The enhancement of retention induced by vasopressin in mice may be mediated by an activation of central nicotinic cholinergic mechanisms.

Immediate post-training subcutaneous administration of lysine vasopressin (LVP, 0.003-1.00 microgram/kg) enhanced retention, whereas the vasopressin antagonist AAVP (0.01-0.30 microgram/kg) impaired it, in male Swiss mice tested 48 h after training in an inhibitory avoidance task. Both effects were dose-dependent. Neither LVP nor AAVP affected response latencies in mice not given the footshock on the training trial. The simultaneous administration of AAVP at a dose (0.01 microgram/kg) which had no effect on retention shifted the dose-response curve of LVP to the right. Nicotine (1.0-30.0 micrograms/kg, sc), a central nicotinic cholinergic agonist, also facilitated retention in a dose-related manner without affecting the retention performance of unshocked mice. The effect of nicotine was prevented by the central acting nicotinic cholinergic receptor antagonist mecamylamine (5 mg/kg, sc.). In contrast, neither hexamethonium (5 mg/kg, sc), a peripheral acting nicotinic receptor blocker, nor atropine (0.5 mg/kg, sc) or methylatropine (0.5 mg/kg, sc), two anticholinergic drugs which are known to act on muscarinic cholinergic receptors, prevented the effect of post-training nicotine. The effects of LVP and nicotine were time-dependent, suggesting that both treatments enhanced retention by influencing post-training processes involved in memory storage. Low doses of nicotine (1.50 microgram/kg, sc) or the central anticholinesterase physostigmine (35 micrograms/kg, sc) and LVP (0.003 microgram/kg, sc), which had no effect on retention when administered alone, produced a synergistic interaction when given together following training. The influence of LVP (0.03 microgram/kg, sc) on retention was prevented not only by AAVP (0.01 microgram/kg, sc) but also by mecamylamine (5 mg/kg, sc), whereas the effects of nicotine (10.0 micrograms/kg, sc) were prevented only by mecamylamine. These results suggest that the enhancement of retention induced by vasopressin is probably due to an activation of central nicotinic cholinergic mechanisms which are critical for memory formation.     

A note on partitioned determinants

A formula for the determinant of a partitioned matrix, possibly with singular submatrices, is derived and applied to some psychometric and numerical problems.     

Generalized eigenvalue problems with positive semi-definite matrices

In a recent paper in this journal McDonald, Torii, and Nishisato show that generalized eigenvalue problems in which both matrices are singular can sometimes be solved by reducing them to similar problems of smaller order. In this paper a more extensive analysis of such problems is used to sharpen and clarify the results of McDonald, Torii, and Nishisato. Possible extensions are also indicated. The relevant mathematical literature is reviewed briefly.     

Associative facilitation of word recognition as measured from a neutral prime

It is shown that lexical decision times to strong associates with an associative strength of approximately 40% are facilitated relative to targets following a neutral prime, “blank,” whereas very weak associates with an associative strength of less then 3% are neither facilitated nor inhibited. It is also shown that relative to the “blank” baseline time, a row of crosses inhibits processing of the following target. The latter finding has implications for earlier studies that have used crosses as a neutral prime. In these studies, facilitation effects have been overestimated and inhibition effects have been underestimated. Neely 1976 has proposed a predict-and-match strategy according to which subjects are assumed to predict one or more targets from the prime and to match the actual target onto the predicted targets. A part of this theory is not supported by the present data. The results are discussed in terms of the two-process theory of expectancy (Posner & Snyder, 1975). They are also considered in the light of a recent theory by Becker (1980). As an alternative interpretation of part of the reported data, a coherence assumption by the subjects about all reading materials is introduced.     

