Rheumatoid arthritis is associated with negatively variable impacts on domains of female sexual function: evidence from a systematic review and meta-analysis

To systematically review the literature to identify the impact of rheumatoid arthritis (RA) on specific female sexual function domains. A meta-analysis was performed and the related literature were searched in MEDLINE, EMBASE, Cochrane Library, CNKI, CBM and Web of Science databases, and in reference lists of articles and systematic reviews. Score of the Female Sexual Function Index (FSFI) was used as the outcome measurement, and mean differences (MD) with 95% confidence intervals (CI) were calculated. Five studies were included, including 346 women with RA and 237 healthy female controls. Each domain of the FSFI score: lubrication (MD, ?2.48; 95% CI, ?3.69, ?1.28), orgasm-1.71 (?2.09, ?1.33), sexual desire-1.27 (?1.59, ?0.95), satisfaction-1.67 (?2.18, ?1.16), arousal-1.83 (?2.85, ?0.82), pain-1.57 (?2.43, ?0.70) and the total score ?8.84 (?11.88, ?5.79) were lower in RA women than healthy controls. Furthermore, lubrication dimension was most severely affected especially. This meta-analysis showed that female RA patients scored lower in each dimension of FSFI, mostly in the lubrication domain. It demonstrated that targeted interventions should be done to improve their sexual function. Future well-designed researches with larger sample sizes are necessary to evaluate the potential risk factors which determine female sexual dysfunction.     

Association between cognitive vulnerability to depression - dysfunctional attitudes and glycaemic control among in-patients with type 2 diabetes in a hospital in Beijing: a multivariate regression analysis

This cross-sectional study aimed to investigate the relationship between glycosylated haemoglobin (HbA1c) and cognitive vulnerability to depression (dysfunctional attitudes) in patients with type 2 diabetes mellitus. A total of 245 valid records from June 2016 to December 2016 were collected from a hospital in Beijing. Participants were asked to complete four questionnaires (Dysfunctional Attitudes Scale, Automatic Thoughts Questionnaire, Zung Self-rating Depression Scale, and World Health Organization Quality of Life Instrument-Short Form) to assess mental health and quality of life. Multivariate regression analysis was conducted to determine the correlations between HbA1c, mental health, quality of life and other clinical variables. The results showed that dysfunctional attitudes were associated with HbA1c, with a standardized regression coefficient (β) of .13 (p = .01), although 1 h C-peptide (β = ?.75, p < .0001) was the most significant predictor of HbA1c in the regression model. The results indicated that dysfunctional attitudes, as a cognitive vulnerability to depression, were a relevant factor in HbA1c, although further studies are needed to establish the nature of the connection between dysfunctional attitudes and glycaemic control in diabetes patients.     

Training and transfer effects of response inhibition training in children and adults

Response inhibition is crucial for mental and physical health but studies assessing the trainability of this type of inhibition are rare. Thirty‐nine children aged 10‐12 years and 46 adults aged 18‐24 years were assigned to an adaptive go/no‐go inhibition training condition or an active control condition. Transfer of training effects to performance on tasks assessing response inhibition, interference control, working memory updating, task‐switching, and non‐verbal fluid intelligence were assessed during 3‐ and 6‐month follow‐up sessions and/or an immediate post‐training session. Significant training improvements and positive transfer effects to a similar response inhibition task with other stimuli were observed for both children and adults. Reliable albeit short‐lived transfer effects were only found for the children, specifically to working memory updating and task switching. These results suggest some potential for response‐inhibition training programs to enhance aspects of cognitive functioning in children but not adults.     

Vocabulary growth rate from preschool to school‐age years is reflected in the connectivity of the arcuate fasciculus in 14‐year‐old children

The acquisition of language involves the functional specialization of several cortical regions. Connectivity between these brain regions may also change with the development of language. Various studies have demonstrated that the arcuate fasciculus was essential for language function. Vocabulary learning is one of the most important skills in language acquisition. In the present longitudinal study, we explored the influence of vocabulary development on the anatomical properties of the arcuate fasciculus. Seventy‐nine Chinese children participated in this study. Between age 4 and age 10, they were administered the same vocabulary task repeatedly. Following a previous study, children's vocabulary developmental trajectories were clustered into three subgroups (consistently good, catch‐up, consistently poor). At age 14, diffusion tensor imaging data were collected. Using ROI‐based tractography, the anterior, posterior and direct segments of the bilateral arcuate fasciculus were delineated in each child's native space. Group comparisons showed a significantly reduced fractional anisotropy in the left arcuate fasciculus of children in the consistently poor group, in particular in the posterior and direct segments of the arcuate fasciculus. No group differences were observed in the right hemisphere, nor in the left anterior segment. Further regression analyses showed that the rate of vocabulary development, rather than the initial vocabulary size, was a specific predictor of the left arcuate fasciculus connectivity.     

