Substance P antagonists: meet the new drugs,same as the old drugs? Insights from transgenic animal models

Antidepressants that primarily target the reuptake of monoamines have been highly successful treatments. However, therapies with these drugs still have several drawbacks, namely severe side effects, delays in the onset of action, and a significant percentage of non-responders. Recently, non-peptidic antagonists of the neurokinin 1 receptor, or substance P antagonists, have emerged as a novel class of drugs with antidepressant efficacy that is comparable to current drugs, but a potentially reduced side effect profile. This review summarizes the pre-clinical evidence derived from pharmacological and transgenic animal studies that suggests an important role for the substance P/neurokinin 1 system in anxiety and depression. Also, potential mechanisms by which substance P antagonists may produce their therapeutic effects are discussed.     

Consequences of Children's Exposure to Community Violence

Much has been learned over the past decade about the way children respond to experiences of violence in their community. The goal of this paper is to review what is known about the effects of community violence on children's development. In addition to main effects, factors that mediate these effects, as well as factors that moderate children's response to community violence are discussed. Special attention is paid to developmental differences in children's responses to community violence and the factors that may promote resilient functioning.     

Acknowledgment of Reviewers

Dedication

Acknowledgment of Reviewers     

The intelligent brain in conflict

Can individual differences in general reasoning ability be reduced to an elementary cognitive process or isolated to a neural circuit? A breakthrough neuroimaging study finds that fluid intelligence and attention control are behaviorally linked via the neural activity in brain areas involved in resolving cognitive conflict.     

Contents of Volume 9

Volume Contents

Contents of Volume 9     

Instructions for Authors

Instructions for Authors

Instructions for Authors     

Information search in the laboratory and on the Web: With or without an experimenter

The focus of this study is the effect of the location (laboratory vs. Web) of experiments on active information searchin decision-making tasks. In two experiments, participants were confronted with two different search method versions (list vs. keyword) for acquiring information about a task from a database. The amount and type of information gathered and the time required for task completion were measured. In Experiment 1, significantly more information was searched for in the laboratory than on the Web when the list version was employed, whereas there was no difference between locations in the keyword version. In Experiment 2, the participants were assigned randomly to the Web or the laboratory condition. The results of Experiment 1 were replicated. Whereas location (and the presence or absence of an experimenter) had an effect on the absolute amount of information gathered in both experiments, the relative distribution and type of information items did not differ.     

Promoting responsible conduct in research through “survival skills” workshops: Some mentoring is best done in a crowd

For graduate students to succeed as professionals, they must develop a set of general "survival skills". These include writing research articles, making oral presentations, obtaining employment and funding, supervising, and teaching. Traditionally, graduate programs have offered little training in many of these skills. Our educational model provides individuals with formal instruction in each area, including their ethical dimensions. Infusion of research ethics throughout a professional skills curriculum helps to emphasize that responsible conduct is integral to succeeding as a researcher. It also leads to the consideration of ethical dimensions of professional life not covered in traditional ethics courses.