Decreased Sensitivity to Phonemic Mismatch in Spoken Word Processing in Adult Developmental Dyslexia

Initial lexical activation in typical populations is a direct reflection of the goodness of fit between the presented stimulus and the intended target. In this study, lexical activation was investigated upon presentation of polysyllabic pseudowords (such as p rocodile for crocodile) for the atypical population of dyslexic adults to see to what extent mismatching phonemic information affects lexical activation in the face of overwhelming support for one specific lexical candidate. Results of an auditory lexical decision task showed that sensitivity to phonemic mismatch was less in the dyslexic population, compared to the respective control group. However, the dyslexic participants were outperformed by their controls only for word-initial mismatches. It is argued that a subtle speech decoding deficit affects lexical activation levels and makes spoken word processing less robust against distortion.     

机体蛋白质复杂性与植物药复方的统一

植物药复方是中医辨证施治的主要手段。药物是通过蛋白质起作用的。蛋白质复杂多样的功能与其时空的复杂演变密切相关,复方如何对蛋白质时空产生影响、如何对其结构与功能发生作用以及两者之间相互作用、相互影响的深入研究可能发现新的生命现象,为阐明疾病发病机理以及植物药的创新研制奠定理论基础和提供技术支持。     

Sunscreens with Titanium Dioxide (TiO<Subscript>2</Subscript>) Nano-Particles: A Societal Experiment

The risks of novel technologies, such as nano(bio)technology cannot be fully assessed due to the existing uncertainties surrounding their introduction into society. Consequently, the introduction of innovative technologies can be conceptualised as a societal experiment, which is a helpful approach to evaluate moral acceptability. This approach is illustrated with the marketing of sunscreens containing nano-sized titanium dioxide (TiO₂) particles. We argue that the marketing of this TiO₂ nanomaterial in UV protective cosmetics is ethically undesirable, since it violates four reasonable moral conditions for societal experimentation (absence of alternatives, controllability, limited informed consent, and continuing evaluation). To remedy the current way nano-sized TiO₂ containing sunscreens are utilised, we suggest five complementing actions (closing the gap, setup monitoring tools, continuing review, designing for safety, and regulative improvements) so that its marketing can become more acceptable.     

Development and validation of a questionnaire about the main variables affecting the individual investor's behavior in the Stock Exchange

Development and validation of a questionnaire about the main variables affecting the individual investor's behavior in the Stock Exchange. There is a considerable lack of information about the methodology usually used in most of the studies about individual investor's behavior. The studies reviewed do not show the method used in the selection of the items or the psychometric properties of the questionnaires. Because of the importance of investment in the Stock Exchange nowadays, it seems relevant to obtain a reliable instrument to understand individual investor's behavior in the Stock Exchange. Therefore, the goal of the present work is to validate a questionnaire about the main variables involved in individual investors' behavior in the Stock Exchange. Based on previous studies, we elaborated a questionnaire using the Delphi methodology with a group of experts. The internal consistency (Cronbach alpha=.934) and validity evidence of the questionnaire show that it may be an effective instrument and can be applied with some assurance.     

口腔颌面部鳞状细胞癌的综合序列治疗

口腔颌面部鳞状细胞癌(鳞癌)在头颈部肿瘤的发病和治疗中占有重要地位,综合序列治疗的概念和理论逐渐成为口腔颌面部鳞癌治疗的指导原则.本文对口腔颌面部鳞癌综合序列治疗所包含的手术治疗、放射治疗、化学治疗及生物治疗从临床治疗策略上进行分析、讨论,以期促进口腔颌面部鳞癌综合序列治疗原则在临床获得更好地应用.     

Simultaneously Testing Parenting and Social Cognitions in Children At-Risk for Aggressive Behavior Problems: Sex Differences and Ethnic Similarities

In this cross-sectional study we examined a model in which parenting, child social information processing and self-perception are simultaneously tested as risk factors associated with aggression. Sex and ethnicity were tested as moderators of associations. The sample consisted of 206 4th grade children in the Netherlands. Parents reported on parenting, parent–child relationship, and reactive and proactive aggression whereas children reported on self-perception and social information processing. Results give support for both child social cognitive functioning and parenting as risk factors associated with aggressive behavior: For all children, a positive parent–child relationship was associated with less aggression, negative parenting was related to less positive self-perception, and deficits in social-cognitive functioning were related to aggression. Multigroup analyses showed ethnic similarities and sex differences in patterns of associations, which might suggest personalized tailor-made interventions for aggressive behavior.     

The Effectiveness of Group Metacognitive Therapy for Generalised Anxiety Disorder: A Pilot Study

Generalised anxiety disorder (GAD) responds well to individually delivered metacognitive therapy (MCT). The current study investigated the effectiveness of MCT administered to groups of patients with GAD in a general outpatient treatment centre. Thirty-three consecutively referred adult patients with GAD were assessed before treatment (pretreatment), after the last treatment session (posttreatment), and six months after treatment had ended (follow-up). Analyses of treatment effects were conducted for all patients entering the study (i.e., intent-to-treat analysis, using the last-observation-carried-forward procedure), and repeated for the patients who completed treatment (completers analysis), using paired samples t-tests. Further, effect sizes (ESs) and indices of clinical significance were calculated, and compared with those reported in studies into the efficacy and effectiveness of individually delivered MCT for GAD. Among both the intent-to-treat and the completers sample, large pre- to posttreatment reductions in symptoms of worry, trait-anxiety, and general psychopathology. The magnitude of change and the degree of clinical significance were smaller than those reported in studies into the effectiveness of individually delivered MCT for GAD, whereas the attrition rate (27 %) was higher. It is tentatively concluded that MCT for GAD can be effectively delivered in a group format in a heterogenous clinical practice setting. Further evaluation is clearly indicated.