Contingent attentional capture by top-down control settings: converging evidence from event-related potentials

Theories of attentional control are divided over whether the capture of spatial attention depends primarily on stimulus salience or is contingent on attentional control settings induced by task demands. The authors addressed this issue using the N2-posterior- contralateral (N2pc) effect, a component of the event-related brain potential thought to reflect attentional allocation. They presented a cue display followed by a target display of 4 letters. Each display contained a green item and a red item. Some participants responded to the red letter and others to the green letter. Converging lines of evidence indicated that attention was captured by the cues with the same color as the target. First, these target-color cues produced a cuing validity effect on behavioral measures. Second, distractors appearing in the cued location produced larger compatibility effects. Third, the target-color cue produced a robust N2pc effect, similar in magnitude to the N2pc effect to the target itself. Furthermore, the target-color cue elicited a similar N2pc effect regardless of whether it competed with a simultaneous abrupt onset. The findings provide converging evidence for attentional capture contingent on top-down control settings.     

Response Style Differences in the Inattentive and Combined Subtypes of Attention-Deficit/Hyperactivity Disorder

This study examined potential differences between the inattentive and combined ADHD subtypes using laboratory tasks assessing behavioral inhibitory processes. Seventy-five children completed two tasks of behavioral inhibition believed to isolate different processes: the cued reaction time task (CRT), a basic inhibition task, and the go/no-go task (GNG), a complex inhibition task that incorporates motivational contingencies. Three groups of participants were identified, including ADHD/Inattentive (n = 17), ADHD/Combined (n = 37), and comparison (n = 21). Results indicated that rather than showing behavioral inhibition deficits, the ADHD/I children appeared overly inhibited, as evidenced by slower reaction times across the two tasks and significantly higher errors of omission in the GNG task. Additionally, the ADHD/I children did not demonstrate cue dependency effects on the CRT task, suggesting that they were failing to incorporate relevant information before making a response. The sluggish and inhibited performance of the ADHD/I group challenges the idea that it is a subtype of ADHD.     

Self-Report Measures of Individual Differences in Regulatory Focus: A Cautionary Note

Regulatory focus theory distinguishes between two independent structures of strategic inclination, promotion versus prevention. However, the theory implies two potentially independent definitions of these inclinations, the self-guide versus the reference-point definitions. Two scales (the Regulatory Focus Questionnaire, Higgins al., 2001, and the General Regulatory Focus Measure, Lockwood, Jordan, & Kunda, 2002) have been widely used to measure dispositional regulatory focus. We suggest that these two scales align respectively with the two definitions, and find that the two scales are largely uncorrelated. Both conceptual and methodological implications are discussed.     

Why Do People Join Groups? Three Motivational Accounts from Social Psychology

This paper describes and contrasts three contemporary social psychological theories that focus on why people join and identify with groups: the sociometer model, terror management theory, and uncertainty–identity theory. The sociometer model argues that people have a need to be socially included, and that self‐esteem is a meter of successful inclusion and group belonging. Terror management theory argues that people are motivated to reduce fear of the inevitability of their own death, and that the consensual belief–confirmation provided by groups drives people to belong. Uncertainty–identity theory argues that people have a basic need to reduce uncertainty about themselves, their attributes, and their place in the world, and that cognitive processes associated with group identification reduce such uncertainty. We critically contrast these three accounts to conclude that all three motivational processes may play a role, but that self‐uncertainty may have the benefit of wide generality to all groups and group contexts and of detailed specification of cognitive processes.     

Treatment outcomes for female offenders: relationship to number of Axis I diagnoses

This article describes a study that examined the relationship between multiple Axis I mental health diagnoses and treatment outcomes for female offenders in prison substance abuse treatment programs. Preliminary findings of the effectiveness of therapeutic community (TC) treatment, modified for female offenders, relative to a control cognitive behavioral treatment condition, are presented. The hypothesis--that participants who fit into multiple diagnostic categories have more dysfunctional symptoms and behaviors at baseline--was confirmed; however, a hypothesized relationship between the number of Axis I diagnoses and 6 month treatment outcomes across five domains (mental health, trauma exposure, substance use, HIV needle risk behaviors, and HIV sexual risk) was not supported. Across all Axis I mental health groups, TC treatment was significantly more effective than the control condition overall, as well as on measures of mental health symptoms and HIV sexual risk. These findings suggest that this TC treatment program, as modified, is an effective model for women with varied diagnoses and diagnostic complexities.     

Beta-adrenergic receptor activation during distinct patterns of stimulation critically modulates the PKA-dependence of LTP in the mouse hippocampus

