Galpha(i2) inhibition of adenylate cyclase regulates presynaptic activity and unmasks cGMP-dependent long-term depression at Schaffer collateral-CA1 hippocampal synapses

Cyclic AMP signaling plays a central role in regulating activity at a number of synapses in the brain. We showed previously that pairing activation of receptors that inhibit adenylate cyclase (AC) and reduce the concentration of cyclic AMP, with elevation of the concentration of cyclic GMP is sufficient to elicit a presynaptically expressed form of LTD at Schaffer collateral-CA1 synapses in the hippocampus. To directly test the role of AC inhibition and G-protein signaling in LTD at these synapses, we utilized transgenic mice that express a mutant, constitutively active inhibitory G protein, Galpha(i2), in principal neurons of the forebrain. Transgene expression of Galpha(i2) markedly enhanced LTD and impaired late-phase LTP at Schaffer collateral synapses, with no associated differences in input/output relations, paired-pulse facilitation, or NMDA receptor-gated conductances. When paired with application of a type V phosphodiesterase inhibitor to elevate the concentration of intracellular cyclic GMP, constitutively active Galpha(i2) expression converted the transient depression normally caused by this treatment to an LTD that persisted after the drug was washed out. Moreover, this effect could be mimicked in control slices by pairing type V phosphodiesterase inhibitor application with application of a PKA inhibitor. Electrophysiological recordings of spontaneous excitatory postsynaptic currents and two-photon visualization of vesicular release using FM1-43 revealed that constitutively active Galpha(i2) tonically reduced basal release probability from the rapidly recycling vesicle pool of Schaffer collateral terminals. Our findings support the hypothesis that inhibitory G-protein signaling acts presynaptically to regulate release, and, when paired with elevations in the concentration of cyclic GMP, converts a transient cyclic GMP-induced depression into a long-lasting decrease in release.     

感知价值、满意度与继续使用意向—基于3G用户的实证研究

本文考察感知价值、满意度对继续使用意向的作用机理。基于相关理论与实证研究,我们首先提出3G用户继续使用意向概念模型与研究假设,然后通过实证研究对假设进行检验。研究结果表明感知价值和满意度决定继续使用意向。满意度是继续使用意向最强的预测因子。感知有用性和感知使用成本既直接作用于继续使用意向,也通过满意度间接作用于继续使用意向。感知易用性和感知形象提升直接作用于继续使用意向,而不需要通过满意度的中介作用。     

运动员咀嚼口香糖行为与竞赛焦虑的关系

为考察运动员咀嚼口香糖行为与竞赛焦虑的关系,本研究采用自编《咀嚼口香糖与竞赛焦虑问卷CGSCA》与《运动竞赛焦虑测验SCAT》,调查了457名运动员。结果发现,SCAT表明,运动员在竞赛情景下普遍处于应激状态并容易体验到焦虑;CGSCA表明,竞赛咀嚼行为与竞赛焦虑存在显著正相关,竞赛焦虑高的个体拥有更多的竞赛咀嚼行为,并更多地采用咀嚼口香糖的方式来缓解竞赛焦虑。本研究表明,咀嚼口香糖可以缓解运动员的竞赛焦虑。     

运用沙箱游戏区分自闭症谱系障碍儿童功能的可行性探索

摘 要： 通过沙箱作品来解读研究对象的内心世界是为常见,然根据其作品来区分自闭症谱系障碍（ASD）儿童功能的研究尚少,本研究力图为此进行探索。通过对126名已有医院诊断书的3.2~14岁ASD儿童的沙箱游戏行为、微缩玩具摆放过程观察及作品分析发现,ASD儿童功能越高,其沙箱游戏总分和沙箱游戏各观察维度的得分也越高,差异显著性均达到p<.001。ASD儿童功能越高,其沙箱作品的整合性、空间布局和想象力水平也越高。运用沙箱游戏或可区分ASD儿童的功能。     

闯入性思维对网络成瘾的影响:一个有调节的中介模型

本研究基于有限自制力理论考察闯入性思维对网络成瘾的影响及自我控制的中介作用和认知重评的调节作用。以371名大学生为被试,采用闯入性思维量表、自我控制量表、认知重评量表和网络成瘾量表进行测试,结果发现:(1)闯入性思维和自我控制呈显著负相关,与网络成瘾呈显著正相关;自我控制与网络成瘾呈显著负相关。(2)闯入性思维通过自我控制的中介作用对网络成瘾产生影响。(3)“闯入性思维—自我控制—网络成瘾”这一中介效应的前半段受到认知重评的影响;与低认知重评的个体相比,闯入性思维对高认知重评个体自我控制的影响更小。表达抑制不能调节闯入性思维对自我控制的影响。本研究的结果表明,闯入性思维会通过降低自我控制来增加网络成瘾的风险,而且认知重评会削弱闯入性思维对自我控制的影响。     

The development of children's preferences for equality and equity across 13 individualistic and collectivist cultures

A concern for fairness is a fundamental and universal element of morality. To examine the extent to which cultural norms are integrated into fairness cognitions and influence social preferences regarding equality and equity, a large sample of children (N 2,163) aged 4–11 were tested in 13 diverse countries. Children participated in three versions of a third‐party, contextualized distributive justice game between two hypothetical recipients differing in terms of wealth, merit, and empathy. Social decision‐making in these games revealed universal age‐related shifts from equality‐based to equity‐based distribution motivations across cultures. However, differences in levels of individualism and collectivism between the 13 countries predicted the age and extent to which children favor equity in each condition. Children from the most individualistic cultures endorsed equitable distributions to a greater degree than children from more collectivist cultures when recipients differed in regards to wealth and merit. However, in an empathy context where recipients differed in injury, children from the most collectivist cultures exhibited greater preferences to distribute resource equitably compared to children from more individualistic cultures. Children from the more individualistic cultures also favored equitable distributions at an earlier age than children from more collectivist cultures overall. These results demonstrate aspects of both cross‐cultural similarity and divergence in the development of fairness preferences.     

