关于胚胎干细胞研究的一场伦理之争

关于“人兔细胞融合”的伦理之争,主要围绕“人兔细胞融合”实验是否违背伦理,要不要经过知情同意,以及科学技术与伦理道德的关系等问题而进行。这场讨论是正常的,健康的,有益的,倘能加以认真总结,将有助于推进学术争鸣。     

Age changes in the missing-letter effect revisited

When participants search for a target letter while reading, they make more omissions if the target letter is embedded in frequent function words than in less frequent content words. Reflecting developmental changes in component language and literacy skills, the size of this effect increases with age. With adults, the missing-letter effect is due to both word function and word frequency. With children, it is unclear whether the growing size of the missing-letter effect across development is due to a larger effect of word function, word frequency, or both because previous studies with children seeking to isolate the influence of word frequency and word function suffer from important methodological limitations. With these methodological limitations eliminated (Experiments 1 and 2), performance in a letter detection task was assessed for children in Grades 1, 2, 3, 4, and 7 as well as for undergraduate students. The results revealed that the influence of word function increases with age, whereas the effect of frequency is fairly stable across ages. Furthermore, normative predictability data collected in Experiment 3 revealed that third graders and undergraduate students were equally good at predicting function slots in a sentence.     

Psychometric Modeling of response speed and accuracy with mixed and conditional regression

Human performance in cognitive testing and experimental psychology is expressed in terms of response speed and accuracy. Data analysis is often limited to either speed or accuracy, and/or to crude summary measures like mean response time (RT) or the percentage correct responses. This paper proposes the use of mixed regression for the psychometric modeling of response speed and accuracy in testing and experiments. Mixed logistic regression of response accuracy extends logistic item response theory modeling to multidimensional models with covariates and interactions. Mixed linear regression of response time extends mixed ANOVA to unbalanced designs with covariates and heterogeneity of variance. Related to mixed regression is conditional regression, which requires no normality assumption, but is limited to unidimensional models. Mixed and conditional methods are both applied to an experimental study of mental rotation. Univariate and bivariate analyzes show how within-subject correlation between response and RT can be distinguished from between-subject correlation, and how latent traits can be detected, given careful item design or content analysis. It is concluded that both response and RT must be recorded in cognitive testing, and that mixed regression is a versatile method for analyzing test data.I am grateful to Rogier Donders for putting his data at my disposal.     

On the function of weak phantasmata in perception: Phenomenological,psychological and neurological clues for the transcendental function of imagination in perception

Weak phantasmata have a decisive and specifically transcendental function in our everyday perception. This paper provides several different arguments for this claim based on evidence from both empirical psychology and phenomenology.I would like to express my gratitude to Bill McKenna for his help with the English text and his critical remarks. This paper was presented in the Cork Roundtable for Philosophy in March 2003, at University College, Cork, and I would like to thank Julia Jansen, Tony O’Connor and the other participants for their constructive critique.     

初中生家庭功能类型与其价值观形成的关系探讨

采用亲密度与适应性量表中文版（FACESⅡ-CV）和价值观自测问卷对259名绍兴市区初中生进行了调查,结果发现：（1）亲密度高、情感联系强的家庭更容易形成符合社会规范的价值观,而情感联系弱的家庭容易形成自我中心的价值观;（2）适应性强、应变功能高的无规律型家庭有利于自律、内控的自我导向价值观的形成,并对从众型和冷漠型价值观的形成具有抑制作用;（3）家庭亲密度与适应性功能水平和踏实型价值观类型存在显著的正相关,适应性功能水平与功利型和冷漠型价值观类型存在显著的负相关。     

Neuropsychological functioning in kleptomania

Kleptomania is characterized by the failure to resist impulses to steal objects not needed for personal use or their monetary value. The objective of this study was to examine cognitive and executive functioning in subjects with kleptomania. Fifteen women with a primary DSM-IV diagnosis of kleptomania underwent a detailed psychiatric examination, including measures of kleptomania severity, and a battery of neuropsychological tests that emphasized executive functions. Correlational analyses were computed between measures of kleptomania severity and tests of executive functioning. Kleptomania subjects reported a mean duration of illness of 17.9 years and shoplifting a mean of 1.7 times per week. All subjects reported an inability to resist urges to shoplift. Neuropsychological testing revealed group mean test scores within 0.5 standard deviations of normative standards for age. Five subjects (33.3%), however, had below-average performance on at least one measure of executive functioning, and 4 (26.7%) had below-average scores on two executive measures. Correlational analyses revealed a statistically significant correlation between kleptomania severity and Wisconsin Card Sorting Test performance (r=-0.693, p=0.004). As a group, subjects with kleptomania did not demonstrate deficits on neuropsychological testing. Greater kleptomania symptom severity, however, was correlated with impairment in executive functioning.     

Parenting,corpus callosum,and executive function in preschool children

In this longitudinal population-based study (N?=?544), we investigated whether early parenting and corpus callosum length predict child executive function abilities at 4 years of age. The length of the corpus callosum in infancy was measured using postnatal cranial ultrasounds at 6 weeks of age. At 3 years, two aspects of parenting were observed: maternal sensitivity during a teaching task and maternal discipline style during a discipline task. Parents rated executive function problems at 4 years of age in five domains of inhibition, shifting, emotional control, working memory, and planning/organizing, using the Behavior Rating Inventory of Executive Function-Preschool Version. Maternal sensitivity predicted less executive function problems at preschool age. A significant interaction was found between corpus callosum length in infancy and maternal use of positive discipline to determine child inhibition problems: The association between a relatively shorter corpus callosum in infancy and child inhibition problems was reduced in children who experienced more positive discipline. Our results point to the buffering potential of positive parenting for children with biological vulnerability.     

The pathological left-handedness syndrome

A clinical syndrome of pathological left-handedness (PLH) is proposed to identify the pattern of correlative changes in lateral development associated with early brain injury in some manifest left-handers. This syndrome is believed to be caused by a hemispheric lesion that is predominantly left-sided (or bilateral asymmetric), which onsets before Age 6, and which encroaches upon the critical speech zones of the frontotemporal/frontoparietal cortex. The pattern of changes may include any or all of the following features: shifts in manual dominance, trophic changes in the extremities, transfer of hemispheric speech, and/or intrahemispheric reorganization of visuospatial cognitive functions. Although some of these correlates of PLH have long been known, they have not been recognized as an interrelated pattern of traits that constitute a clinical syndrome. Identification of these individuals, all manifest left-handers, will be shown to have implications for diagnosis/remediation and for models of recovery of function.     

Realism,instrumentalism, and the intentional stance

One of Dennett's principal arguments for an instrumentalistic construal of intentional attributions (e.g., attributions of belief, etc.) is that such attributions are environment relative. I argue that one can and should adopt a realist perspective toward such attributions, but accommodate their environmental relativity by treating intentional properties as relational properties. By doing so one acquires a useful perspective on experimental cognitive psychology; in particular, one can overcome the temptation to treat ecological accounts and information processing accounts as incompatible alternatives and come to see them as mutually supportive. Treating intentional properties as relational may be counter-intuitive, but I provide examples of how other sciences have had to treat what seem to be intrinsic properties as relational.