Distinct and shared cognitive functions mediate event- and time-based prospective memory impairment in normal ageing

Prospective memory (PM) is the ability to remember to perform an action at a specific point in the future. Regarded as multidimensional, PM involves several cognitive functions that are known to be impaired in normal ageing. In the present study we set out to investigate the cognitive correlates of PM impairment in normal ageing. Manipulating cognitive load, we assessed event- and time-based PM, as well as several cognitive functions, including executive functions, working memory, and retrospective episodic memory, in healthy participants covering the entire adulthood. We found that normal ageing was characterised by PM decline in all conditions and that event-based PM was more sensitive to the effects of ageing than time-based PM. Whatever the conditions, PM was linked to inhibition and processing speed. However, while event-based PM was mainly mediated by binding and retrospective memory processes, time-based PM was mainly related to inhibition. The only distinction between high- and low-load PM cognitive correlates lies in an additional, but marginal, correlation between updating and the high-load PM condition. The association of distinct cognitive functions, as well as shared mechanisms with event- and time-based PM, confirm that each type of PM relies on a different set of processes.     

Age-Related Changes in Executive Function: A Normative Study with the Dutch Version of the Behavior Rating Inventory of Executive Function (BRIEF)

This study examined age-related change in executive function by using a Dutch translation of the Behavior Rating Inventory of Executive Function (BRIEF; Gioia et al., 2000 Gioia, G. A., Isquith, P. K., Guy, S. C. and Kenworthy, L. 2000. Behavior Rating Inventory of Executive Function BRIEF): Professional manual, Lutz, FL: Psychological Assessment Resources.  [Google Scholar]) that was applied to a normative sample (age range 5–18 years). In addition, we examined the reliability and factorial structures of the Dutch BRIEF. Results with respect to age revealed a decrease in reported executive function problems with increasing age. On the Behavior Regulation Index (BRI), 5- to 8-year-olds showed significantly more executive function problems than 9- to 11-year-olds, as did the 12- to 14-year-olds compared to 15- to 18-year-olds (except on the Shift subscale). On the Metacognition Index, we found that 9- to 11-year-olds differed significantly from 5- to 8-year-olds on the Working Memory subscale. In addition, the current study showed that the internal consistency of the Dutch BRIEF is very high, and that this version of the BRIEF has a high test-retest stability. Item factor analysis confirmed the expected eight common factor model, and factor analysis of the eight test scores confirmed the two-factor model, as proposed by Gioia et al., in the Dutch data.     

Irony,Deception, and Subjective Truth: Principles for Existential Teaching

This paper takes the position that the aim of existential teaching, i.e., teaching where existential questions are addressed, consists in educating the students in light of subjective truth, where the students are ‘educated’ to exist on their own, i.e., independent of the teacher. The question is whether it is possible to educate in light of existence. It is, in fact impossible, as existence is a subjective matter, meaning that it must be determined individually. In this way the existential teaching appears thus: even though existence cannot be determined educationally, as it is a subjective matter, it does require some kind of education. However, the teacher cannot make use of pedagogical means that coerce the students to take responsibility for their subjective truth. A pedagogical ‘expedient’ is nonetheless required, which deprives of all types of constraint but still opens up for the students taking responsibility for their subjective truth. I argue that this expedient must be irony, but not all types of irony. I therefore discuss which conception of irony the existential teaching should and should not be connected with.     

The why and how of goal pursuits: Effects of global autonomous motivation and perceived control on emotional well-being

This study examined the effects of global autonomous motivation and global perceived control on young adults’ adaptive goal striving and emotional well-being. We reasoned that autonomously motivated participants who also perceive high levels of control would make accelerated progress with the pursuit of their most important goal and experience associated increases in emotional well-being. By contrast, we predicted that these benefits of autonomous motivation would be reduced among participants who perceive low levels of control. A 6-month longitudinal study of 125 college students was conducted, and self-reported global autonomous motivation, global perceived control, progress towards the most important goal, and emotional well-being were assessed. Regression analyses showed that the combination of high baseline levels of global autonomous motivation and global perceived control was associated with accelerated goal progress after 6 months, which mediated 6-month increases in emotional well-being. These benefits were not apparent among autonomously motivated participants who perceived low levels of control. The study’s findings suggest that global autonomous motivation and perceived control may need to work together to foster adaptive goal striving and emotional well-being.     

The impact of magnitude of harm and perceived difficulty of making reparations on group‐based guilt and reparation towards victims of historical harm

The present research investigates how reading stories about past mistreatment of children who had been in institutional care affects support for reparations, perceived difficulty of reparations and group‐based guilt were investigated in two experiments. In Study 1 we showed that, when the stories increased in perceived harm, so did the perceived difficulty of making reparations whereas group‐based guilt decreased. Furthermore, both perceived difficulty of making reparations and group‐based guilt predicted support for reparation. It was suggested that these findings were due to a natural confound between the severity of harm and the difficulty of reparations. Study 2 included a direct manipulation of perceived difficulty that was intended to weaken or strengthen the ability to make reparations. This study demonstrated stronger group‐based guilt when reparations were potentially possible and not when they are impossible. Moreover, support for reparations varied as a function of perceived difficulty of reparations and group‐based guilt mediated that relationship. The research has two key implications. First, advocates of reparations as a mechanism for reconciliation and community healing need to consider the degree to which reparations are perceived to be possible and consider ways of addressing those perceptions. Second, the research provides an experimental demonstration to the power of stories about experience to bolster support for social change. Copyright © 2009 John Wiley & Sons, Ltd.     

