Benzodiazepine receptor ligand influences on acquisition: suggestion of an endogenous modulatory mechanism mediated by benzodiazepine receptors

In rats, pretraining ip administration of the central benzodiazepine receptor antagonist, flumazenil (5.0 mg/kg), or of the inverse agonist, n-butyl-beta-carboline-3-carboxylate (BCCB) (0.2 or 0.5 mg/kg), facilitated retention of a step-down inhibitory avoidance task; the central agonists, clonazepam and diazepam (0.4 or 1.0 mg/kg), had an opposite effect, and the peripheral agonist, 4'-chlordiazepam (1.25 or 6.25 mg/kg), was without effect. Pre- but not post-training flumazenil (2.0 mg/kg) blocked the effect of BCCB (0.5 mg/kg), clonazepam (1.0 mg/kg), or diazepam (1.0 mg/kg) given also pretraining. The post-training administration of all of these drugs had no effect on retention of the avoidance task. Flumazenil (5.0 mg/kg) and BCCB (0.5 mg/kg), given before training, enhanced retention test performance of habituation to a buzzer but not of habituation to an open field. In the three tasks studied, none of the drugs used had any appreciable effect on training session parameters. These results suggest that there is an endogenous mechanism mediated by benzodiazepine agonists, sensitive to inverse agonists, that normally down-regulates acquisition of certain behaviors; this mechanism becomes activated only when the tasks involve or occur with a certain degree of stress or anxiety (i.e., inhibitory avoidance or habituation to the buzzer) and not in less stressful or anxiogenic tasks (i.e., habituation to an open field).     

Time courses in visual-information processing: Some theoretical considerations

Summary In the literature two different views with regard to the time course of activation of recognition units —hypothetical entities that represent identity information —are proposed. Both views are derived from a restricted set of phenomena in visual perception. The first view gets its intuitions from phenomena such as those summarized by Bloch's law; these phenomena show integration or summation of activation over time. This grow-and-grow view assumes that recognition units accumulate activation gradually over times The second view finds its inspiration in phenomena such as Mach-bands and simultaneous contrast; these phenomena show inhibition or steady-state suppression over time. This grow-and-shrink view assumes that the activation levels increase fast initially and then start to decrease.The perception literature strongly suggests that it may be light intensity that determines whether mainly integration (and phenomena such as Bloch's law) or inhibition (and phenomena such as Mach-bands) is obtained. So it is also likely that both information-processing views apply only to a limited range of intensity conditions; the grow-and-grow view to conditions of low-flight intensities, and the grow-and-shrink view to conditions of intermediate-and high-light intensities.It is argued that, to arrive at a complete view, a visual phenomenon that applies to the complete range of light intensities should be taken as a background for generating hypotheses about time courses in visual-information processing. The Broca-Sulzer effect is such a phenomenon. Starting from this phenomenon a simple, synthesizing, information-processing model is derived that is compatible with both the grow-and-grow view and the grow-andshrink view. It is shown that, besides the relevant temporal properties, this model also produces the appropriate spatial properties.     

Indeterminacy of the isomorphism heuristic

Summary We are less prone today than in Köhler's time to believe in a unified science. The Gestalt program could therefore safely abandon the psychophysical isomorphism heuristic if it wished to. Indeterminacy of the heuristic might be a reason for doing so. The determination of the components involved in the isomorphism of the visual field as well as the electrocortical events would have to occur simultaneously. In the Gestalt program, however, components are determined by their position in the whole. They can therefore not be compared in different contexts, so no independent test of a candidate heuristic is possible.     

Sex role flexibility and prosocial behavior among preschool children

The relationship between sex role flexibility and prosocial behavior among preschool children was investigated. Subjects included 16 boys and 18 girls, ranging in age from 36 to 60 months, from intact families of the upper middle class. A nonhierarchical multiple regression analysis was undertaken to determine the contributions of the predictor variables of sex, age, IQ, and sex role flexibility, as well as their interactions with prosocial behavior (criterion variable). Results indicated that while the overall regression model was not significant, the variable of Sex × Sex Role Flexibility did contribute significantly to the model. Inspection of the correlation coefficients associated with this variable revealed that while sex role flexibility and prosocial behavior among boys were significantly and positively related, among girls no significant relationship was found.     

Contributions of the care-giving role to women's development

It was hypothesized that older widows (N=309) who had been care givers to their husbands would have undertaken a greater number of household responsibilities than had women who had not been care givers. Findings indicated that, prior to the husband's death, more traditionally male and more traditionally female tasks were performed by the care-giving wives (n=158). This was particularly true in the case of Alzheimer's care givers (n=21). More importantly, widows' present feelings of competence were related to undertaking household responsibilities, with those who had been care givers expressing significantly higher levels of competence.     

The Antinomies of Collective Political Trauma: A Pre-Theory

Prime Minister Yitzhak Rabin's assassination has less of a lasting impact on the Israeli public's political values, beliefs and attitudes than might have been anticipated from the magnitude of the event and intensity of the immediate responses. Why did the assassination have such a short-lived effect? This article considers the puzzle as a specific case of the broader phenomenon of collective political trauma and its consequences for values, beliefs and attitudes held by the mass public toward issues that it associates with the traumatic event. The article offers six deductively inferred hypotheses that describe, explain and link affective, cognitive and behavioral aspects of collectively experienced trauma. These hypotheses form a pre-theory explaining the perseverence of core political cognitions, even in the face of a considerable challenge to their validity and relevance.