人工肝支持系统治疗肝衰竭的研究进展

目前肝衰竭发病率和病死率仍然较高,肝衰竭成为威胁患者生命的严重疾病。基于肝脏具有强大再生能力,人工肝支持系统作为一种“过渡”措施,为肝衰竭患者的肝功能恢复赢得时间。人工肝支持系统根据性质不同分为非生物型人工肝、生物型人工肝和混合型人工肝。目前非生物型人工肝已在肝病治疗领域被广泛应用,但生物型及混合型人工肝的临床应用还存在很多问题需要进一步研究和解决。因此本文对人工肝的作用、临床应用现状、存在问题及研究进展进行综述。     

Development and Pilot Testing of a Decision Aid for Genomic Research Participants Notified of Clinically Actionable Research Findings for Cancer Risk

Germline genomic testing is increasingly used in research to identify genetic causes of disease, including cancer. However, there is evidence that individuals who are notified of clinically actionable research findings have difficulty making informed decisions regarding uptake of genetic counseling for these findings. This study aimed to produce and pilot test a decision aid to assist participants in genomic research studies who are notified of clinically actionable research findings to make informed choices regarding uptake of genetic counseling. Development was guided by published literature, the International Patient Decision Aid Standards, and the expertise of a steering committee of clinicians, researchers, and consumers. Decision aid acceptability was assessed by self-report questionnaire. All 19 participants stated that the decision aid was easy to read, clearly presented, increased their understanding of the implications of taking up research findings, and would be helpful in decision-making. While low to moderate levels of distress/worry were reported after reading the booklet, a majority of participants also reported feeling reassured. All participants would recommend the booklet to others considering uptake of clinically actionable research findings. Results indicate the decision aid is acceptable to the target audience, with potential as a useful decision support tool for genomic research participants.     

农村留守儿童焦虑情绪的异质性:基于潜在剖面分析

采用中学生心理健康诊断量表（MHT）对湖南省1292名留守儿童的焦虑情绪进行施测,并用潜在剖面分析方法探究留守儿童的焦虑情绪问题是否存在异质性,以及留守儿童相关的人口学因素对焦虑情绪异质性的作用机制。结果发现,留守儿童的焦虑情绪存在明显的异质性,可以分为三种潜在类别：“严重焦虑情绪型”、“中等程度焦虑情绪型”和“低焦虑情绪型”;留守男生、小学五年级、高中二年级、留守时间越长、留守初始年龄越小的留守儿童更容易焦虑情绪严重;无论是父亲外出、母亲外出还是双亲外出对留守儿童的焦虑情绪严重性的影响是一致的。由此,应根据留守儿童的性别、年级、留守时长和留守的初始年龄等情况特点,开展针对性的预防和干预措施,缓解留守儿童焦虑。     

父母情绪表达与青少年问题行为:亲子依恋、孤独感的多重中介效应

本研究以西安市两所中学的211名初一学生和477名高一学生共计688名学生为被试,探讨了父母情绪表达对青少年问题行为的影响,以及亲子依恋和孤独感在父母情绪表达与青少年问题行为间的中介作用,采用《父母情绪表达问卷》、《亲密关系体验量表》、《孤独感量表》、《青少年自评量表》进行测量研究。结果表明：父母情绪表达、亲子依恋、孤独感和青少年内、外化问题两两间存在显著相关;亲子依恋与孤独感在父母情绪表达与青少年问题行为间起多重中介作用,父母情绪表达既可直接影响青少年问题行为,也可以通过不安全依恋、孤独感各自独立的中介作用和不安全依恋、孤独感的链式中介作用影响青少年问题行为。本研究揭示了父母情绪表达与青少年问题行为的关系及其作用机制,拓展了父母情绪社会化对个体心理社会适应的研究。     

HIV prevention with persons with mental health problems

The HIV seroprevalence rate among persons with mental health problems (PMHP) is substantially higher than that of the general population in the United States. This study examines the efficacy over 12 months of an HIV prevention program with 99 individuals attending outpatient mental health clinics who were randomly assigned to receive either: (a) a seven-session, small-group intervention of Project LIGHT (Living in Good Health Together); or (b) a one-session video intervention. Regression analyses of data from 87% of the sample interviewed at 1-year follow-up revealed that intervention group membership was associated with significantly fewer sexual risk acts. A significant intervention effect for condom use was found for 72% of the sample who were African American, but not for Latino or Caucasian participants. Results from this study suggest that HIV risk reduction groups such as Project LIGHT may have utility in public mental health care settings.     

转基因技术安全性的生态伦理浅析

以转基因技术为基础的生物技术是本世纪最具影响力的高新技术产业带。转基因技术在农业、食品、医药、环保等方面有广泛应用,它给人类社会的发展带来巨大的经济效益和社会效益的同时,也存在着潜在危险,即有可能影响生态环境,危害人类健康。本文试图从生态伦理的角度来思考转基因技术的安全性问题。     

法理学视域下的医患法律关系属性

从法理学的角度来说,医患法律关系应该属于独立的医事法调整的对象,属于社会法法域.这一判断既有其理论依据又颇具实践价值:它能为订立独立的医事法提供理论基础,为运用多元化机制解决医疗纠纷提供理论支点,为构建和谐医患关系提供视角转换,即从“医—患”二维视角转换为“国—医—患—社”四维视角.     

Frontolimbic neural circuitry at 6 months predicts individual differences in joint attention at 9 months

Elucidating the neural basis of joint attention in infancy promises to yield important insights into the development of language and social cognition, and directly informs developmental models of autism. We describe a new method for evaluating responding to joint attention performance in infancy that highlights the 9‐ to 10‐month period as a time interval of maximal individual differences. We then demonstrate that fractional anisotropy in the right uncinate fasciculus, a white matter fiber bundle connecting the amygdala to the ventral‐medial prefrontal cortex and anterior temporal pole, measured in 6‐month‐olds predicts individual differences in responding to joint attention at 9 months of age. The white matter microstructure of the right uncinate was not related to receptive language ability at 9 months. These findings suggest that the development of core nonverbal social communication skills in infancy is largely supported by preceding developments within right lateralized frontotemporal brain systems.     

在押毒品犯人格的基本特征及其相关因素的研究

本研究以 3 78名在押毒品犯为被试 ,以CPI为测量工具 ,探讨了在押毒品犯的基本特征和类型特征 ,并采用方差分析技术研究了影响毒品犯人格的若干因素。结果发现 ,与对照组相比 ,在押毒品犯除了在“自我控制”分量表上未发现显著差异外 ,其余的 1 9个分量表上均有显著差异 ;在押毒品犯在四种人格类型上的分布不平衡 ,主要集中在Delta类型 ;年龄、关押时间对毒品犯的人格特征的变异有一定影响 ,而减刑次数的影响不显著