Gabaergic mechanisms of hypothalamic nuclei in the expression of conditioned fear

The amygdala, the dorsal periaqueductal gray (dPAG), and the medial hypothalamus have long been recognized to be a neural system responsible for the generation and elaboration of unconditioned fear in the brain. It is also well known that this neural substrate is under a tonic inhibitory control exerted by GABA mechanisms. However, whereas there is a growing body of evidence to suggest that the amygdala and dPAG are also able to integrate conditioned fear, it is still unclear, however, how the distinct hypothalamic nuclei participate in fear conditioning. In this work we aimed to examine the extent to which the gabaergic mechanisms of this brain region are involved in conditioned fear using the fear-potentiated startle (FPS). Muscimol, a GABA-A receptor agonist, and semicarbazide, an inhibitor of the GABA synthesizing enzyme glutamic acid decarboxylase (GAD), were used as an enhancer and inhibitor of the GABA mechanisms, respectively. Muscimol and semicarbazide were injected into the anterior hypothalamus (AHN), the dorsomedial part of the ventromedial nucleus (VMHDM), the dorsomedial (DMH) or the dorsal premammillary (PMD) nuclei of male Wistar rats before test sessions of the fear conditioning paradigm. The injections into the DMH and PMD did not produce any significant effects on FPS. On the other hand, muscimol injections into the AHN and VMHDM caused significant reduction in FPS. These results indicate that injections of muscimol and semicarbazide into the DMH and PMD fail to change the FPS, whereas the enhancement of the GABA transmission in the AHN and VMHDM produces a reduction of the conditioned fear responses. On the other hand, the inhibition of this transmission led to an increase of this conditioned response in the AHN. Thus, whereas DMH and PMD are known to be part of the caudal-most region of the medial hypothalamic defensive system, which integrates unconditioned fear, systems mediating conditioned fear select the AHN and VMHDM nuclei that belong to the rostral-most portion of the hypothalamic defense area. Thus, distinct subsets of neurons in the hypothalamus could mediate different aspects of the defensive responses.     

Recurrent criminal behavior and executive dysfunction

OBJECTIVE: To experimentally test the hypothesis that people who repeatedly participate in forms of non-violent crime exhibit an executive deficit detected in tests of high ecological validity, having changes in prefrontal functioning as neurophysiologic basis. PARTICIPANTS AND METHODS: A batteiy to assess executive dysfunction was administered--the Behavioural Assessment of the Dysexecutive Syndrome (BADS)--to an experimental group of 30 inmates convicted of crimes against property (mean age = 39.3, SD = 9.98), and a control group of 30 (mean age = 32.7, SD = 11.8), all male. RESULTS: The group of recurrent inmates performed significantly worse than the control group in their global scores on the battery, as well as in the majority of subscales. CONCLUSION: Without removing from consideration the fact that sample size was not very large and, primarily, alerting ourselves to the dangerous hypothesis of a "frontal criminogenesis," the authors interpret criminal recurrence and resistance to penal measures in terms of the scarcity of control that individuals from the experimental group have over their behavior and its respective consequences.     

Psychological Follow-up of Presymptomatic Genetic Testing for Spinocerebellar Ataxia Type 2 (SCA2) in Cuba

Presymptomatic testing for spinocerebellar ataxia type 2 (SCA2) in Cuba started five years ago. We have now investigated the psychological impact of test results on 150 individuals at 50% risk for SCA2. In a prospective study, psychological instruments were used to evaluate depression, anxiety and family functioning (1) before testing and (2) one year after disclosure of the test result. One year after, anxiety and depression levels decreased both in carriers and non-carriers, but anxiety decreased significantly more in carriers. Pathological levels of anxiety were seen mostly in members of dysfunctional families, but decreased more in them than in other consultands. Presymptomatic testing thus seems to have been especially beneficial for these testees, possibly due to a greater gain from the psychosocial support received. It would be pertinent to evaluate now the impact of other psychosocial variables and perform longer-term longitudinal studies.     

