Alpha3-integrins are required for hippocampal long-term potentiation and working memory

Integrins comprise a large family of heterodimeric, transmembrane cell adhesion receptors that mediate diverse neuronal functions in the developing and adult CNS. Recent pharmacological and genetic studies have suggested that beta1-integrins are critical in synaptic plasticity and memory formation. To further define the role of integrins in these processes, we generated a postnatal forebrain and excitatory neuron-specific knockout of alpha3-integrin, one of several binding partners for beta1 subunit. At hippocampal Schaffer collateral-CA1 synapses, deletion of alpha3-integrin resulted in impaired long-term potentiation (LTP). Basal synaptic transmission and paired-pulse facilitation were normal in the absence of alpha3-integrin. Behavioral studies demonstrated that the mutant mice were selectively defective in a hippocampus-dependent, nonmatch-to-place working memory task, but were normal in other hippocampus-dependent spatial tasks. The impairment in LTP and working memory is similar to that observed in beta1-integrin conditional knockout mice, suggesting that alpha3-integrin is the functional binding partner for beta1 for these processes in the forebrain.     

A New Framework for Comparative Study of Philosophy

The aim of this essay is to outline a conceptual framework for a type of philosophy (or approach to philosophy) to be herein called “non-sentential philosophy.” Although I will primarily concern myself with the conceptual coherence of the framework in this essay, illustrations will be provided to show that the notion has rich implications for comparative studies. In particular, I believe this theoretical framework will be of interest to those looking for a way to capture the differences between certain non-Western philosophical traditions—such as Chinese philosophy—and Western philosophy, a tradition in which the sentential approach is dominant.     

生存论向度的技术伦理前提及其建构

技术伦理涉及价值观基础、道德规范、技术主体的责任等诸多问题.无论是传统的元伦理学、情感主义伦理学、规范伦理学还是所谓的实用伦理学,都只是从某一个维度上或在某一个层面上来阐述伦理问题,从而在一定程度上表现为对于人的生存价值的背离和对发展合理性的伦理诉求的缺失,这样就使技术伦理研究本身在某种程度上失去了应有的合理性.在合理性上,技术伦理研究不能脱离开对技术本质属性的认识和基本的理论前提.从生存论的向度审视,生存价值才是伦理的内在价值基础,而发展的合理性才是技术伦理建构的基本逻辑支点.只有在此基础上,技术伦理才能实现合理的建构.     

小学高年级儿童亲子依恋的发展及其与同伴交往的关系

以武汉市三所普通小学四、五、六年级的505名学生为被试,用问卷调查、团体施测的方式,探讨亲子依恋与其同伴交往的关系,结果发现:儿童的母—子依恋安全性得分和对父母的信赖有显著年级差异,表现为随着年级的增长而下降,同时母—子依恋安全性得分显著高于父—子依恋;在儿童友谊质量、社交焦虑方面,父、母均有影响,在社会交往行为表现及好朋友提名分方面母亲的作用也是显见的;与双亲建立了双重安全依恋型的儿童获益最大,双重非安全依恋型的儿童损失最惨重。     

任法融会长捐资援建的希望小学举行落成典礼

中国道教协会七届二次理事会议于2007年9月19日上午在北京温都水城国际大酒店召开。出席会议的第七届理事会理事应到121人,实到97人。中国道教协会第七届理事会会长任法融,     

中国道教协会会长任法融一行赴港参加蓬瀛仙馆八十周年馆庆系列活动

应香港蓬瀛仙馆邀请,2009年5月7日至13日,中同道教协会会长任法融一行5人及北京白云观经乐团23人赴港访问,参加香港蓬瀛仙馆八十周年馆庆系列活动.同时应邀出席活动的还有国家宗教局副局长蒋坚永、研究中心主任张训谋,台北指南宫董事长高忠信等.北京白云观经乐团与香港蓬瀛仙馆、台北指南官共同肩建的"两岸三地祈福法会"于5月8日至11日举行,祈愿世界经济早日复苏,流感疫情得以扑灭,并预祝年底在香港举行的东亚运动会圆满成功.     

青少年生命认知及其生活满意度的干预研究

按学段自行编写生命教育活动课程教案,随机抽取7年级和10年级各一个班学生作为生命教育活动课程的实施对象,进行为期一个学期的生命教育。结果发现:(1)以生命教育为主题的课程实施提升了儿童对亲子关系和整体生命评价的满意度,从而使得青少年的生命认知得到进一步正向发展和积极深化;(2)通过生命教育,加强了青少年对生命过程和死亡现象的概念性理解和情绪性表达,推动个体从一种更具逻辑性的、积极的视角和态度去感恩生命的存在,理解死亡的必然。     

What if Wittgenstein could speak Japanese?

ABSTRACT

Wittgenstein’s criticism of the notion of ‘private language’ is related to the putative centrality of “being“ and the ‘subject-predicate’ distinction . However, his efforts would prove to be more fruitful if he could use data from Japanese language. There is a list of Japanese terms to translate ‘being’: sonzai, de-aru, ga-aru, and iru. Among all of their variants, the only subject-predicate-form-related expression is the combination of the ‘Y ga Z aru’-part of ‘X wa Y ga Z aru.’ Hence, Japanese subject-predicate-form-related expressions are not as fundamental as their western counterparts. Insofar as ‘pain’ is concerned, in Japanese, there are two series of expressions on pain: in the first one, the notion of pain is deobjectied and hence immune to subject-predicate logic, while in the second one, it is barely objectified in a limited sense. Hence, a Japanese speaker could avoid the fallacy of attributing subjective sensations to a particular person.     

To Stay or Return: Migration Intentions of Students from People’s Republic of China in Saskatchewan, Canada

There is a growing policy concern in Canada regarding the facilitation of foreign students’ transition from temporary residents to permanent residents. Interestingly, academic attention to the issue is somewhat lacking. By focusing on the Chinese undergraduate student at the University of Saskatchewan in Canada, this study attempts to identify the factors which influence their migration intentions. The findings confirm the important effects of students’ demographic characteristics, premove traits, Canadian experiences, parental expectations, as well as related aspiration factors. In addition, we find that female and male students are different from each other in terms of the factors that determine their intentions to stay in Canada. In light of the findings, we suggest that, in spite of gender differences, social and emotional adaptations are as critical as economic adaptation in facilitating temporary residents’ intentions to stay. Furthermore, we contend that changes in immigration policy to attract foreign students to stay do motivate their immigration intention to some extent, but we also recommend that extended research needs to be done to examine the effects of most recent policy changes on foreign students’ intended or actual migration.