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831.
The hypothalamo-pituitary-adrenal (HPA) axis plays a major role in the regulation of responses to stress. Human stress-related disorders such as chronic fatigue syndrome (CFS), fibromyalgia syndrome (FMS), chronic pelvic pain and post-traumatic stress disorder are characterized by alterations in HPA axis activity. However, the role of the HPA axis alterations in these stress-related disorders is not clear. Most studies have shown that the HPA axis is underactive in the stress-related disorders, but contradictory results have also been reported, which may be due to the patients selected for the study, the methods used for the investigation of the HPA axis, the stage of the syndrome when the tests have been done and the interpretation of the results. There is no structural abnormality in the endocrine organs which comprise the HPA axis, thus it seems that hypocortisolemia found in the patients with stress-related disorder is functional. It may be also an adaptive response of the body to chronic stress. In this review, tests used in the assessment of HPA axis function and the HPA axis alterations found in CFS and FMS are discussed in detail.  相似文献   
832.
Hoarding behavior occurs frequently in obsessive-compulsive disorder (OCD). Results from previous studies suggest that individuals with OCD who have hoarding symptoms are clinically different than non-hoarders and may represent a distinct clinical group. In the present study, we compared 235 hoarding to 389 non-hoarding participants, all of whom had OCD, collected in the course of the OCD Collaborative Genetics Study. We found that, compared to non-hoarding individuals, hoarders were more likely to have symmetry obsessions and repeating, counting, and ordering compulsions; poorer insight; more severe illness; difficulty initiating or completing tasks; and indecision. Hoarders had a greater prevalence of social phobia and generalized anxiety disorder. Hoarders also had a greater prevalence of obsessive-compulsive and dependent personality disorders. Five personality traits were independently associated with hoarding: miserliness, preoccupation with details, difficulty making decisions, odd behavior or appearance, and magical thinking. Hoarding and indecision were more prevalent in the relatives of hoarding than of non-hoarding probands. Hoarding in relatives was associated with indecision in probands, independently of proband hoarding status. The findings suggest that hoarding behavior may help differentiate a distinct clinical subgroup of people with OCD and may aggregate in some OCD families. Indecision may be a risk factor for hoarding in these families.  相似文献   
833.
Change blindness is the name given to people's inability to detect changes introduced between two consecutively-presented scenes when they are separated by a distractor that masks the transients that are typically associated with change. Change blindness has been reported within vision, audition, and touch, but has never before been investigated when successive patterns are presented to different sensory modalities. In the study reported here, we investigated change detection performance when the two to-be-compared stimulus patterns were presented in the same sensory modality (i.e., both visual or both tactile) and when one stimulus pattern was tactile while the other was presented visually or vice versa. The two to-be-compared patterns were presented consecutively, separated by an empty interval, or else separated by a masked interval. In the latter case, the masked interval could either be tactile or visual. The first experiment investigated visual-tactile and tactile-visual change detection performance. The results showed that in the absence of masking, participants detected changes in position accurately, despite the fact that the two to-be-compared displays were presented in different sensory modalities. Furthermore, when a mask was presented between the two to-be-compared displays, crossmodal change blindness was elicited no matter whether the mask was visual or tactile. The results of two further experiments showed that performance was better overall in the unimodal (visual or tactile) conditions than in the crossmodal conditions. These results suggest that certain of the processes underlying change blindness are multisensory in nature. We discuss these findings in relation to recent claims regarding the crossmodal nature of spatial attention.  相似文献   
834.
Research examining the diathesis-stress component of the hopelessness theory (HT) in youth has provided mixed support for the theory. One explanation for inconsistent findings is the failure to consider relationships among the three inferential styles posited to serve as vulnerability factors by the theory. The weakest link hypothesis posits that an individual is as vulnerable to depression as his/her most depressogenic inferential style (DIS) makes him/her. A second explanation is that researchers have operationalized "high stress" from a nomothetic, as opposed to an idiographic, perspective. The current study tested the diathesis-stress component of the HT in 230 third-grade and 152 seventh-grade schoolchildren using both a weakest link and an idiographic approach towards analysis. Children completed measures assessing depressive symptoms and DISs. Children subsequently completed measures assessing depressive symptoms and negative events once a week for 6 weeks. Hierarchical linear modeling and time-lagged analyses indicated that a depressogenic weakest link was associated with greater elevations in depressive symptoms following elevations in stress.  相似文献   
835.