Activation of β-adrenergic receptors (β-ARs) enhances hippocampal memory consolidation and long-term potentiation (LTP), a likely mechanism for memory storage. One signaling pathway linked to β-AR activation is the cAMP-PKA pathway. PKA is critical for the consolidation of hippocampal long-term memory and for the expression of some forms of long-lasting hippocampal LTP. How does β-AR activation affect the PKA-dependence, and persistence, of LTP elicited by distinct stimulation frequencies? Here, we use in vitro electrophysiology to show that patterns of stimulation determine the temporal phase of LTP affected by β-AR activation. In addition, only specific patterns of stimulation recruit PKA-dependent LTP following β-AR activation. Impairments of PKA-dependent LTP maintenance generated by pharmacologic or genetic deficiency of PKA activity are also abolished by concurrent activation of β-ARs. Taken together, our data show that, depending on patterns of synaptic stimulation, activation of β-ARs can gate the PKA-dependence and persistence of synaptic plasticity. We suggest that this may allow neuromodulatory receptors to fine-tune neural information processing to meet the demands imposed by numerous synaptic activity profiles. This is a form of “metaplasticity” that could control the efficacy of consolidation of hippocampal long-term memories.The hippocampus importantly contributes to memory function in the mammalian brain (Zola-Morgan et al. 1986; Eichenbaum et al. 1990; Otto and Eichenbaum 1992; Phillips and LeDoux 1992; Remondes and Schuman 2004). It has reciprocal connections with numerous cortical areas, including those responsible for high-level integration of spatial and contextual data from the external environment (Lavenex and Amaral 2000). As such, the hippocampus is well positioned to receive and survey a broad range of information and select behaviorally salient data for long-term storage. Activity-dependent enhancement of hippocampal synaptic strength can store information carried in patterns of afferent neural activity (Bliss and Collingridge 1993; Moser et al. 1998; Nathe and Frank 2003; Whitlock et al. 2006). Substantial evidence suggests that long-term potentiation (LTP) of synaptic strength plays important roles in the formation of long-term memory (LTM) (Doyere and Laroche 1992; Bourtchuladze et al. 1994; Abel and Lattal 2001; Genoux et al. 2002). As such, mechanistic studies of LTP have shed valuable light on how the mammalian brain stores new information.The hippocampus receives dense noradrenergic projections from the locus coeruleus, a brain structure that can influence many vital brain functions, including attention, sleep, arousal, mood regulation, learning, and memory (Berridge and Waterhouse 2003). Both α- and β-adrenergic receptor subtypes are present on hippocampal neurons (Morrison and Foote 1986; Berridge and Waterhouse 2003), and noradrenaline (NA) acts on hippocampal β-adrenergic receptors (β-ARs) to facilitate the retention and recall of memory (Izquierdo et al. 1998; Ji et al. 2003; Murchison et al. 2004). In humans, stimulation of the noradrenergic neuromodulatory system enhances memory for emotional stimuli, and inhibition of β-ARs prevents this memory enhancement (Cahill et al. 1994; van Stegeren et al. 1998; O’Carroll et al. 1999).Consistent with the notion that selective enhancement of LTM may occur following β-AR activation, stimulation of β-ARs can also facilitate the persistence of LTP. In areas CA3 and CA1, β-AR activation facilitates the induction of long-lasting LTP when paired with certain patterns of electrical stimulation (Huang and Kandel 1996; Gelinas and Nguyen 2005). However, the mechanisms by which different patterns of stimulation control synaptic responsiveness to β-AR activation are unclear.β-ARs couple to guanine-nucleotide-binding regulatory Gs proteins to stimulate adenylyl cyclase activity and increase intracellular cAMP (Seeds and Gilman 1971; Maguire et al. 1977). A main target of cAMP signaling is activation of cAMP-dependent protein kinase (PKA), a kinase that is required for some forms of long-lasting LTP and for consolidation of hippocampal LTM (Frey et al. 1993; Abel et al. 1997; Nguyen and Woo 2003). Interestingly, the PKA-dependence of hippocampal LTP displays plasticity: Specific temporal patterns of synaptic stimulation, such as repeated and temporally spaced 100-Hz stimulation, elicit LTP that requires PKA for its expression (Woo et al. 2003). Also, spatial “enrichment” can increase the PKA-dependence of LTP in mice, and this is correlated with improved hippocampal memory function (Duffy et al. 2001). However, it is unclear whether activation of β-ARs can critically gate the PKA-dependence of LTP. In this study, we examine the effects of β-AR activation on LTP generated by various patterns of afferent stimulation in area CA1 of the hippocampus, and we determine the role of PKA in these β-AR-modulated forms of LTP.     

Basic Self-Knowledge: Answering Peacocke’s Criticisms of Constitutivism

Constitutivist accounts of self-knowledge argue that a noncontingent, conceptual relation holds between our first-order mental states and our introspective awareness of them. I explicate a constitutivist account of our knowledge of our own beliefs and defend it against criticisms recently raised by Christopher Peacocke. According to Peacocke, constitutivism says that our second-order introspective beliefs are groundless. I show that Peacocke’s arguments apply to reliabilism not to constitutivism per se, and that by adopting a functionalist account of direct accessibility a constitutivist can avoid reliabilism. I then argue that the resulting view is preferable to Peacocke’s own account of self-knowledge.     

Adolescent perceptions of overall family system functioning and parental behaviors

We used a systems perspective to examine relationships between adolescents’ perceptions of overall family system functioning and selected parental behaviors. Self-report questionnaire data from 160 ninth and tenth grade students were analyzed using MANCOVA and discriminant analysis. The results showed two parental behaviors, support and monitoring distinguished between types of overall family system functioning. Adolescents in balanced and moderately balanced overall family functioning reported greater parental support, while adolescents in balanced and extreme overall family functioning reported greater parental monitoring. We present the implications of our findings for parent education and assessment.