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81.
Spatial learning in rats is impaired by microinfusions of protein kinase C-gamma antisense oligodeoxynucleotide within the nucleus accumbens 总被引:1,自引:0,他引:1
Alvarez-Jaimes L Betancourt E Centeno-González M Feliciano-Rivera MZ Rodríguez D Peña de Ortíz S Maldonado-Vlaar CS 《Neurobiology of learning and memory》2004,81(2):120-136
The nucleus accumbens (NAcc) has been shown to play a role in motor and spatial learning. Protein kinase C (PKC) has been implicated in the mechanisms of initiation and maintenance of long-term potentiation that is thought to be involved in the storage of long-term memory. In the present study, the importance of de novo synthesis of PKC-gamma within the NAcc in the acquisition and retention of spatial discrimination learning was assessed using an antisense knockdown approach. Separate groups of Long-Evans rats were exposed to acute microinfusions (6microg/microl) of PKC-gamma antisense oligodeoxynucleotide (AS-ODN), control oligodeoxynucleotide (C-ODN) or vehicle into the NAcc at 24 and 3h before each training session. Behavioral findings showed that the blockade of NAcc-PKC-gamma translation caused impairments in the early phase of learning and retention of spatial information. Biochemical experiments showed that PKC-gamma expression was reduced and Ca(2+)/phospholipid-dependent protein kinase C (PKC) activity was blocked significantly in the AS-ODN-treated rats in comparison with control rats. The present findings suggest that NAcc-PKC-gamma plays a role during the early acquisition of spatial learning. Also, retention test results suggest that NAcc-PKC-gamma may be working as an intermediate factor involved in the onset of molecular mechanisms necessary for spatial memory consolidation within the NAcc. 相似文献
82.
The generality of working memory capacity: a latent-variable approach to verbal and visuospatial memory span and reasoning 总被引:12,自引:0,他引:12
Kane MJ Hambrick DZ Tuholski SW Wilhelm O Payne TW Engle RW 《Journal of experimental psychology. General》2004,133(2):189-217
A latent-variable study examined whether verbal and visuospatial working memory (WM) capacity measures reflect a primarily domain-general construct by testing 236 participants in 3 span tests each of verbal WM. visuospatial WM, verbal short-term memory (STM), and visuospatial STM. as well as in tests of verbal and spatial reasoning and general fluid intelligence (Gf). Confirmatory' factor analyses and structural equation models indicated that the WM tasks largely reflected a domain-general factor, whereas STM tasks, based on the same stimuli as the WM tasks, were much more domain specific. The WM construct was a strong predictor of Gf and a weaker predictor of domain-specific reasoning, and the reverse was true for the STM construct. The findings support a domain-general view of WM capacity, in which executive-attention processes drive the broad predictive utility of WM span measures, and domain-specific storage and rehearsal processes relate more strongly to domain-specific aspects of complex cognition. 相似文献
83.
This study used midazolam-induced amnesia to explore the plausibility of the estimates provided by the process dissociation procedure (PDP), which is designed to estimate the contributions of recollection (R) and automatic (A) processes to implicit memory performance. In a double-blind, placebo-controlled, within-subject design with 24 participants, single midazolam doses were administered intravenously, and word stem completion performance was used to calculate PDP estimates. A dissociation was observed such that midazolam decreased R but increased A estimates relative to placebo. Given that a manipulation that induces amnesia would not be expected to facilitate a memory process, these results add to the accumulating body of evidence suggesting that PDP estimates are not always theoretically plausible. Such evidence raises important questions about the use of the PDP. 相似文献
84.
Much has been stated in the popular press about the effects of the events of 9/11/01 on employee attitudes about work. This study examined a large sample (N = 70,671) of employees of a multinational manufacturer whose annual employee survey data collection was interrupted by the events. After demonstrating measurement equivalence across time and countries, changes in attitudes pre- and post-9/11 were examined. Only negligible differences were found in Job Satisfaction, Supervisor Evaluation, Stress, and Organizational Commitment to Diversity for U.S. employees or for employees worldwide. Demographic differences in response to events were not found. Implications for understanding effects of stressful external events on employee perceptions of work are discussed. 相似文献
85.