忠诚还是叛逆?中国组织情境下的员工越轨创新行为

越轨创新行为是破除创新瓶颈, 摆脱“创新者的窘境”的有效手段, 是新时代创新的重要途径。目的的合理性和行为的偏离性, 使越轨创新行为同时具有了“忠诚”和“叛逆”的色彩。以越轨创新究竟是“忠诚”还是“叛逆”这一问题作为切入点, 分别从越轨创新行为的测量、形成机制和影响效能角度构建了一个围绕越轨创新行为的系统性研究。子研究1：基于创新过程视角, 探讨中国组织情境下越轨创新行为的结构维度, 开发本土化量表。子研究2：分别从个体、领导和组织三个层次、动态探讨越轨创新行为的形成机制。子研究3：基于事件系统理论, 从越轨创新成功/失败两方面, 构建和验证越轨创新行为对组织效能的影响机制。三个子研究相互联系并逐步递进。理论贡献在于深化学术界对越轨创新行为的理解, 推动越轨创新理论的构建, 并且拓展越轨理论、创新理论、积极组织行为学理论及事件系统理论的应用。     

Person–city personality fit and entrepreneurial success: An explorative study in China

While the study of personality differences is a traditional psychological approach in entrepreneurship research, economic research directs attention towards the entrepreneurial ecosystems in which entrepreneurial activity are embedded. We combine both approaches and quantify the interplay between the individual personality make‐up of entrepreneurs and the local personality composition of ecosystems, with a special focus on person–city personality fit. Specifically, we analyse personality data from N = 26,405 Chinese residents across 42 major Chinese cities, including N = 1091 Chinese entrepreneurs. Multi‐level polynomial regression and response surface plots revealed that: (a) individual‐level conscientiousness had a positive effect and individual‐level agreeableness and neuroticism had a negative effect on entrepreneurial success, (b) city‐level conscientiousness had a positive, and city‐level neuroticism had a negative effect on entrepreneurial success, and (c) additional person–city personality fit effects existed for agreeableness, conscientiousness and neuroticism. For example, entrepreneurs who are high in agreeableness and conduct their business in a city with a low agreeableness level show the lowest entrepreneurial success. In contrast, entrepreneurs who are low in agreeableness and conduct their business in a city with a high agreeableness level show relatively high entrepreneurial success. Implications for research and practice are discussed.     

Violent video games exposure and aggression: The role of moral disengagement,anger, hostility,and disinhibition

Based on the General Aggression Model (GAM), the current study investigated the interactive effect of personal factors (e.g., sensation-seeking) and situational factors (e.g., violent video games exposure [VVGE]) on the trait aggressive behavior, and the mediating role of individual difference trait (e.g., moral disengagement, anger, and hostility). We recruited 547 undergraduates (48.45% male) from five Chinese universities. The results showed that VVGE was positively associated with moral disengagement, disinhibition, and the four aggressive traits (physical aggression, verbal aggression, anger, and hostility), which were positively associated with each other. Moral disengagement was positively associated with both the disinhibition and the four aggressive traits. Disinhibition was positively associated with the four aggressive traits as well. When controlled for gender, moral disengagement, anger, and hostility wholly mediated the relationship between VVGE and aggression, but the moderation effect of disinhibition was not significant. These findings support the framework of GAM and indicate that moral disengagement, anger, and hostility may be the factors that increase the risk of a higher level of aggression following repeated exposure to violent video games.     

知觉冲突信息对他人印象控制策略的影响:以直接信息与间接信息为例

个体根据知觉选择、反应偏向以及实时更新的情境信息调节自身状态,以适应性地促进对当前知觉信息的灵活编码,这一过程即为印象形成的认知控制。采用词语判断任务操控直接信息与间接信息,通过侧抑制任务的变式对知觉对象进行高、低负载两种水平的加工,考察了不同类型的冲突信息及其知觉负载对他人印象控制策略的影响。结果发现:知觉负载对印象控制策略的调节作用会依据知觉信息的类型(冲突vs.相容)而变化。具体而言,当知觉信息相容时,个体的印象控制策略仅受知觉负载的调节而产生效应,即高知觉负载的个体易采取主动性控制策略而进行自上而下的线索驱动性加工,低知觉负载的个体则易采取反应性控制策略而进行自下而上的探测驱动性加工; 当知觉信息冲突时,个体的知觉负载效应消失,即对冲突信息的印象控制策略受到知觉信息的类型(冲突vs.相容)与知觉负载双重调节:高知觉负载的个体易采取反应性控制策略而激活反刻板印象,从而在印象加工中出现冲突适应偏向; 低知觉负载的个体则易采取主动性控制策略而激活刻板印象,从而在印象加工中出现冲突抑制偏向。这些结果表明,仅当他人信息不存在冲突时,知觉负载对印象控制策略的调节才发挥单一效应。