Measuring illness representations in breast cancer survivors (BCS) prescribed tamoxifen: Modification and validation of the Revised Illness Perceptions Questionnaire (IPQ-BCS)

Objective: The Revised Illness Perceptions Questionnaire (IPQ-R), widely used to assess illness perceptions, may fail to measure unique characteristics of different illnesses. This study modified and validated the IPQ-R for breast cancer survivors to provide detailed understanding of the specific illness perceptions held by these patients.

Design: Initial modifications were made following qualitative interviews and were revised in a think-aloud study. The modified scale was tested in 753 breast cancer survivors prescribed tamoxifen. Modifications included adding a tamoxifen consequences scale and adapting the timeline scales to measure beliefs around risk of recurrence and cure. A confirmatory factor analysis was conducted on the modified questionnaire and an exploratory factor analysis on the causal beliefs scale. Test–retest reliability, internal consistency and construct validity were also examined.

Results: The proposed eight-factor structure showed acceptable model fit, with high loadings and good reliability for all subscales. Correlations between subscales were consistent with theory and previous research.

Conclusions: The IPQ-BCS is valid and reliable, and provides unique understanding of specific perceptions held by this population, including beliefs surrounding risk of recurrence and consequences of ongoing hormonal treatment. Identifying these perceptions will aid development of interventions targeting depression, fear of recurrence and medication non-adherence.     

Yohimbine impairs extinction of cocaine-conditioned place preference in an alpha2-adrenergic receptor independent process

Extinction, a form of learning that has the ability to reshape learned behavior based on new experiences, has been heavily studied utilizing fear learning paradigms. Mechanisms underlying extinction of positive-valence associations, such as drug self-administration and place preference, are poorly understood yet may have important relevance to addiction treatment. Data suggest a major role for the noradrenergic system in extinction of fear-based learning. Employing both pharmacological and genetic approaches, we investigated the role of the alpha(2)-adrenergic receptor (alpha(2)-AR) in extinction of cocaine-conditioned place preference (CPP) and glutamatergic transmission in the bed nucleus of the stria terminalis (BNST). We found that pre-extinction systemic treatment with the alpha(2)-AR antagonist yohimbine impaired cocaine CPP extinction in C57BL/6J mice, an effect that was not mimicked by the more selective alpha(2)-AR antagonist, atipamezole. Moreover, alpha(2A)-AR knockout mice exhibited similar cocaine CPP extinction and exacerbated extinction impairing effects of yohimbine. Using acute brain slices and electrophysiological approaches, we found that yohimbine produces a slowly evolving depression of glutamatergic transmission in the BNST that was not mimicked by atipamezole. Further, this action was extant in slices from alpha(2A)-AR knockout mice. Our data strongly suggest that extinction-modifying effects of yohimbine are unlikely to be due to actions at alpha(2A)-ARs.     

Linking form and motion in the primate brain

Understanding dynamic events entails the integration of information about form and motion that is crucial for fast and successful interactions in complex environments. A striking example of our sensitivity to dynamic information is our ability to recognize animate figures by the way they move and infer motion from still images. Accumulating evidence for form and motion interactions contrasts with the traditional dissociation between shape and motion-related processes in the ventral and dorsal visual pathways. By combining findings from physiology and brain imaging it can be demonstrated that the primate brain converts information about spatiotemporal sequences into meaningful actions through interactions between early and higher visual areas processing form and motion and frontal-parietal circuits involved in the understanding of actions.     

Less willing to pay but more willing to buy: How the elicitation method impacts the valuation of a promotion

Willingness to pay (WTP—how much one is willing to pay for something) and willingness to buy (WTB—whether one is willing to buy something at a given price) are two common methods to elicit valuations and normatively should yield the same valuation order between two options. However, this research finds that WTP and WTB can yield opposite valuation orders between the regular offer and the promotional offer of a product. Specifically, it demonstrate that, (a) if the valuation of a product is only elicited with WTP, consumers value the product less when it is offered with a price promotion than when it is not; (b) if the valuation of a product is only elicited with WTB, consumers value the product more when it is offered with a price promotion than when it is not; and (c) if the valuation of a product is first elicited with WTP and then elicited with WTB, consumers always value the product less when it is offered with a price promotion than when it is not. A value‐inference account is proposed for the above findings, according to which, consumers infer the value of a promoted product differently when the valuation is elicited only with WTP or only with WTB. Theoretically, this research extends prior literature on sales promotion, showing that the valuation of a promotion is subject to the elicitation method. Practically, this research suggests how to help consumers manage their purchase intentions for promoted products.     

The possessions at Loudun: tracking the discourse of dissociation

Embedded in the history of dissociation is the best known case of possession in European history, the 17^th century possessions at Loudun, France (1632‐1638). The exorcisms and the trial drew crowds from all over Europe, the outcome prefiguring the direction in which the Western science of mind would be carried. The published debate about the possessed and obsessed Ursuline nuns of Loudun spans four centuries. One can track how theorizing about dissociation changed over time, with psychological contributions by Jean Martin Charcot, Georges Gilles de la Tourette, Pierre Janet, Michel Foucault and Michel de Certeau. Freud's psychoanalytic notion of demonological neurosis emphasized defensive strategies and a diabolic parody of adulthood. Jung's concepts of demonism and possession highlighted dissociated complexes that assimilate the ego and unseat the self, rendering a life ‘provisional’. Dissociation as possession provides a through‐line in Jung's Collected Works, from his 1902 dissertation to one of the last essays he wrote, in 1961. Within the context of psychotherapy, therapists and patients work towards psychological containment, consciously reorienting themselves to the presence of unconscious factors, personifying, embodying and thereby incorporating images of dissociated Otherness into the experience of selfhood.     

The effects of explicit “Not Present” and “Don't Know” response options on identification decisions in computer-administered lineups

Eyewitness researchers recommend that “not present” and “don't know” response options should be presented with police lineups. Although it is important that witnesses—most of whom are unlikely to be familiar with the identification task—are fully cognizant of all response options available to them, an understanding of how explicit non-identification options affect performance is lacking. Across four experiments, including 3,633 participants and 8 different stimulus sets, we tested the effects of including non-identification options in computer-administered lineups. When explicit non-identification options were presented, target-present and -absent choosing decreased. This decrease in choosing was characterized by a shift from filler identifications to lineup rejections. ROC analyses revealed that there was no overall difference in discriminability between guilty and innocent suspects depending on response option condition. On balance, the findings suggest that, in addition to informing witnesses about acceptable responses, displaying non-identification response options does not undermine identification performance.     

Prototypes of Discrimination: How Status Asymmetry and Stereotype Asymmetry Affect Judgments of Racial Discrimination

This research investigated status asymmetry and stereotype asymmetry features of the racial discrimination prototype. Consistent with status asymmetry predictions, Black observers made greater attributions to discrimination when the victim was Black and the perpetrator was White than when the roles were reversed. In contrast, White observers made similar attributions to discrimination, regardless of status asymmetry. In partial support of the stereotype asymmetry hypothesis, Black and White observers made greater attributions to discrimination for Black victims in a domain where Blacks are negatively stereotyped than positively stereotyped. However, attributions to discrimination for White victims were unaffected by the domain.