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孟庆义 《医学与哲学(人文社会医学版)》2007,28(4):47-48
肾上腺素是临床上心肺复苏的一线药物,但在最近二十几年以来,其剂量应用方案几经变迁,从20世纪80年代的小剂量,到90年代大剂量方案的兴起,又经历了个体化方案阶段,近几年又重新回归到小剂量给药方案。从唯物辩证法的基本思想出发,阐述心肺复苏时肾上腺素剂量变迁的哲学基础,并运用辩证唯物主义原理来探讨肾上腺素剂量研究的发展方向,这将有助于心肺复苏研究的理论与实践。 相似文献
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Rafael Roesler Mnica R. M. Vianna Fernanda de-Paris Joo Quevedo 《Neurobiology of learning and memory》1999,72(3):252-258
The aim of the present research was to verify whether the impairment of retention induced by the N-methyl-d-aspartate (NMDA) receptor blocker (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cycloheptene-5,10 imine (MK-801) can be reversed by memory-enhancing treatments. Adult female Wistar rats were trained and tested in a step-down inhibitory avoidance task (0.3-mA foot shock, 24-h training-test interval). Animals were given an ip injection of saline (SAL) or MK-801 (0.0625 mg/kg) 30 minutes before training, and an ip injection of SAL, epinephrine (EPI) (25 microg/kg), the opioid receptor antagonist naloxone (NAL) (0.4 mg/kg), the glucocorticoid receptor agonist dexamethasone (DEX) (0.3 mg/kg), or glucose (GLU) (320 mg/kg) immediately after training. There was an impairment of inhibitory avoidance retention in the MK-801-SAL, MK-801-EPI, MK-801-NAL, MK-801-DEX, and MK-801-GLU groups. There was an enhancement of retention in the SAL-EPI, SAL-NAL, SAL-DEX, and SAL-GLU groups. A control experiment showed that the amnestic effects of MK-801 could not be attributed to decreased reactivity to the foot shock. The results suggest that memory-enhancing treatments directed at modulatory mechanisms do not reverse the memory impairment induced by NMDA receptor blockade. 相似文献
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Emotional irritation before mental stress is associated with enhanced peripheral norepinephrine 总被引:1,自引:0,他引:1
Weber CS Thayer JF Rudat M Perschel FH Buchholz K Deter HC 《Scandinavian journal of psychology》2007,48(6):459-466
Research suggests equivocal findings on associations of catecholamines and mood. Our study investigated the associations of emotional state, blood pressure and catecholamines in 55 healthy males undergoing mental stress. We especially checked the reported link between norepinephrine (NE) and emotional irritation. Blood pressure (SBP, DBP) and heart rate (HR) were continuously monitored. NE and epinephrine (EPI) were measured before, after, and 20 minutes after stress. Participants were divided into irritated versus non-irritated and anxious versus non-anxious subjects by median split on their baseline questionnaires. The task elicited significant cardiovascular, hormonal, and psychological stress responses. NE levels were significantly correlated with irritation before stress. Irritated subjects showed significantly higher DBP and NE than non-irritated subjects. The higher NE and DBP levels in the irritated participants suggest detrimental psycho-physiological interrelations promoting the development of stress-mediated cardiovascular diseases. Heightened emotional irritation before stress may be regarded as a psychological risk factor. 相似文献
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