Amygdala activation to sad pictures during high-field (4 tesla) functional magnetic resonance imaging

Fear-related processing in the amygdala has been well documented, but its role in signaling other emotions remains controversial. The authors recovered signal loss in the amygdala at high-field strength using an inward spiral pulse sequence and probed its response to pictures varying in their degree of portrayed sadness. These pictures were presented as intermittent task-irrelevant distractors during a concurrent visual oddball task. Relative to neutral distractors, sad distractors elicited greater activation along ventral brain regions, including the amygdala, fusiform gyrus, and inferior frontal gyrus. In contrast, oddball targets engaged dorsal sectors of frontal, parietal, and cingulate cortices. The amygdala's role in emotional evaluation thus extends to images of grief and despair as well as to those depicting violence and threat.     

助推爱心：利用默认选项促进捐赠行为

本研究采用实验室和现场实验的方法检验了默认选项的助推策略是否能够促进慈善捐赠行为。结果发现：（1）相较于把被试费的“保留选项”设置为默认,把“捐献选项”设置为默认时,被试捐献的概率和金额更高;（2）在多个捐款选项情景中,默认选项的设置总体上提高了默认选项被选择的概率;将最大金额选项设置为默认选项有助于提高被试平均捐赠额。这些发现表明,应用默认选项的助推策略能够有效促进人们的捐赠行为。本研究结果对减少募捐成本、提高募捐效率有所启示。     

小学生心理素质与学业成绩的关系

运用《瑞文标准推理测验》和自编的《小学生心理素质问卷》对1247名小学生作心理素质团体测试。利用方差分析和聚类分析,探讨小学生心理素质与学业成绩的关系。结果表明:(1)总体上,学业成绩高分组心理素质优于学业成绩中等组和低分组,学业成绩中等组优于学业成绩低分组。(2)分年级看,不同年级不同学业成绩组的小学生在心理素质因素上的差异有不同。(3)学业成绩高分组学生主要分布在心理素质较好的水平层次,学业成绩中等组主要分布在心理素质中等水平层次上,而学业成绩低分组主要分布在心理素质不好的水平层次。     

Dietary ethyl-eicosapentaenoic acid but not soybean oil reverses central interleukin-1-induced changes in behavior, corticosterone and immune response in rats

Omega (n)-3 and n-6 fatty acids are important membrane components of neurons and immune cells, and related to psychiatric and inflammatory diseases. Increased ratio of n-6/n-3 in the blood has been reported in depressed patients and in students following stress exposure. The n-3 fatty acid, eicosapentaenoic acid (ethyl-EPA) suppresses inflammation and has antidepressant properties. Interleukin (IL)-1beta can stimulate corticosterone secretion, induce anxiety and stress-like behavior and inflammatory responses. This study was to evaluate the effect of diets enriched with coconut oil, ethyl-EPA and soybean oil on central IL-1beta induced stress and anxiety-like behavior, induced changes in the concentration of prostaglandin (PG) E2 and corticosterone and the release of IL-10. Groups of rats were fed with either 5% coconut oil (as control diet), 0.2% EPA with 4.8% coconut oil or 1% EPA with 4% coconut oil and 5% soybean oil for 7 weeks. The central administration of IL-1beta induced sickness, stress and anxiety-like behavior as indicated by a reduction in body weight, decreased time spent, and the number of entries, into the open arms of the elevated plus maze and decreased exploration and entry into the central zone of the "open field" apparatus. IL-1beta also increased PGE2 and corticosterone concentrations and decreased the release of IL-10 from leucocytes. Food enriched with ethyl-EPA but not soybean oil, significantly attenuated most of these changes. These results demonstrate that ethyl-EPA has anti-inflammatory, anti-stress and anti-anxiety effects in rats.     

Quality of life assessment in Turkish patients with schizophrenia and their relatives

Quality of life of first-degree relatives living in the same household with patients having schizophrenia has not been sufficiently explored. 30 patients with schizophrenia (16 women, 14 men), diagnosed using DSM-IV criteria, 31 of their relatives (15 women, 16 men), and 34 control subjects (21 women, 13 men) were included in the study. The mean age of the patients, their relatives, and the control subects were 39.8 +/- 10.9, 58.1 +/- 12.5 and 37.3 +/- 17.0, respectively. The World Health Oranization Quality of Life-Brief Form was administered to all subjects. Quality of life was worse for the patient group than for their relatives and control subjects, but relatives of the patients and control subjects were not significantly different on Quality of life. Quality of life was negatively correlated with the severity of psychopathology and extrapyramidal side effects induced by antipsychotic drugs in the patients.     

Model comparison of nonlinear structural equation models with fixed covariates

Recently, it has been recognized that the commonly used linear structural equation model is inadequate to deal with some complicated substantive theory. A new nonlinear structural equation model with fixed covariates is proposed in this article. A procedure, which utilizes the powerful path sampling for computing the Bayes factor, is developed for model comparison. In the implementation, the required random observations are simulated via a hybrid algorithm that combines the Gibbs sampler and the Metropolis-Hastings algorithm. It is shown that the proposed procedure is efficient and flexible; and it produces Bayesian estimates of the parameters, latent variables, and their highest posterior density intervals as by-products. Empirical performances of the proposed procedure such as sensitivity to prior inputs are illustrated by a simulation study and a real example.This research is fully supported by a grant from the Research Grant Council of the Hong Kong Special Administrative Region, China (Project No. CUHK 4346/01H). The authors are thankful to the Editor, the Associate Editor, and anonymous reviewers for valuable comments which improve the paper significantly, and grateful to ICPSR and the relevant funding agency for allowing use of the data in the example. The assistance of Michael K.H. Leung and Esther L.S. Tam is gratefully acknowledged.     

辩证分析兴奋性氨基酸对神经细胞的双重作用

兴奋性氨基酸（ＥＡＡｓ） 广泛分布于中枢神经系统,参与多种生理过程包括学习、记忆和伤害感受等。然而,ＥＡＡｓ 受体的过度兴奋却可引发一系列细胞事件,最终导致神经元的损伤与死亡。许多神经退行性疾病如早老性痴呆、癫痫和肌侧索硬化症等都与ＥＡＡｓ 的兴奋毒作用有关。目前的研究表明,由ＥＡＡｓ 受体过度兴奋所引发的细胞内钙超载是导致神经元死亡的最终途径     

王夫之“阴阳向背”说的本体意义

王夫之阴阳十二位向背是根据乾坤并建之体的性质及体用一源的原理引申、推论出来的,他用这一原理来批评象数学的机械排比和框定,并用事物的自然自足、自立自全的性质,证明《序卦传》的三种卦序说不能成立,为自己独特的卦序说奠立基础。他要证明的哲学原理是,显现有向背,阳阳无或缺;本体所具有的性质与功能,同时就具于个体之中,个体因此而有了主体性、能动性,和自由地独立活动的品格。     

限铁机制:人类与细菌间的一场龙争虎斗——解读女性月经之谜

通过介绍限铁机制的基本概念;铁螯合蛋白的功用;解释假性贫血的成因以及铁过剩的危害;推论认为女性月经失血是限铁机制的体现;人类限铁机制的强化包括女性月经失血水平的上升;是对人类抗坏血酸遗传缺陷的补救措施;验证了由自然选择推进的生殖最大化是适应的本质.