Exposure to severe urban air pollution influences cognitive outcomes, brain volume and systemic inflammation in clinically healthy children

Exposure to severe air pollution produces neuroinflammation and structural brain alterations in children. We tested whether patterns of brain growth, cognitive deficits and white matter hyperintensities (WMH) are associated with exposures to severe air pollution. Baseline and 1 year follow-up measurements of global and regional brain MRI volumes, cognitive abilities (Wechsler Intelligence Scale for Children-Revised, WISC-R), and serum inflammatory mediators were collected in 20 Mexico City (MC) children (10 with white matter hyperintensities, WMH⁺, and 10 without, WMH⁻) and 10 matched controls (CTL) from a low polluted city. There were significant differences in white matter volumes between CTL and MC children - both WMH⁺ and WMH⁻ - in right parietal and bilateral temporal areas. Both WMH⁻ and WMH⁺ MC children showed progressive deficits, compared to CTL children, on the WISC-R Vocabulary and Digit Span subtests. The cognitive deficits in highly exposed children match the localization of the volumetric differences detected over the 1 year follow-up, since the deficits observed are consistent with impairment of parietal and temporal lobe functions. Regardless of the presence of prefrontal WMH, Mexico City children performed more poorly across a variety of cognitive tests, compared to CTL children, thus WMH⁺ is likely only partially identifying underlying white matter pathology. Together these findings reveal that exposure to air pollution may perturb the trajectory of cerebral development and result in cognitive deficits during childhood.     

The influence of emotion on lexical processing: Insights from RT distributional analysis

In two lexical decision experiments, the present study was designed to examine emotional valence effects on visual lexical decision (standard and go/no-go) performance, using traditional analyses of means and distributional analyses of response times. Consistent with an earlier study by Kousta, Vinson, and Vigliocco (Cognition 112:473–481, 2009), we found that emotional words (both negative and positive) were responded to faster than neutral words. Finer-grained distributional analyses further revealed that the facilitation afforded by valence was reflected by a combination of distributional shifting and an increase in the slow tail of the distribution. This suggests that emotional valence effects in lexical decision are unlikely to be entirely mediated by early, preconscious processes, which are associated with pure distributional shifting. Instead, our results suggest a dissociation between early preconscious processes and a later, more task-specific effect that is driven by feedback from semantically rich representations.     

Effects of a Multilevel Resilience-Based Intervention on Mental Health for Children Affected by Parental HIV: A Cluster Randomized Controlled Trial

Journal of Child and Family Studies - The present study aimed to examine the efficacy of the Child-Caregiver-Advocacy Resilience (ChildCARE) intervention, a multilevel resilience-based psychosocial...     

The Impact of Perceived Discrimination on Mental Health Among Chinese Migrant and Left-Behind Children: A Meta-analysis

In China, rural–urban migration is one of major influences on the mental health of migrant and left-behind children. Literature suggests that the perception of discrimination is an important factor that influences the mental health of these children. The present research explores (1) whether migrant children and left-behind children are different in the relationship between the perception of discrimination and mental health, and (2) whether the relationship between the perception of discrimination and mental health of these children is moderated by gender and age. Using a meta-analytic technique, the authors included 26 studies (generating 48 independent samples) with a total sample size of 28,883 participants. Results showed that the perception of discrimination of migrant children was negatively correlated with positive indicators of mental health, and it has a stronger effect than left-behind children; the perception of discrimination of migrant children was positively correlated with negative indicators of mental health, and it has a weaker effect than left-behind children. Additionally, gender moderated the relationship between the perception of discrimination and the positive indicators of mental health among left-behind children, while age moderated such relationship among migrant children.

     

多级评分模型下的题库结构对CAT的影响分析

在多级评分模型下,项目的难度参数或步骤参数有多个,在对多级评分模型进行选题时,通常对项目的多个难度参数用一个综合的指标来概括.当对每个项目的难度参数进行有效的综合后,综合后的难度参数分布发生了改变,这时如果增加适量的平均难度较难或较易的项目进入题库,测验的精度和项目的曝光率都有一定的改善.     