The current study examined whether neuroticism, emotional regulation deficits, and/or their interaction predict increased engagement in risky behaviors following increases in symptoms of depression or anxiety over the course of 6 weeks. Results of hierarchical linear modeling analyses indicated that individuals who exhibited high levels of both neuroticism and emotional regulation deficits were more likely than other individuals to report increased engagement in risky behaviors following increases in symptoms of either depression or anxiety. Unexpectedly, individuals who exhibited high levels of neuroticism and adaptive emotion regulation strategies exhibited decreased engagement in risky behaviors following increases in depressive or anxious symptoms.  相似文献   
836.
In 6 studies, the authors examined the perception of dominance complementarity, which is the perception of a target as different from the self in terms of dominance. The authors argue that these perceptions are motivated by the desire for positive task relationships. Because dominance complementarity bodes well for task-oriented relationships, seeing dominance complementarity allows one to be optimistic about a work relationship. As evidence that perceptions of dominance complementarity are an instance of motivated perception, the authors show that complementary perceptions occur when participants think about or expect task-oriented relationships with the target and that perceptions of dominance complementarity are enhanced when individuals care about the task component of the relationship.  相似文献   
837.
The phenomenon of change blindness (the surprising inability of people to correctly perceive changes between consecutively presented displays), primarily reported in vision, has recently been shown to occur for positional changes presented in tactile displays as well. Here, we studied people's ability to detect changes in the number of tactile stimuli in successively presented displays composed of one to three stimuli distributed over the body surface. In Experiment 1, a tactile mask consisting of the simultaneous activation of all seven possible tactile stimulators was sometimes presented between the two to-be-discriminated tactile displays. In Experiment 2, a "mudsplash" paradigm was used, with a brief irrelevant tactile distractor presented at the moment of change of the tactile display. Change blindness was demonstrated in both experiments, thus showing that the failure to detect tactile change is not necessarily related to (1) the physical disruption between consecutive events, (2) the effect of masking covering the location of the change, or (3) the erasure or resetting of the information contained within an internal representation of the tactile display. These results are interpreted in terms of a limitation in the number of spatial locations/events that can be consciously accessed at any one time. This limitation appears to constrain change-detection performance, no matter the sensory modality in which the stimuli are presented.  相似文献   
838.
Recent years have brought relativistic accounts of knowledge, first-person belief, and future contingents to prominence. I discuss these views, distinguish non-trivial from trivial forms of relativism, and then argue against relativism in all of its substantive varieties.  相似文献   
839.
Haptic interfaces are becoming more commonplace in virtual environment and teleoperation systems. There is a growing need to not only continue to improve hardware platforms and rendering algorithms, but evaluate human performance with haptic interfaces. This review summarizes two recent studies inspired by perception problems in using haptic interfaces to interact with virtual environments. The first study evaluated perceived quality of virtual haptic textures and discovered several types of perceived instability and their sources. We found that the buzzing type of perceived instability was most likely due to the mechanical resonance of the haptic interface hardware, and the aliveness type of perceived instability due to our inability to sense the slight movements of our hands in free space. The second study focused on the motor strategy employed during interaction with a virtual surface via a force-feedback haptic interface. We found that users tended to maintain a constant penetration force into a virtual surface when interacting with the surface. This can result in a reversal in perceived relative surface heights if the taller surface is rendered with a lower stiffness, thereby resulting in an erroneous perception of the virtual environment being rendered. For both studies, possible solutions to improving human perception of virtual and remote objects via hardware and/or software are discussed.  相似文献   
840.
Between-study comparisons of benzodiazepine and anticholinergic drugs on working memory suggest that anticholinergics may produce greater impairment in maintenance processes, whereas benzodiazepines may produce greater impairment in manipulation processes. This study directly compared acute effects of the benzodiazepine lorazepam (1.0 and 2.0 mg/70 kg, orally administered) and the anticholinergic scopolamine (0.25 and 0.50 mg/ 70 kg, subcutaneously administered) on working memory maintenance (storage and rehearsal) and manipulation processes in a placebo-controlled, double-dummy, double-blind, crossover design in 20 healthy volunteers. Using a modified Sternberg paradigm, storage, rehearsal, and manipulation processes were parametrically manipulated by varying memory load, delay between stimulus presentation and test, and number of operations performed on the letter strings, respectively, while controlling for drug effects on nonmemory processes. As predicted, the results suggested greater impairment in maintenance processes (rehearsal) with scopolamine than with lorazepam and greater impairment in manipulation processes with lorazepam than with scopolamine. In addition, the results suggested greater overall slowing of working memory processes with lorazepam.  相似文献   
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