variations in patterns of lateral asymmetry among dextrals

Evidence supporting individual variations in patterns of hemispheric involvement in the recognition of visuo-spatial and verbal stimuli among dextrals is reported. In Experiment 1, subjects' asymmetry scores on a task that was nonlateralized for the group as a whole were significantly correlated with their asymmetry scores on right-hemisphere-specialized tasks, including face recognition. In Experiment 2, subjects' asymmetry scores on a task that was nonlateralized for the group as a whole were significantly correlated with their asymmetry scores on a left-hemisphere-specialized word recognition task. These results suggest that individual dextrals' asymmetry scores on lateralized tasks are a joint function of a subject's underlying hemispheric specialization for that task and stable individual variations in asymmetric hemispheric reliance.     

Hemiretinal differences in face recognition: accuracy versus reaction time

A face-recognition task involving monocular presentation of laterally displaced stimuli yielded a nasal hemiretinal advantage for reaction time for correct identifications, but a temporal hemiretinal advantage for accuracy (d'). These hemiretinal effects, in conjunction with eye dominance, could in principle distort or obscure interpretations of hemispheric processing differences obtained with binocular stimulation.     

Defining Muslims on the Afghan Frontier: T. P. Hughes and His Dictionary of Islam

ABSTRACT

Christian missionaries working in India in the nineteenth century made numerous important contributions to European and North American understandings of Islam. One such contribution was the Dictionary of Islam compiled by the Anglican missionary Thomas Patrick Hughes, who was serving in Peshawar on the border between British India and Afghanistan. Drawing upon sources such as collections of Hadith, he provided both brief definitions and some longer analyses of a wide range of aspects of Muslim beliefs, practices and history. However, his compilation was not entirely based on textual sources, but was also informed by daily contact with Muslims in and around Peshawar, particularly Maulavi Ahmad of Tangi. Hughes combined his interest in defining Islam with a passion for exploring and explaining Afghan culture and politics to his readership in Britain. Although situated on ‘the edges of empire’, Hughes nonetheless found himself at the centre of world events as the intrigue between Britain and Russia resulted in the Second Anglo-Afghan War. Although located in what some considered a minor province on the periphery of the Muslim world, he nonetheless produced a major reference work on Islam that is still in print.