Kv4 potassium channels modulate hippocampal EPSP-spike potentiation and spatial memory in rats

Kv4 channels regulate the backpropagation of action potentials (b-AP) and have been implicated in the modulation of long-term potentiation (LTP). Here we showed that blockade of Kv4 channels by the scorpion toxin AmmTX3 impaired reference memory in a radial maze task. In vivo, AmmTX3 intracerebroventricular (i.c.v.) infusion increased and stabilized the EPSP-spike (E-S) component of LTP in the dentate gyrus (DG), with no effect on basal transmission or short-term plasticity. This increase in E-S potentiation duration could result from the combination of an increase in excitability of DG granular cells with a reduction of GABAergic inhibition, leading to a strong reduction of input specificity. Radioactive in situ hybridization (ISH) was used to evaluate the amounts of Kv4.2 and Kv4.3 mRNA in brain structures at different stages of a spatial learning task in naive, pseudoconditioned, and conditioned rats. Significant differences in Kv4.2 and Kv4.3 mRNA levels were observed between conditioned and pseudoconditioned rats. Kv4.2 and Kv4.3 mRNA levels were transiently up-regulated in the striatum, nucleus accumbens, retrosplenial, and cingulate cortices during early stages of learning, suggesting an involvement in the switch from egocentric to allocentric strategies. Spatial learning performance was positively correlated with the levels of Kv4.2 and Kv4.3 mRNAs in several of these brain structures. Altogether our findings suggest that Kv4 channels could increase the signal-to-noise ratio during information acquisition, thereby allowing a better encoding of the memory trace.     

Remodeling of the neuronal circuits underlying opiate-withdrawal memories following remote retrieval

Several types of memory display time-dependent reorganization of their underlying neural substrates, but it remains unclear whether affective memories associated with drug effects also follow similar reorganization. Here, we analyzed the neural circuits reactivated by the re-exposure of former dependent rats to the withdrawal-paired environment 1month after conditioning (remote memory) as compared with recent memory (Frenois, F., Stinus, L., Di Blasi, F., Cador, M., & Le Moine, C. (2005) A specific limbic circuit underlies opiate withdrawal memories The Journal of Neuroscience, 25, 1366-1374). C-fos expression showed that the circuits involved in the retrieval of withdrawal memories are partly different when comparing recent and remote reactivation, showing that, like other type of memories, affective memories linked to opiate withdrawal undergo anatomical reorganization, with a shift from extended amygdala regions toward cortical areas.     

Teaching Fourth and Fifth Graders to Evaluate Information Sources During Text Comprehension

In two experiments, we examined fourth and fifth graders' comprehension of the source of information in texts presenting controversial issues. In Experiment 1, participants read short texts in which two people presented different arguments regarding an issue. Participants identified who said what and evaluated each source's knowledge of the issue. Most students correctly identified the source of information but failed to take into account each source's characteristics when determining who was most knowledgeable. In Experiment 2, we implemented an intervention on students' evaluations of information sources. Less skilled students in the intervention group assessed source knowledge more accurately than those in a control group. We conclude that elementary school students' comprehension of who says what in a text can benefit from training sessions that involve practice, feedback, explanations, and discussions. We consider the implications for document-based learning in elementary and secondary education.     

Creep behaviour of ice single crystals loaded in torsion explained by dislocation cross-slip

Torsion creep experiments are carried out in order to understand the physics of ice plasticity. A dislocation spreading mechanism based on double cross-slip of basal dislocations is proposed to explain the strong plastic anisotropy and the power law relationship between stress and strain rates. The scenario is tested using three-dimensional dislocation dynamics simulations. Numerical investigations give a stress exponent n?=?2.3 in agreement with experimental measurements. This dislocation spreading mechanism sheds a new light on the interpretation of former experimental observations.     

Modus Tollens,Modus Shmollens: Contrapositive reasoning and the pragmatics of negation

The utterance of a negative statement invites the pragmatic inference that some reason exists for the proposition it negates to be true; this pragmatic inference paves the way for the logically unexpected Modus Shmollens inference: “If p then q; not-q; therefore, p.” Experiment 1 shows that a majority of reasoners endorse Modus Shmollens from an explicit major conditional premise and a negative utterance as a minor premise: e.g., reasoners conclude that “the soup tastes like garlic” from the premises “If a soup tastes like garlic, then there is garlic in the soup; Carole tells Didier that there is no garlic in the soup they are eating.” Experiment 2 shows that this effect is mediated by the derivation of a pragmatic inference from negation. We discuss how theories of conditional reasoning can integrate such a pragmatic effect.     

Letter and Category Fluency in Normal Elderly Participants: a Population-Based Study

We studied variables influencing category and letter fluency in a large population-based sample of elderly participants. Letter and category fluency tasks were administered to 1133 unselected non-demented elderly participants in the Paquid cohort on normal and pathological aging. Age, education, principal lifetime occupation and depressive symptomatology independently influenced both category and letter fluency, while gender influenced only category fluency. A conceptualization measure (similarities) was found to influence fluency results mostly through education and prior occupation.     

Experimental philosophers,conceptual analysts,and the rest of us

Abstract

Theories of personal identity purport to specify truth conditions for sentences of the form ‘x‐at‐t_i is the same person as y‐at‐t_j. Most philosophers nowadays agree that such truth conditions are to be stated in terms of psychological continuity. However; opinions vary as to how the notion of psychological continuity is to be understood. In a recent contribution to this journal, Slors offers an account in which psychological continuity is spelled out in terms of narrative connectedness between mental states.The present paper argues that Slors’ theory either is no theory of personal identity at all or is too weak.Towards the end of the paper, it is indicated how the problem uncovered for Slors’ theory may be avoided.