On the Respective Roles of Nitric Oxide and Carbon Monoxide in Long-Term Potentiation in the Hippocampus

Perfusion of hippocampal slices with an inhibitor nitric oxide (NO) synthase blocked induction of long-term potentiation (LTP) produced by a one-train tetanus and significantly reduced LTP by a two-train tetanus, but only slightly reduced LTP by a four-train tetanus. Inhibitors of heme oxygenase, the synthetic enzyme for carbon monoxide (CO), significantly reduced LTP by either a two-train or four-train tetanus. These results suggest that NO and CO are both involved in LTP but may play somewhat different roles. One possibility is that NO serves a phasic, signaling role, whereas CO provides tonic, background stimulation. Another possibility is that NO and CO are phasically activated under somewhat different circumstances, perhaps involving different receptors and second messengers. Because NO is known to be activated by stimulation of NMDA receptors during tetanus, we investigated the possibility that CO might be activated by stimulation of metabotropic glutamate receptors (mGluRs). Consistent with this idea, long-lasting potentiation by the mGluR agonist tACPD was blocked by inhibitors of heme oxygenase but not NO synthase. Potentiation by tACPD was also blocked by inhibitors of soluble guanylyl cyclase (a target of both NO and CO) or cGMP-dependent protein kinase, and guanylyl cyclase was activated by tACPD in hippocampal slices. However, biochemical assays indicate that whereas heme oxygenase is constitutively active in hippocampus, it does not appear to be stimulated by either tetanus or tACPD. These results are most consistent with the possibility that constitutive (tonic) rather than stimulated (phasic) heme oxygenase activity is necessary for potentiation by tetanus or tACPD, and suggest that mGluR activation stimulates guanylyl cyclase phasically through some other pathway.     

Inflammation Causes a Long-Term Hyperexcitability in the Nociceptive Sensory Neurons of Aplysia

Nerve injury, tissue damage, and inflammation all cause hyperalgesia. A factor contributing to this increased sensitivity is a long-term (>24 hr) hyperexcitability (LTH) in the sensory neurons that mediate the responses. Using the cluster of nociceptive sensory neurons in Aplysia californica as a model, we are examining how inflammation induces LTH. A general inflammatory response was induced by inserting a gauze pad into the animal. Within 4 days, the gauze is enmeshed in an amorphous material that contains hemocytes, which comprise a cellular immune system. Concurrently, LTH appears in both ipsilateral and contralateral sensory neurons. The LTH is manifest as increased action potential discharge to a normalized stimulus. Immunocytochemistry revealed that hemocytes have antigens recognized by antibodies to TGFβ1, IL-6, and 5HT. When a localized inflammation was elicited on a nerve, hemocytes containing the TGFβ1 antigen were present near axons within the nerve and those containing the IL-6 were on the surface. Western blots of hemocytes, or of gauze that had induced a foreign body response, contained a 28-kD polypeptide recognized by the anti-TGFβ1 antibody. Exposure of the nervous system to recombinant human TGFβ1 elicited increased firing of the nociceptive neurons and a decrease in threshold. The TGFβ1 also caused an activation of protein kinase C (PKC) in axons but did not affect a kinase that is activated in axons after injury. Our findings, in conjunction with previous results, indicate that a TGFβ1-homolog can modulate the activity of neurons that respond to noxious stimuli. This system could also contribute to interactions between the immune and nervous systems via regulation of PKC.     

《吕氏春秋》领导心理思想研究

该文认为《吕氏春秋》蕴涵着丰富的领导心理思想。文章从领导者的个体心理过程,领导者的品质特征,领导者的权变思想,领导者的用人心理四个方面论述其领导心理思想。     

《淮南子》人力管理的心理学思想

本文认为《淮南子》管理心理学思想,是对先秦道家的继承和发展。文章从人员的甄选心理、任用心理、激励心理三个方面对其中人力管理心理学思想作了整理。     

目标－背景色的配合对彩色CRT显示工效的影响

以通道容量为作业效标,用实验方法对ＣＲＴ显示屏上黑、深蓝、绿、浅蓝、红、紫、黄、白等８种颜色组成的５６种目标－背景色配合方式与显示工效的关系作了比较研究。结果表明：从工效学考虑,彩色ＣＲＴ显示屏的背景色有以深色为好的趋势,目标色有以浅色为好的趋势。目标与背景色彩的恰当配合能显著提高信息的传递绩效。白目标黑背景、黄目标黑背景、绿目标黑背景等对比度较大的目标－背景配合显示工效最佳。     

