途径偏向矫正训练对药物成瘾相关线索反应的调节

研究目的:通过针对"相关线索-习惯性用药行为"联结的消退训练,降低渴求感,建立新联结,达到减弱或消退成瘾记忆的目的。探索以"动作消退动作"的方法对成瘾动作记忆进行消退的效果和可行性。方法:采用途径偏向矫正方法对28名男性药物成瘾者开展为期4周的训练。训练前后,分别测试渴求感、生理指标、途径偏向效应和Addiction-stroop task的干扰效应量,比较训练前后的指标变化,了解训练的效果。结果:训练组和对照组在训练前后的途径偏向效应没有显著的组间和交互效应,但训练组在训练前后途径偏向效应发生变化,趋向显著性,t=1.26,p=0.071。渴求感在训练组显著降低:t=1.38,p=0.05。Stroop的反应时间呈训练时间主效应:t=4.18,p=0.04。结论:途径偏向矫正消退训练可以改善成瘾者的途径偏向效应和渴求感状况,预示着通过身体动作建立"相关线索-拒绝用药行为"联结替代原有的"相关线索-自动化用药行为"联结,降低渴求感,减弱或消退成瘾记忆是有可能的。未来的研究需要采用更为精确的影像手段进行测试,验证基于动作认知的成瘾记忆消退训练的有效性。     

Serotonin transporter 5-HTTLPR genotype is associated with intrusion and avoidance symptoms of DSM-5 posttraumatic stress disorder (PTSD) in Chinese earthquake survivors

Background and Objectives: Prior studies have found that the serotonin transporter gene-linked polymorphic region (5-HTTLPR) interacts with trauma exposure to increase general risk for Posttraumatic Stress Disorder (PTSD). However, there is little knowledge about the effects of the interaction on distinct symptom clusters of PTSD. This study aimed to investigate the relation between the interaction of 5-HTTLPR and earthquake-related exposures and a contemporary phenotypic model of DSM-5 PTSD symptoms in a traumatised adult sample from China.

Design: A cross-sectional design with gene-environment interaction (G?×?E) approach was adopted. Methods: Participants were 1131 survivors who experienced 2008 Wenchuan earthquake. PTSD symptoms were assessed with the PTSD Checklist for DSM-5 (PCL-5). The 5-HTTLPR polymorphism was genotyped with capillary electrophoresis (CE) in ABI 3730xl genetic Analyzer.

Results: Although there was no significant interaction between 5-HTTLPR and traumatic exposure on total PTSD symptoms, respondents with the LL genotype of 5-HTTLPR who were highly exposed to the earthquake experienced lower intrusion and avoidance symptoms than those with the S-allele carriers.

Conclusions: The findings suggest that the 5-HTTLPR may have an important impact on the development of PTSD and add to the extant knowledge on understanding and treating of posttraumatic psychopathology.     

A diathesis-stress model of engagement in risky behaviors in Chinese adolescents

The current study examined whether the association between the occurrence of negative events and increased engagement in risky behavior is moderated by maladaptive and/or adaptive coping strategies. At time 1, 411 adolescents (ages 14–19) from Yue Yang, Hunan, completed self-report measures assessing coping strategies, engagement in risky behaviors, and the occurrence of negative events. Once a month for the subsequent 6 months, adolescents completed measures assessing engagement in risky behaviors and the occurrence of negative events. In line with our hypotheses, results of hierarchical linear modeling analyses indicated that adolescents possessing high levels of maladaptive coping strategies reported greater engagement in risky behaviors following the occurrence of negative events than adolescents possessing low levels. In contrast to our hypotheses, the association between the occurrence of negative events and increased engagement in risky behavior was not moderated by adaptive coping strategies.     

The Impact of Perceived Discrimination on Mental Health Among Chinese Migrant and Left-Behind Children: A Meta-analysis

In China, rural–urban migration is one of major influences on the mental health of migrant and left-behind children. Literature suggests that the perception of discrimination is an important factor that influences the mental health of these children. The present research explores (1) whether migrant children and left-behind children are different in the relationship between the perception of discrimination and mental health, and (2) whether the relationship between the perception of discrimination and mental health of these children is moderated by gender and age. Using a meta-analytic technique, the authors included 26 studies (generating 48 independent samples) with a total sample size of 28,883 participants. Results showed that the perception of discrimination of migrant children was negatively correlated with positive indicators of mental health, and it has a stronger effect than left-behind children; the perception of discrimination of migrant children was positively correlated with negative indicators of mental health, and it has a weaker effect than left-behind children. Additionally, gender moderated the relationship between the perception of discrimination and the positive indicators of mental health among left-behind children, while age moderated such relationship among migrant children.