Analysis of the components of disparity in Wilde's dot-row phenomenon

Summary In this study on Wilde's phenomenon (Wilde 1950) the two components of disparity, one of them processing displacement, and the other one apparent rotation, are analysed in terms of dependence on the disparity of the end-lines of the pattern (), and on the percentage of magnification (M) of one of the monocular patterns in relation to the other one. It was found that the component of disparity for displacement ' can be expressed as a linear regression equation '=–a+b.The component of disparity for rotation, expressed as a percentage of magnification effective for rotation (M) can be expressed as M=a–b₁+b₂M.It was concluded that the two components of disparity are processed through independent parallel channels, the processing of the component of disparity for displacement being the faster process, accounting for the larger part of the total disparity.     

Maximum likelihood estimation for Luce's choice model

A terminology for general choice models based on the choice axiom is given. It applies to all kinds of choice experiments, such as confusion choice experiments, paired comparisons, triadic comparisons, directional rankings, scores on binary test items, and others. Maximum likelihood estimation for such general choice models is considered. Conditions for the uniqueness of maximum likelihood estimates are given, and it is shown that the estimates can be derived by iterative proportional fitting. This offers the opportunity of a general test of the choice axiom for all kinds of choice experiments using the likelihood ratio. The estimation and testing procedure is applied to data from a form recognition experiment, reported by W. A. Wagenaar (Nederlands Tijdschrift voor de Psychologie, 1968, 23, 96–108).     

Evidence that a factor besides progesterone, prolactin, or plasma-estradiol-binding protein inhibits estrogen-induced sexual receptivity in pregnant rats.

Daily administration of estradiol benzoate stimulated significantly less lordotic behavior in rats during the second half of pregnancy than in ovariectomized females that received subcutaneous progesterone implants, pituitary grafts that raised plasma prolactin, or both treatments combined. Following an initial facilitation of receptivity, females with progesterone implants showed only moderate reductions in lordosis quotients over 3 test days. The capacity of plasma from pregnant rats to bind estradiol was found to increase significantly during the second half of pregnancy. However, daily administration to pregnant rats of a synthetic estrogen, R 2858, which is not bound by plasma protein, was no more effective than estradiol benzoate in stimulating receptive behavior. Administration of estradiol benzoate also stimulated significantly lower levels of sexual behavior in pregnant females than in females in which pseudopregnancy had been prolonged by previous hysterectomy or induction of uterine decidualization. These findings suggest that some endocrine factor other than progesterone, prolactin, or estradiol-binding protein is primarily responsible for the potent suppression of behavioral responsiveness to estrogen which occurs in pregnant rats. It is suggested that 5 alpha-reduced androgens may cause these behavioral effects.     

Demonstration of an aftereffect occurring in the tactile-kinesthetic domain

Summary The aim of this work is the demonstration of a tactile-kinesthetic aftereffect. A sequence of stimuli was offered to adult subjects whose task was to compare two weights presented simultaneously to both hands by means of a Piéron gravimeter. In Experiment 1 the inspection stimuli consisted of two successive presentations of unequal weights for a period of 2 × 10 s. The test stimuli consisted of two equal weights rapidly following an inspection stimulus. Control stimuli consisting of two equal weights not preceded by an inspection stimulus were interspersed in the sequence. The results obtained confirm the existence of a contrast effect after presentation of an inspection stimulus. In Experiment 2 the inspection stimuli consisted of a single presentation of two unequal weights for a period of 20 s. The results confirm those of the first experiment and provide data enabling the contrast effect obtained to be interpreted as a Köhler-type aftereffect. In order to avoid confusion with the kinesthetic-figural aftereffect, we propose to call the effect demonstrated here the Gravimetric Aftereffect.     

Correctness of Kruskal's algorithms for monotone regression with ties

Kruskal has proposed two modifications of monotone regression that can be applied if there are ties in nonmetric scaling data. In this note we prove Kruskal's conjecture that his algorithms give the optimal least squares solution of these modified monotone regression problems. We also propose another (third) approach for dealing with ties.Comments by Dr. J. B. Kruskal have been most helpful.