慢性乙型肝炎治疗目标及策略解析

慢性乙型肝炎治疗的目标是最大限度地长期持续抑制或清除乙肝病毒,减轻肝细胞炎症坏死及其所致的肝纤维化,延缓疾病进展,减少肝硬化、原发性肝细胞癌及其并发症的发生。治疗措施包括核苷类似物抗病毒治疗;干扰素抗病毒治疗;免疫调节治疗;抗炎治疗和抗纤维化治疗,其中抗病毒治疗是关键。     

Interpersonal problem solving as a mediator of behavioral adjustment in preschool and kindergarten children

An experimental model tested the mediating function of interpersonal cognitive problem solving skills on behavioral adjustment in preschool and kindergarten children. Relative to controls, nursery-trained youngsters improved in three such skills, kindergarten-trained in two. In both the nursery- and kindergarten-trained groups, increased ability to conceptualize alternative solutions to interpersonal problems significantly related to improved social adjustment. Consequential thinking also emerged as a clear behavioral mediator, especially among kindergarten-aged youngsters. Improvement in behavior could not, however, be attributed to change in causal thinking skills. Having identified two significant behavioral mediators in young children, a beginning has been made to isolate specific thinking skills, which, if enhanced, can contribute to healthy social adjustment and interpersonal competence at an early age.     

Looking where you listen: visual cues and auditory attention

In the non-laboratory environment, we are generally able to see the source of the sounds to which we are attending. In a preliminary examination of how and to what degree we might use this visual information, subjects shadowed one of two female voices when able to see the persons speaking (Experiment I) or when able to see, and thus precisely localize, the auditory loudspeakers (Experiment II). Selective performance was improved by being able to see the lip movements of the people whose voices were heard, and by being able to localize visually the sources of the voices.     

GENTILES AND HOMOSEXUALS: A Brief History of an Analogy

This paper examines the argument that moral approval of homosexuality is analogous to the early church's inclusion of gentiles. The analogy has a long but often overlooked history, dating back to the start of the modern gay‐rights movement. It has recently gained greater prominence because of its importance to the Episcopal Church's debate with the wider Anglican Communion. Beginning with the Episcopal Church argument, we see that there are five specific areas most in need of further clarification. In this essay I examine significant uses of the analogy from the prior 25 years to see how effectively they address these five areas. I conclude that the conversation surrounding the Gentile Analogy is the current, best hope for mutual understanding among Christians about homosexuality. However, if the analogy is to advance the Christian conversation, much greater care and precision is needed in its application from traditionalists and revisionists alike.     

MEASURING REFLECTIVE SUPERVISION WITHIN HOME VISITING: CHANGES IN SUPERVISORS’ SELF‐PERCEPTION OVER TIME

Despite widespread belief in the early childhood field of the benefits of reflective supervision, there has been limited empirical evidence to support the effectiveness of reflective supervision for home visitors and the children and families they serve. The present study examined the psychometric properties of four adapted self‐report measures assessing supervisors’ reflective supervision capacities; the study also investigated whether these measures captured change in reflective capacity over time as supervisors participated in professional development activities focused on reflective supervision. Results from 33 participants (home visiting supervisors and program managers) suggested that three of the four measures demonstrated acceptable internal consistency, and these three measures were correlated with each other. Two of these measures also captured significant change over time. Finally, there was some evidence that those with less education demonstrated more substantial improvement in their reflective supervision capacities than did those with an advanced degree. Findings provide initial evidence for reliable, efficient, and cost‐effective supervisor self‐report measures that could be used in research and program evaluation to assess change in supervisor reflective capacity over time.     

Images of the disciplining of psychology, 1890–1940

Over the course of psychology’s first several decades, the language used to convey the subject matter gradually shifted from being free and literary to being strictly constrained and disciplined by increasingly focused theoretical demands. The project described here, “Disciplining Psychology,” aimed to depict this transformation by generating images of the faces of three highly influential psychologists—William James, Sigmund Freud, and B. F. Skinner. Each image is composed of the words used in one of each individual’s most important books. The tightening of the disciplinary vocabulary is revealed in the differences among the three arrays of words themselves, but I have also striven to reflect it in the aesthetic aspects of each image. The method used here could easily be extended to a wider array of authors, texts, and psychological topics.     

慢性乙型肝炎T细胞功能与HBV前C区变异的研究

通过研究慢性HBV感染者前C区变异及T细胞免疫功能与疾病的相关性,评估前C（preC）区变异及T细胞免疫功能对于慢性乙型肝炎（chronichepatitisB,CHB）预后的影响。分别采用实时荧光法、突变特异PCRmsPCR法及微粒酶免疫分析法对150例HBV-DNA阳性的CHB及50例健康体检者进行血清HBV-DN...     

儿童慢性乙型肝炎的抗病毒治疗

儿童慢性乙型肝炎的治疗比较复杂,应正确选择抗病毒治疗的时机,合理应用有限的治疗药物。处于免疫耐受期的患儿不应治疗,处于免疫清除期或肝脏组织学提示有明显炎症的应进行治疗。干扰素是治疗的一线药物,核苷（酸）类似物是二线用药。     

Constraints on Pavlovian conditioning of the pigeon: Relative conditioned reinforcing effects of red-light and tone CSs paired with food

Recent Pavlovian conditioning experiments presented all possible CS-US combinations of red-light and tone CSs and food and shock USs to separate groups of pigeons. Pigeons receiving shock USs demonstrated conditioned head raising followed by prancing to both CSs, but CRs were acquired more rapidly to tone than to red light. Although pigeons receiving food USs rapidly acquired a conditioned response of pecking to the red-light CS, there was no evidence of conditioned responding in groups receiving tone-food pairings. This outcome left open the possibility that Pavlovian pairings of tone and food may have resulted in association formation that was not revealed in performance. The present series of experiments attempted to reveal that association, using an indirect method of assessment, conditioned reinforcement. Experiment 1 demonstrated that both red light and tone paired with food became positive conditioned reinforcers, suggesting that an association between tone and food was formed in the same number of Pavlovian conditioning trials that previously failed to yield any direct evidence of conditioning. Experiment 2, which presented fewer conditioning trials, revealed that the tone-food association was formed less rapidly than the red light-food association. Experiment 3 demonstrated that the observed outcomes were not attributable to unconditioned, rather than conditioned, reinforcing effects of the Css.