Phenomenology,psychopathology, and short‐term therapeutic outcome of 102 infants aged 0 to 12 months consecutively referred to a community‐based 0 to 3 mental health clinic

Infants ages 0 to 1 year consecutively referred for psychiatric treatment during the year 2005 were followed, and variables associated with diagnosis and short‐term outcome were assessed. Infants were evaluated using the Psychiatric Infant Navigator Chart and Evaluation that includes nosological diagnoses [Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood, (DC 0–3), Zero to Three, 1994] as well as risk and protective factors, treatment procedure, and outcomes. Seventy‐six percent of the infants had an Axis I diagnosis, with anxiety disorders and a mixed disorder of emotional expressiveness being the most frequent. Twenty‐five percent had an Axis II diagnosis. Multiple correspondence analyses showed that two dimensions corresponding grossly to DC 0–3 Axes I and II emerged. They emphasized three clinical profiles characterized by (a) good infant functioning, parent's awareness of their own difficulties, and a good outcome; (b) moderate child symptoms, overinvolved relating, and a good/intermediate outcome; (c) severe child symptoms, underinvolved relating, and a less favorable short‐term outcome, signaling the risk for developmental disorders. Among the associated risk factors were cumulative parental stress, maternal psychopathology, and family dysfunction. Clinical implications of these findings indicated that infants under the age of 1 year who are referred for mental health evaluation and intervention are a heterogeneous group in terms of both severity and prognosis. Clinicians should differentiate subgroups of young children to detect those infants at risk for persistent psychopathology.     

Interacting noradrenergic and corticosteroid systems shift human brain activation patterns during encoding

Emotionally arousing experiences are usually well retained, an effect that depends on the release of adrenal stress hormones. Animal studies have shown that corticosterone and noradrenaline – representing the two main stress hormone systems – act in concert to enhance memory formation by actions involving the amygdala, hippocampus and prefrontal cortex (PFC). Here we test whether interactions between these two stress hormone systems also affect human memory formation as well as the associated pattern of brain activation. To this end, forty-eight male human subjects received hydrocortisone, yohimbine or both before presentation of emotional and neutral pictures. Activity in the amygdala, hippocampus and PFC was monitored with functional Magnetic Resonance Imaging (fMRI) during encoding of these stimuli, when hormonal levels were elevated. Memory performance was tested 1 week later. We investigated whether an increased level of one of the two hormone systems would lead to differential effects compared to the combined application of the drugs on brain activation and memory performance. We report that the application of cortisol led to an overall enhancing effect on recognition memory, with no significant additional effect of yohimbine. However, during encoding the brain switched from amygdala/hippocampus activation with either hormone alone, to a strong deactivation of prefrontal areas under the influence of the combination of both exogenous hormones. Although we did not find evidence that exogenous stimulation of the noradrenergic and corticosteroid systems led to significant interaction effects on memory performance in this experiment, we conclude that stress hormone levels during encoding did differentially determine the activation pattern of the brain circuits here involved.     

HIV‐related stigma in social interactions: Approach and avoidance behaviour in a virtual environment

People living with HIV are a stigmatized group in our society, especially homosexual people living with HIV. One of the behavioural manifestations of stigmatization is an increased interpersonal distance kept during social interactions. Immersive virtual environment technology enables the experimental study of social interactions in an accurate and relatively unobtrusive manner. Using a virtual hospital room, we measured to what extent diagnosis (HIV, cancer or broken leg) and sexual orientation (homosexual or heterosexual) were related to approach behaviour (based on the interpersonal distance and the speed of approach), and the degree patients were looked at (as was obtained from an additional exploration of our head orientation data). Moreover, implicit and explicit attitudes were predicted to moderate this relationship. Participants (N = 50) were healthy, heterosexual students. A main effect of diagnosis revealed larger interpersonal distances from patients with HIV than from patients with cancer. Also, an interaction effect demonstrated that distances were largest when the HIV patient was homosexual. Furthermore, a main effect of diagnosis showed that HIV and cancer patients were approached more slowly than broken leg patients, an effect that was larger for HIV than for cancer patients. In addition, head orientation analyses revealed that patients with HIV were relatively ‘looked at’ more often as well as relatively ‘looked away from’ less often than patients with cancer and patients with a broken leg. None of these effects however were found to be moderated by implicit and explicit attitudes. These findings provide behavioural evidence for the stigmatization of people living with HIV and homosexuals with HIV in particular. Copyright © 2015 John Wiley & Sons, Ltd.     

Risk of bias in trial-based economic evaluations: Identification of sources and bias-reducing strategies

Objective: The objectives of this article are first to give an overview of the risks of bias in trial-based economic evaluations and, second, to identify how key sources for bias can be revealed and overcome (i.e. what bias-reducing strategies might be employed) in future trial-based economic evaluations in the field of health psychology.

Design: Narrative review discussing sources of bias in trial-based economic evaluations and bias-reducing strategies.

Results: We identified 11 biases and assigned them to a particular trial phase. A distinction is made between pre-trial biases, biases during the trial and biases that are relevant after the actual trial. All potential forms of bias are discussed in detail and strategies are shown to detect and overcome these biases.

Conclusion: In order to avoid bias in trial-based economic evaluations, one has to be aware of all the possible forms of bias. All stakeholders have to examine trial-based economic evaluations in a rigorous and stringent manner. This article can be helpful in this examination as it gives an overview of the possible biases which researchers should take into account.