Effects of psychological interventions for patients with osteoarthritis: a systematic review and meta-analysis

The aim of this study was to determine the effects of psychological interventions (e.g. cognitive restructuring, relaxation) on physiological and psychological health in osteoarthritis patients. A systematic literature search was done using PubMed, Embase, PsycINFO, Web of Science, China National Knowledge Infrastructure, and Wanfang Database through November 2016. Studies were included if they used a randomized controlled trial designed to explore the effects of psychological interventions in osteoarthritis patients. Two independent authors assessed the methodological quality of the trials using criteria outlined by Jadad et al. Meta-analysis was done with the Revman5.0. Twelve randomized controlled trials, including 1307 osteoarthritis patients, met the study inclusion criteria. Meta-analysis showed that psychological interventions could reduce the levels of pain [standard mean difference (SMD) ?0.28, 95% CI ?0.48, ?0.08, P-value 0.005)] and fatigue (SMD ?0.18, 95% CI ?0.34, ?0.01, P-value 0.04). In addition, psychological interventions significantly improved osteoarthritis patients’ self-efficacy (SMD 0.58, 95% CI 0.40, 0.75, P-value 0.00) and pain coping (MD 1.64, 95% CI 0.03, 3.25, P-value 0.05). Although the effects on physical function, anxiety, depression, psychological disability were in the expected direction, they were not statistically significant. In conclusion, the role of psychological interventions in the management of osteoarthritis remains equivocal. Some encouraging results were seen with regard to pain, pain coping, self-efficacy, and fatigue. We believe that more methodologically rigorous large-scale randomized controlled trials are necessary to answer this study question.     

Serotonin transporter 5-HTTLPR genotype is associated with intrusion and avoidance symptoms of DSM-5 posttraumatic stress disorder (PTSD) in Chinese earthquake survivors

Background and Objectives: Prior studies have found that the serotonin transporter gene-linked polymorphic region (5-HTTLPR) interacts with trauma exposure to increase general risk for Posttraumatic Stress Disorder (PTSD). However, there is little knowledge about the effects of the interaction on distinct symptom clusters of PTSD. This study aimed to investigate the relation between the interaction of 5-HTTLPR and earthquake-related exposures and a contemporary phenotypic model of DSM-5 PTSD symptoms in a traumatised adult sample from China.

Design: A cross-sectional design with gene-environment interaction (G?×?E) approach was adopted. Methods: Participants were 1131 survivors who experienced 2008 Wenchuan earthquake. PTSD symptoms were assessed with the PTSD Checklist for DSM-5 (PCL-5). The 5-HTTLPR polymorphism was genotyped with capillary electrophoresis (CE) in ABI 3730xl genetic Analyzer.

Results: Although there was no significant interaction between 5-HTTLPR and traumatic exposure on total PTSD symptoms, respondents with the LL genotype of 5-HTTLPR who were highly exposed to the earthquake experienced lower intrusion and avoidance symptoms than those with the S-allele carriers.

Conclusions: The findings suggest that the 5-HTTLPR may have an important impact on the development of PTSD and add to the extant knowledge on understanding and treating of posttraumatic psychopathology.     

服务型领导对员工建言行为的影响:领导-成员交换和学习目标取向的作用

通过对191名员工及其领导的配对问卷调查,探讨了服务型领导对员工建言行为的作用机制。结果发现:(1)服务型领导对员工建言行为有积极影响;(2)服务型领导通过领导-成员交换的中介效应影响员工建言行为;(3)员工的学习目标取向对领导-成员交换与建言行为之间的关系具有调节效应,即员工的学习目标取向越强,领导-成员交换对建言行为的影响越大;(4)学习目标取向调节了领导-成员交换对服务型领导-建言行为的中介作用。     

Atomic imaging of the interface between M23C6-type carbide and matrix in a long-term ageing polycrystalline Ni-based superalloy

Besides the well-known cube-on-cube orientation relationship (OR) between M₂₃C₆ carbide and matrix, we have determined a new OR named as the twin-related OR in a long-term ageing Ni-based superalloy on the basis of the extensive and detailed electron diffraction analyses. Furthermore, by means of atomic-resolution high angle annular dark-field imaging technique which is implemented in the aberration-corrected scanning transmission electron microscope, we elucidated the interfacial characteristics between M₂₃C₆ and matrix for above two types of ORs. Taking into account of the interfacial characteristics, we propose that the twin-related OR possesses a higher total interfacial energy. Thus, its frequency of occurrence is lower than that of the cube-on-cube OR though both ORs are usually seen in the long-term ageing samples.