We studied perception in three patients with prosopagnosia of childhood onset. All had trouble with other 'within-category' judgments. All were deficient on face matching tests and severely impaired on tests of perception of the spatial relations of facial features and abstract designs, indicating a deficit in the encoding of coordinate relationships, similar to adult-onset prosopagnosia with lesions of the fusiform face area. Two had difficulty perceiving feature colour, which correlated with reduced luminance sensitivity. In contrast to adult-onset patients, saturation discrimination was spared in two and spatial resolution impaired in two. Curvature discrimination was relatively spared. Contrast sensitivity showed variable reductions at different spatial frequencies. We conclude that developmental prosopagnosia is similar to the adult-onset form in encoding deficits for the spatial arrangement of facial elements. Deficits in luminance perception and spatial resolution are more associated with defective encoding for basic object-level recognition, as shown on tests of object and spatial perception. 相似文献
86.
The notion that visual attention can operate over visual objects in addition to spatial locations has recently received much empirical support, but there has been relatively little empirical consideration of what can count as an 'object' in the first place. We have investigated this question in the context of the multiple object tracking paradigm, in which subjects must track a number of independently and unpredictably moving identical items in a field of identical distractors. What types of feature clusters can be tracked in this manner? In other words, what counts as an 'object' in this task? We investigated this question with a technique we call target merging: we alter tracking displays so that distinct target and distractor locations appear perceptually to be parts of the same object by merging pairs of items (one target with one distractor) in various ways - for example, by connecting item locations with a simple line segment, by drawing the convex hull of the two items, and so forth. The data show that target merging makes the tracking task far more difficult to varying degrees depending on exactly how the items are merged. The effect is perceptually salient, involving in some conditions a total destruction of subjects' capacity to track multiple items. These studies provide strong evidence for the object-based nature of tracking, confirming that in some contexts attention must be allocated to objects rather than arbitrary collections of features. In addition, the results begin to reveal the types of spatially organized scene components that can be independently attended as a function of properties such as connectedness, part structure, and other types of perceptual grouping. 相似文献
87.
In the present study, the authors examined differences in brain activity, as measured by amplitudes and latencies of event related potentials (ERP) components, in Hebrew-speaking adult dyslexic and normal readers when processing sentence components with different grammatical functions. Participants were 20 dyslexic and 20 normally reading male college students aged 18-27 years. The authors examined the processing of normal word strings in word-by-word reading of sentences having subject-verb-object (SVO) syntactic structure in self- and fast-paced conditions. Data revealed that in both reading conditions, the N100 and P300 ERP components were sensitive to internal processes such as recognition of words' grammatical functions. However, the results revealed that fast-paced reading rate might affect this process, as was reflected in the systematic changes of amplitudes and latencies of both ERP components. In accelerated reading, a significant decrease of latencies and increase of amplitudes in dyslexics were shown. It was also found that influence of fast-paced reading rate was realized in the full usage of the word-order strategy in sentence processing. In turn, this fact confirmed the hypothesis concerning a syntactic processing "weakness" in dyslexia. 相似文献
88.
Currently there are disputes in the infancy literature concerning when infants are first able to individuate physical objects by their features or properties. This issue has taken on new significance following claims that individuation by feature is linked to the emergence of object kind concepts toward the end of the first year. Needham (2001, this issue) presents evidence that infants as young as 4.5 months old can individuate objects by feature. We locate this controversy within the framework of brain mechanisms that index or track individual objects, drawing upon theories of attention and working memory developed in the study of adults. We find that Needham's work contributes to two issues: categorization and the effect of object history on the individuation of objects in a complex display. 相似文献
89.
Aucone EJ Wagner EE Raphael AJ Golden CJ Espe-Pfeifer P Dornheim L Seldon J Pospisil T Proctor-Weber Z Calabria M 《Assessment》2001,8(3):351-353
This study assesses the test-retest reliability of the revised Advanced Psychodiagnostic Interpretation (API) scoring system for the Bender Gestalt Test (BGT). The API system identifies 207 possible distortions in a BGT protocol. Test-retest reliability for 40 schizophrenic patients tested twice with a mean interval of 6.4 years (SD=3.8 years) was good, ranging from .71 to .80. Further reliability and validity studies are needed to further demonstrate the effectiveness of the system. 相似文献
90.
Making external attributions for negative events, though often considered “self-serving,” also implies that the attributor is not in control of critical resources. We hypothesized that making external attributions for negative events will lead to impressions of powerlessness. Because individuals in high-status roles are expected to have power and control, external attributions may violate these role expectations; thus, we further hypothesized that status would moderate the relationship between attributions and interpersonal outcomes. Specifically, more negative impressions and affect will be directed toward high-status individuals who make external attributions than toward their lower status counterparts. Three studies were conducted, one using a role-play methodology, one using an experimentally created hierarchy, and one using vignettes. The results supported our hypotheses: external attributions can be highly disserving for people in high-status positions. 相似文献