The impact of object size and rigidity on infant reaching

Although the changes in kinematics of infant reaching have been studied, few researchers have investigated the improvement of reaching regarding objects of distinct physical properties. The aim of this longitudinal study was to verify the impact of object size and rigidity on the development of reaching in 4-6-month-old infants. Four infants were observed with a motion capture system during trials with four objects of distinct sizes and rigidity. A total of 188 reaches were analyzed by using the 3D movement reconstruction. Our results showed that reaching frequency, mean velocity, and straightness index increased with age. The number of movement units decreased with age and increased for small objects. Rigidity was not shown to affect reaching trajectories. These findings suggest that infants are capable of perceiving the more relevant object properties, thus using their available motor capabilities to modify the essential variables so that they can reach the target more accurately.     

How capuchin monkeys (Cebus apella) quantify objects and substances

Humans and nonhuman animals appear to share a capacity for nonverbal quantity representations. But what are the limits of these abilities? Results of previous research with human infants suggest that the ontological status of an entity as an object or a substance affects infants' ability to quantify it. We ask whether the same is true for another primate species-the New World monkey Cebus apella. We tested capuchin monkeys' ability to select the greater of two quantities of either discrete objects or a nonsolid substance. Participants performed above chance with both objects (Experiment 1) and substances (Experiment 2); in both cases, the observed performance was ratio dependent. This finding suggests that capuchins quantify objects and substances similarly and do so via analog magnitude representations.     

Development of the Connectedness to Treatment Setting Scale for Children with Cancer and Their Parents

Treatment for pediatric cancer requires periodic and long hospital admissions. The intensity and frequency of the interactions taking place in the treatment setting indicate that this is a context to which children and their families can feel connected. This study’s main goal was to develop the Connectedness to Treatment Setting Scale (CTSS-Pediatric Cancer), a 10-item scale assessing children’s and parents’ connectedness to the health setting where children receive cancer treatment. Participants were 128 dyads of children receiving treatment at two Portuguese public hospitals and their parents. Two exploratory factor analyses with children’s and parents’ data separately and a dyadic confirmatory factor analysis with the whole sample supported a second-order factorial structure of the CTSS-Pediatric Cancer, where three dimensions (Sense of Belonging, Comfort and Emotional Care) loaded onto a total score of connectedness. Findings suggest that the CTSS-Pediatric Cancer is a valid and useful assessment measure.     

Dimensionality and Measurement Invariance of a Brief Form of the Young Schema Questionnaire for Adolescents

The current work aims to develop and examine the psychometric properties of the Brief form of the Young Schema Questionnaire for Adolescents (B-YSQ-A), so that Early Maladaptive Schemas can be accurately measured in younger populations. Early Maladaptive Schemas are self-defeating core themes underlying maladaptive cognition, affect, and behavior. A community sample of 877 adolescents, aged 12–18 years old, filled out self-report instruments on maladaptive schemas, anger management, and internalizing and externalizing symptoms. The items composing the B-YSQ-A were selected based on statistical and content analyses criteria. Its internal structure, reliability, age- and gender-based invariance, and between-gender mean differences were examined, as well as its relationship with external variables. Results indicated a satisfying fit for the 18 original schema factors through confirmatory factor analysis. These schemas also showed adequate internal consistency and test-retest reliability, with the exception of the entitlement/grandiosity and self-sacrifice schemas. The B-YSQ-A was found to be age and gender invariant. Concerning gender differences, boys scored higher on the entitlement/grandiosity, insufficient self-control/discipline, approval/recognition seeking, unrelenting standards/hyper-criticalness and punitiveness schemas, whereas girls scored higher on the abandonment/instability, mistrust/abuse, and self-sacrifice schemas. Furthermore, evidence was found for construct validity in relation to measures of internalizing and externalizing symptomatology and of anger expression. Findings offer support for the use of the B-YSQ-A with adolescents, both for research and intervention purposes.