     

Distinct processing for pictures of animals and objects: evidence from eye movements

Many studies have suggested that emotional stimuli orient and engage attention. There is also evidence that animate stimuli, such as those from humans and animals, cause attentional bias. However, categorical and emotional factors are usually mixed, and it is unclear to what extent human context influences attentional allocation. To address this issue, we tracked participants' eye movements while they viewed pictures with animals and inanimate images (i.e., category) as focal objects. These pictures had either negative or neutral emotional valence, and either human body parts or nonhuman parts were near the focal objects (i.e., context). The picture's valence, arousal, position, size, and most of the low-level visual features were matched across categories. The results showed that nonhuman animals were more likely to be attended to and to be attended to for longer times than inanimate objects. The same pattern held for the human contexts (vs. nonhuman contexts). The effects of emotional valence, category, and context interacted. Specifically, in images with a negative valence, focal animals and objects with human context had comparable numbers of gaze fixations and gaze duration. These results highlighted the attentional bias to animate parts of a picture and clarified that the effects of category, valence, and picture context interacted to influence attentional allocation.     

多级评分模型下的题库结构对CAT的影响分析

在多级评分模型下,项目的难度参数或步骤参数有多个,在对多级评分模型进行选题时,通常对项目的多个难度参数用一个综合的指标来概括.当对每个项目的难度参数进行有效的综合后,综合后的难度参数分布发生了改变,这时如果增加适量的平均难度较难或较易的项目进入题库,测验的精度和项目的曝光率都有一定的改善.     

丹丘子——仙家道人之通称

丹丘、丹丘山、丹丘子、丹丘生、丹丘羽人……是古诗文和道家文献经常提到的,尤其是被誉为茶圣的唐代隐士陆羽(733-804),先后四次在<茶经>和<顾渚山记>中引述<神异记>提及丹丘子,余姚人虞洪遇丹丘子获大茗的故事因此广为茶人熟知.专家、学者对丹丘子各有见解,有些则明显有误.综合多种文献,笔者以为丹丘子是众多仙家道人的通称或别号.     

“官场迷信”呼唤理论发展

近年来,我国出现了严重的官场迷信现象,这与我们党的宗旨是格格不入的,对于社会主义事业有着严重的危害,很多文章对此做出了谴责,并提出了种种解决方法。然而,其中一个重要的解决方法并没有被提及,这就是理论发展。我们知道,马克思主义既是严整的科学理论, 又是崇高的价值追求,这两者是内在统一的。作为     

Effects of psychological interventions for patients with osteoarthritis: a systematic review and meta-analysis

The aim of this study was to determine the effects of psychological interventions (e.g. cognitive restructuring, relaxation) on physiological and psychological health in osteoarthritis patients. A systematic literature search was done using PubMed, Embase, PsycINFO, Web of Science, China National Knowledge Infrastructure, and Wanfang Database through November 2016. Studies were included if they used a randomized controlled trial designed to explore the effects of psychological interventions in osteoarthritis patients. Two independent authors assessed the methodological quality of the trials using criteria outlined by Jadad et al. Meta-analysis was done with the Revman5.0. Twelve randomized controlled trials, including 1307 osteoarthritis patients, met the study inclusion criteria. Meta-analysis showed that psychological interventions could reduce the levels of pain [standard mean difference (SMD) ?0.28, 95% CI ?0.48, ?0.08, P-value 0.005)] and fatigue (SMD ?0.18, 95% CI ?0.34, ?0.01, P-value 0.04). In addition, psychological interventions significantly improved osteoarthritis patients’ self-efficacy (SMD 0.58, 95% CI 0.40, 0.75, P-value 0.00) and pain coping (MD 1.64, 95% CI 0.03, 3.25, P-value 0.05). Although the effects on physical function, anxiety, depression, psychological disability were in the expected direction, they were not statistically significant. In conclusion, the role of psychological interventions in the management of osteoarthritis remains equivocal. Some encouraging results were seen with regard to pain, pain coping, self-efficacy, and fatigue. We believe that more methodologically rigorous large-scale randomized controlled trials are necessary to answer this study question.     

Atomic imaging of the interface between M23C6-type carbide and matrix in a long-term ageing polycrystalline Ni-based superalloy

Besides the well-known cube-on-cube orientation relationship (OR) between M₂₃C₆ carbide and matrix, we have determined a new OR named as the twin-related OR in a long-term ageing Ni-based superalloy on the basis of the extensive and detailed electron diffraction analyses. Furthermore, by means of atomic-resolution high angle annular dark-field imaging technique which is implemented in the aberration-corrected scanning transmission electron microscope, we elucidated the interfacial characteristics between M₂₃C₆ and matrix for above two types of ORs. Taking into account of the interfacial characteristics, we propose that the twin-related OR possesses a higher total interfacial energy. Thus, its frequency of occurrence is lower than that of the cube-on-cube OR though both ORs are usually seen in the long-term ageing samples.