运动竞赛状态焦虑量表（CSAI—2问卷）中国常模的修订

该量表是由美国伊利诺斯大学的马腾斯等人（１９９０）以多维的竞赛状态焦虑理论为指导而编制成的．我们在全国二十七个省市各级各类及各种项目的运动队中随机抽取了２,０９９名被试,按照优秀运动员（男、女）,中学（中专）文化程度（男、女）与大学（大专）文化程度（男、女）的样组修订出了中国的六个常模,还修订出６个分项目的常模,共１２个．同时,进行了效度和信度检验。本量表可以用于现场测试运动员（包括业余的、专业的和学生运动员）在进行运动竞赛时的焦虑水平。     

运动竞赛焦虑量表中国常模的修订

运动竞赛焦虑量表是由美国的马腾斯专为运动员编制的特质焦虑量表。它是一种与特定的情境相结合的、能够有效地测出被测者通常在运动竞赛(或游戏)时焦虑水平的量表。我们在全国六大区十四个省市抽取了2,988名被试,修订了10—12岁(男、女),13—15岁(男、女),16—18岁(男、女)和19—25岁(男、女)的八个常模。同时,进行了效度和信度检验。本量表可以作为对业余的或专业的运动员进行运动竞赛焦虑的诊断与研究用。     

加工水平、回想策略与不自觉记忆

本研究有两项实验。实验一包括三种加工水平和三种不自觉记忆测验方式。结果表明,补笔不受加工水平影响。词干补笔是否受加工水平影响与词干补笔可能性的大小无关。实验二采用了问卷技术,在词干补笔测验后要求被试回答他在测验中是否进行了有意回想。结果表明,有意回想的被试对意义加工的单字比对结构加工的单字获得更高的起动效应;而没有回想的被试其结果不受加工水平影响,从而证实,词干补笔也不受加工水平影响。     

Social determinants of health,prenatal maternal stress,and earlier birth during the COVID-19 pandemic

During the COVID-19 pandemic, pregnant women, especially those from socioeconomically disadvantaged and marginalized groups, experienced unprecedented stress. Prenatal stress and social determinants of health (SDoH) such as lower education and lack of a relationship partner are known to contribute to earlier birth. However, whether SDoH and stress independently contribute or whether the harmful impact of SDoH is mediated by stress is unknown. Moreover, the contributions of these factors has not been investigated in the context of a communal health crisis such as the COVID-19 pandemic. To examine these processes, we used a longitudinal cohort of 2473 women pregnant during the COVID-19 pandemic who reported a live birth. We compared structural equation models predicting gestational age at birth from SDoH (race/ethnicity, education, financial security, health insurance, relationship status, and lifetime abuse) and from prenatal maternal stress related and unrelated to the COVID-19 pandemic. Results indicate that the association of SDoH with earlier birth was partially mediated by prenatal stress. These findings help uncover mechanisms explaining health disparities in the U.S. and highlight the need to address both SDoH and the stress that these factors produce in under-resourced and marginalized communities.     

Food word processing in Chinese reading: A study of restrained eaters

Food-related attentional bias refers that individuals typically prioritize rewarding food-related cues (e.g. food words and food images) compared with non-food stimuli; however, the findings are inconsistent for restrained eaters. Traditional paradigms used to test food-related attentional bias, such as visual probe tasks and visual search tasks, may not directly and accurately enough to reflect individuals' food-word processing at different cognitive stages. In this study, we introduced the boundary paradigm to investigate food-word attentional bias for both restrained and unrestrained eaters. Eye movements were recorded when they performed a naturalistic sentence-reading task. The results of later-stage analyses showed that food words were fixated on for less time than non-food words, which indicated a superiority of foveal food-word processing for both restrained and unrestrained eaters. The results of early-stage analyses showed that restrained eaters spent more time on pre-target regions in the food-word valid preview conditions, which indicated a parafoveal food-word processing superiority for restrained eaters (i.e. the parafoveal-on-foveal effect). The superiority of foveal food-word processing provides new insights into explaining food-related attentional bias in general groups. Additionally, the enhanced food-word attentional bias in parafoveal processing for restrained eaters illustrates the importance of individual characteristics in studying word recognition.