NF-κB圈套寡脱氧核苷酸联合紫杉醇对肺癌细胞增殖凋亡的影响

探讨NF-κB圈套寡脱氧核苷酸(NF-κB decoy ODN)联合紫杉醇对肺癌细胞增殖凋亡的影响。培养人肺癌细胞A549:(1)脂质体瞬时转染细胞;(2)MTT试验观察细胞生长曲线;(3)流式细胞术检测细胞凋亡率。NF-κB decoyODN使细胞生长受到抑制,NF-κBdecoy ODN联合紫杉醇使细胞凋亡增加。NF-κB decoy ODN联合紫杉醇可增强对肺癌细胞增殖的抑制及凋亡的诱导。     

Durable partial reinforcement effects and social dominance in the rat

Following partial reinforcement (PRF) or consistent reinforcement (CRF) of an approach response in a straight runway and experimental extinction, rats were given the arena food-dominance test in Experiment 1 and both the arena test and the tunnel-dominance test in Experiment 2. PRF subjects were dominant in the tunnel test, but subordinate in the arena test, regardless of which dominance test was given first. These durable and pervasive effects of partial reinforcement training can be interpreted in terms of frustration theory.     

Dextroamphetamine and measures of intelligence

A sample of 320 male high school students was drawn on the basis of their neuroticism and extraversion scores from a population of 2500 students. By following a 4 × 4 randomized block design (replicated 20 times) an attempt was made to study the effects of dextroamphetamine on the test scores of fluid and crystallized intelligence of high school children. The study lends support to the hypothesis that the drug will have a differetial effect on the test scores of fluid and crystallized intelligence.     

Effects of imaginal exposure to feared disasters in obsessive-compulsive checkers

The combined effects of imaginal exposure to feared catastrophes and in vivo exposure to external stimuli were compared with the effects of in vivo exposure alone in 15 obsessive-compulsives with checking rituals. The first group received 90 min of uninterrupted exposure in imagination, which concentrated mainly on disastrous consequences, followed by 30 min of exposure in vivo to stimuli-situations which triggered rituals. The second group was given 2 hr of exposure in vivo only. Both groups were prevented from performing rituals. Treatment consisted of 10 daily sessions within a 2 week period.Assessments were conducted before and after treatment and at follow-up ranging from 3 months to 2.5 yr with a mean of 11 months. At post-treatment both groups improved considerably and did not differ. But at follow-up those who received imaginal and in vivo exposure maintained their gains, whereas the group who were treated by exposure in vivo alone evidenced partial relapse on four of the six dependent measures. The results tend to indicate that a closer match between a patient's internal fear model and the content of exposure enhances long term treatment efficacy.     

The Cultural Turn: Empirical Studies and their Implications

This essay uses empirical studies to engage Richard Miller’s advocacy of a “cultural turn” in the study of religious ethics found in Friends and Other Strangers. The particular kind of empirical research I highlight here, cultural cognition, emphasizes the ways that belonging to a cultural group influences one’s reasoning when faced with controversial issues involving disputed facts. This approach underscores the significance of the cultural turn, but it also raises some important challenges for Miller’s accounts of moral psychology and public reason. I work to elucidate what those challenges are and point to some ways that taking cultural cognition seriously might open up fresh avenues for addressing perennial ethical issues.     

Construct validation of the dependency and self-criticism scales of the depressive experiences questionnaire

S. J. Blatt (Psychoanalytic Study of the Child, 1974, 29, 107–157) distinguished between two types of depressive experiences, one characterized by strong dependency needs and the other by self-criticism and guilt. This paper reports a series of validation studies of the Depressive Experiences Questionnaire (DEQ), which was developed to measure individuals' vulnerabilities to these types of experiences (S. J. Blatt, J. P. D'Afflitti, & D. M. Quinlan, Journal of Abnormal Psychology, 1976, 85, 383–389). The Dependency and Self-Criticism scales were shown to be stable in the face of both a 13-week interval and the receipt of midterm grades. Dependency was associated with conflict concerning the expression of hostility and, in males, feelings of helplessness. Self-Criticism was associated with low self-esteem and high levels of morality-conscience guilt. In a study of behavior in dyadic problem-solving tasks, Dependency in males was found to be negatively related to task leadership, and Self-Criticism in females tended to be negatively related to judged likeability. On the other hand, little support was found for the hypotheses that Dependency would be related to field dependent cognitive style and to the use of primitive defense mechanisms. The results were viewed as supporting the utility of Blatt's distinction between the two types of depression, but a number of anomalous findings indicated a need for further study of the DEQ. The question of the developmental level of the two types of depression, possible sex differences in the correlates of the scales, and the possibility of situational specificity in individuals' responses were identified as the areas most in need of study.     

Disfluency characteristics of 2-, 4-, and 6- yr-old males

Fluency characteristics of 36 nonstuttering males aged 2, 4, and 6 yr are presented in terms of patterns of disfluency and relationships among disfluency variables. The most frequently occuring disfluency types at each age level were revision-incomplete phrase and interjections; the least noted type was part-word repetitions for 2- and 4-yr olds and disrhythmic phonations for 6-yr-olds. Patterns of disfluency appear to be similar at all age levels studied, except that the 2-yr-old pattern showed greater magnitudes in various disfluency types. A range exists in the relationships among individual disfluency types, from moderately strong relationships between, for example, revision-incomplete phrase and interjections to lack of linear relationships between, for example, interjections and phrase repetitions. A linguistic factor may be strong within certain disfluency types. e.g., revision-incomplete phrase, interjections, and word repetitions, whereas a motor factor may be operative in others, e.g., part-word repetitions and disrhythmic phonations.     

Development of strategies for recalling letter sequences

Kindergarten, second-grade, and fourth-grade children (6, 8, and 10 years of age, respectively) were asked to recall letter sequences on a task that required the use of: (a) a verbal strategy; (b) a positional strategy; or (c) either strategy. Additional trials, allowing either strategy, were interspersed among those requiring a verbal or positional strategy; strategy use was determined from performance on these interspersed trials. The results show that children at all grade levels attempted to use a task-appropriate strategy. Performance on the verbal task showed a more marked developmental increase than did performance on the positional task. A second experiment replicated the first with the interspersed trials removed. A third experiment was designed to determine whether letter names interfered with older children's efficient use of a positional strategy. Even with this source of interference removed, the developmental pattern of Experiments 1 and 2 was replicated. There was a Sex by Condition interaction in Experiments 2 and 3 which showed that males do better in the condition requiring a positional strategy, and females do better in the condition requiring a verbal strategy.     

Habituation of subjective anxiety during flooding in imagery

Patterns of habituation of subjective anxiety during flooding in fantasy are delineated for eleven obsessive-compulsive and six agoraphobic patients. The majority showed a curvilinear pattern of subjective anxiety response, while three patients showed a linear decelerating pattern. Habituation was found both within and across sessions. The results are compared with habituation patterns in physiological responses during flooding in fantasy and in vivo.