心肌保护基因治疗进展及展望

心肌保护基因治疗的研究目前仍停留在动物实验阶段。本文从哲学的角度论述了心肌保护基因治疗研究的进展与优点,以及存在的安全性、局限性与伦理学方面的问题,并就目前其它领域基因治疗的进展对其作了进一步的展望。     

Are DSM-IV-TR Borderline Personality Disorder, ICD-10 Emotionally Unstable Personality Disorder, and CCMD-III Impulsive Personality Disorder Analogous Diagnostic Categories Across Psychiatric Nomenclatures?

This study examined the validity of the borderline construct which encompasses diagnostic criteria from the DSM-IV-TR Borderline Personality Disorder (BPD), ICD-10 Emotionally Unstable Personality Disorder (EUPD), and CCMD-III Impulsive Personality Disorder (IPD) in a sample of 1,419 Chinese psychiatric patients. Participants completed the Chinese Personality Disorder Inventory and the Chinese Personality Assessment Inventory-2 assessing various disordered personality features. Adequate internal consistency was found for the borderline construct (α = .83). Exploratory factor analysis revealed two components: (1) affective and cognitive disturbances, and (2) impulse dysregulation, which were replicated by confirmatory factor analysis. Item analysis indicated that the various borderline criteria displayed similar levels of diagnostic efficiency, which does not support the elimination of fear of abandonment and transient psychotic features from the EUPD and IPD criteria set. Findings of this study suggest that BPD, EUPD, and IPD may represent analogous diagnostic categories across classification systems.     

Optimism and Coping with Unemployment among Hong Kong Chinese Women

The effects of dispositional optimism and coping on the link between unemployment and psychological health were studied among 79 employed and 104 unemployed Hong Kong Chinese women. Results indicated that optimism, indexed by the Chinese version of the Revised Life Orientation Test (C-RLOT), moderated the effect of unemployment on psychological health. The less optimistic women were more psychologically impaired by losing their jobs. Among the unemployed women, the more optimistic ones and those who were more able to distance themselves from job loss fared better. Nevertheless, coping did not mediate the connection between optimism and psychological outcomes. These findings suggest that optimism is an important personal resource for coping with unemployment in Hong Kong Chinese, but whether coping mediates the effects of optimism on psychological health or not depends on other contextual factors. Ways to ensure more reliable prediction regarding the connections between optimism, coping and psychological health in future research were discussed.     

Book reviews

Women in the Footsteps of the Buddha. Struggle for Liberation in the Therigāthā . Katheryn R. Blackstone, 1998, London, Curzon Press xiv + 186 pp., ISBN 0 7007 0962 2

The Supreme Wisdom of the Upanisads. An Introduction. Klaus G. Witz, 1998, Delhi, Motilal Banarsidass xxv + 558 pp., hb Rs 700, ISBN 81 208 1573 4

The Original Analects: Sayings of Confucius and his Successors. E. Bruce Brooks & A. Takeo Brooks (Trans.), 1998 New York, Columbia University Press 368 pp., ISBN 0 2311 0430 8     

On The Universal and Local Aspects of Confucianism

To counter the tendency of making Confucianism “localized” and thereby turning Confucianism research into research of local social history, the author criticizes this tendency and thinks it is unilateral to emphasize or stress the importance of a small unit’s locality, but ignore the oneness of the distribution of Confucianism and the universality of Confucian thought. The thesis emphasizes that the main schools of Confucianism in the Song and Ming Dynasties are all not local ones and cannot be reduced to reflections of some local need and social structure. The author points out that we need to self-examine the following phenomena: aggrandizing the function of local social structure to culture and thought, coming down academic schools to reflections of local social benefits, opposing this kind of research to the research of thought itself, thus rejecting philosophical research and analysis of thought itself.     

Book reviews

Confucian Traditions in East Asian Modernity: moral education and economic culture in Japan and the four mini‐dragons Tu Wei‐Ming (Ed.), 1996 Cambridge, MA, Harvard University Press ii + 418pp., hb £28.50, pb £12.50, ISBN 0 674 16086 X (hb)

The Recluse of Loyang: Shao Yung and the moral evolution of early Sung thought Don J. Wyatt, 1996 Honolulu, University of Hawaii Press xii + 340 pp., hb (price not given), ISBN 0 8248 1755 9

Rude Awakenings: Zen, the Kyoto School and questions of nationalism James W. Heisig & John C. Maraludo (Eds), 1995 Honolulu, University of Hawaii Press hb $40.00, pb $19.95

Untying the Knots in Buddhism. Selected essays Buddhist Tradition Series Volume 28, 1997 Alex Wayman 1997 Delhi, Motilal Banarsidass x + 618 pp, hb Rs. 495; ISBN 81 208 1321 9

Historical Dictionary of Hinduism Historical Dictionaries of Religions, Philosophies, and Movements, No. 13 Bruce M. Sullivan 1997 Lanham, MD & London, The Scarecrow Press xviii, 346 pp, pb £46.55, ISBN 0 8108 3327 1

Dictionary of Philosophy and Religion. Eastern and Western thought (New and enlarged edition; first 1980) William L. Reese, 1996 New York, Humanities Press xiv + 856 pp., pb, ISBN 0 391 03864 8     

任继愈先生与中国哲学史

1978年,还在我上研究生之初,看到《哲学研究》上任先生写的一篇文章,其中说解放以后,他信从马克思主义,就跟他以前的老师说,今后他不再相信旧哲学,要走新哲学的路(大意)。我当时读了以为是指汤用彤先生。后来读书渐多,始知乃是指熊十力先生。任先生在北大毕业,在西南联大念研究生,但早期思想并未受胡适的特别影响,而是与熊十力、贺麟等来往颇多。     

The occlusion illusion: partial modal completion or apparent distance?

In the occlusion illusion, the visible portion of a partly occluded object (eg a semicircle partly hidden behind a rectangle) appears to be significantly larger than a physically identical region that is fully visible. This illusion may occur either because the visual system 'fills in' a thin strip along the occluded border (the partial-modal-completion hypothesis) or because the partly occluded object is perceived as farther away (the apparent-distance hypothesis). We measured the magnitude of the occlusion illusion psychophysically in several experiments to investigate its causes. The results of experiments 1-3 are consistent with the general proposal that the magnitude of the illusion varies with the strength of the evidence for occlusion, supporting the inference that it is due to occlusion. Experiment 4 provides a critical test between apparent-distance and partial-modal-completion explanations by determining whether the increase in apparent size of the occluded region results from a change in its perceived shape (due to the modal extension of the occluded shape along the occluding edge, as predicted by the partial-modal-completion hypothesis) or from a change in its perceived overall size (as predicted by the apparent-distance hypothesis). The results more strongly support the partial-modal-completion hypothesis.     

瘢痕治疗的选择与思考

瘢痕作为人类最常见的疾病之一,其治疗一直是整形外科界研究的热点和焦点。本文从治疗方法的发展过程,认识到科学的认识论对方法论具有良好的指导作用,满意的治疗其根本在于提高医生的素质,从哲学角度对如何科学的选择治疗方法进行总结,指明从根本上解决瘢痕,最终要依靠现代发达的基础科学研究。