Effect of achievement motivation on cognitive control adaptations

Previous research addressing motivational effects on cognitive control adaptations primarily manipulated external rewards. In the present study, we examined whether achievement motivation, reflecting intrinsic motivation, modulates cognitive control adaptations. In each of two experiments, students were divided into a high achievement motivation group (HAM; Experiment 1: N?=?36; Experiment 2: N?=?39) and a low achievement motivation group (LAM; Experiment 1: N?=?30; Experiment 2: N?=?39) on the basis of the Achievement Motivation Scale. Cognitive control adaptations were assessed by sequential congruency effects (SCEs) in Flanker tasks. Using a standard Flanker task in Experiment 1 and examining response times, the HAM but not LAM participants showed evidence of cognitive control adaptations. Because SCEs in a standard Flanker task may reflect lower-level, bottom-up processes rather than cognitive control adaptations, we used an adapted version of the Flanker task in Experiment 2 that controlled for the potential influence of such processes. Experiment 2 again revealed evidence of SCEs in the HAM but not LAM participants. These results suggest that cognitive control adaptions may be modulated by achievement motivation. Such potential modulation could be taken into account when evaluating results of previous and future fundamental and applied studies on cognitive control adaptations.     

基于认知设计系统的几何类比推理测验的编制及认知模型分析

认知诊断是一种新的测量范式。本研究首先根据Mulholland,Pellegrino＆Glaser和Whitely＆Schneider关于类比推理的研究结果,采用认知设计系统编制了几何类比推理测试题,并对所编制的测试题的质量进行验证,然后采用口语报告法分析解决几何类比推理所涉及的认知模型,结果表明：1）编制的几何类比推理测试题的质量比较好;2）学生解决类比推理所涉及的认知属性主要为置换、翻转、旋转、数量、大小、颜色与条纹和形状。     

Emotional reactions to scandals: When does moral character make a difference?

A scandal can evoke public outrage when it is widely publicized and involves an individual who is perceived to have a high level of cultural representativeness. Two experiments showed that when the scandalous target's moral character was highlighted, emotional responses towards the target were least negative when the scandal was widely circulated and when the target was seen as a representative of his culture. These results suggest that when a cultural symbol is implicated in a widely‐circulated scandal, the negative emotions directed towards the scandalous individual can be alleviated when the public remains confident in his or her commitment to morality.     

Contextual self-organizing map: software for constructing semantic representations

In this article, we introduce a software package that applies a corpus-based algorithm to derive semantic representations of words. The algorithm relies on analyses of contextual information extracted from a text corpus—specifically, analyses of word co-occurrences in a large-scale electronic database of text. Here, a target word is represented as the combination of the average of all words preceding the target and all words following it in a text corpus. The semantic representation of the target words can be further processed by a self-organizing map (SOM; Kohonen, Self-organizing maps, 2001), an unsupervised neural network model that provides efficient data extraction and representation. Due to its topography-preserving features, the SOM projects the statistical structure of the context onto a 2-D space, such that words with similar meanings cluster together, forming groups that correspond to lexically meaningful categories. Such a representation system has its applications in a variety of contexts, including computational modeling of language acquisition and processing. In this report, we present specific examples from two languages (English and Chinese) to demonstrate how the method is applied to extract the semantic representations of words.     

Deficits in early-stage face perception in excessive internet users

Excessive Internet use is associated with a limited ability to communicate effectively socially, which depends largely on the capacity for perception of the human face. We used a passive visual detection paradigm to compare the early stages of the processing of face-related information in young excessive Internet users (EIUs) and healthy normal subjects by analyzing event-related potentials (ERPs) elicited by faces and by nonface stimuli (tables), each presented in the upright and inverted position. The P1 and N170 components of the spectrum of ERPs elicited at occipital-temporal sites by the viewing of faces were larger and peaked sooner than the same ERP components elicited by tables, and inverted faces significantly enhanced and delayed the N170 component. EIUs had a generally smaller P1 component than did normal subjects, whether elicited by faces or by tables, and the N170 effect, or difference in amplitude of the N170 component for faces versus tables, was significantly smaller in the EIUs than in normal subjects. However, the N170 inversion effect, or difference in amplitude of the N170 component elicited by upright versus inverted faces, was similar in the EIUs and normal subjects. These data indicate that EIUs have deficits in the early stage of face-perception processing but may have intact holistic/configural processing of faces. Whether some deeper processes of face perception, such as face memory and face identification, are affected in EIUs needs to be investigated further with more specific procedures.     

Two components in IOR: evidence for response bias and perceptual processing delays using the SAT methodology

Inhibition of return (IOR) occurs when reaction times (RTs) are slowed to respond to a target that appears at a previously attended location. We used the speed-accuracy trade-off (SAT) procedure to obtain conjoint measures of IOR on sensitivity and processing speed by presenting targets at cued and uncued locations. The results showed that IOR is associated with both delays in processing speed and shifts in response criterion. When the target was briefly presented, the results supported a criterion shift account of IOR. However, when the target was presented until response, the evidence indicated that, in addition to a response bias effect, there was an increase in the minimal time required for information about the target to accumulate above chance level. A hybrid account of IOR is suggested that describes effects on both response bias and perceptual processing.