Working and long-term memory deficits in schizophrenia: is there a common prefrontal mechanism?

This study tested the hypothesis that dorsolateral prefrontal cortex deficits contribute to both working memory and long-term memory disturbances in schizophrenia. It also examined whether such deficits were more severe for verbal than nonverbal stimuli. Functional magnetic resonance imaging was used to assess cortical activation during performance of verbal and nonverbal versions of a working memory task and both encoding and recognition tasks in 38 individuals with schizophrenia and 48 healthy controls. Performance of both working memory and long-term memory tasks revealed disturbed dorsolateral prefrontal cortex activation in schizophrenia, although medial temporal deficits were also present. Some evidence was found for more severe cognitive and functional deficits with verbal than nonverbal stimuli, although these results were mixed.     

Physical activity,motor ability,and school readiness of 6-yr.-old children

The aim of this investigation was to study the relationships between physical activity, motor ability, and school readiness in 6-yr.-old children. In total, 294 healthy children from Tartu were studied (161 boys and 133 girls). The physical activity of children was reported by parents and teachers using the questionnaire of Harro. The motor ability of children was evaluated using various tests from the Eurofit test battery as well as the 3-min. endurance shuttle run test. The Controlled Drawing Observation rest was used as a predictor of school readiness and development of mental abilities. Indoor physical activities predicted 19-25% of total variance in motor scores for these preschool children. Motor ability tests, which demand children's total attention and concentration, appear related to the chosen measures of school readiness.     

An examination of the response styles theory of depression in third- and seventh-grade children: a short-term longitudinal study

The goal of this study was to test the response styles theory of depression in a sample of 3rd- and 7th-grade children. In addition, we examined whether the relationship between rumination and increases in depressive symptoms is mediated by hopelessness and low self-esteem. The procedure involved an initial assessment in which depressive symptoms, response styles, hopelessness, and self-esteem were assessed. The procedure also involved a follow-up assessment, 6 weeks later, in which depressive symptoms, hopelessness, and self-esteem were reassessed. Children with a ruminative response style exhibited increases in depressive symptoms over the 6-week period. In addition, the relationship between rumination and increases in depressive symptoms was mediated by both hopelessness and low self-esteem. Last, contrary to our hypotheses, neither distraction nor problem-solving response styles predicted decreases in depressive symptoms over the course of the study.     

Object-based selection operates on a grouped array of locations

In two experiments, space- and object-based selection effects were investigated, using variants of the ring-cuing paradigm of Egly and Homa (1984). The results revealed significant cuing modulation for nonring configurations of target locations spanning a range of retinal eccentricities, with the cuing effects independent of eccentricity and confined to the configuration of locations (rather than extending to locations within the space enclosed by the cued configuration). These results are consistent with object-based selection operating on a grouped spatial array (Vecera & Farah, 1994). Object selection may be based on a supradimensional saliency map representation of the field, modulated by feature-specific segmentation mechanisms (e.g., an object may be made salient on the basis of its color). Complex objects may be represented by grouped saliency signals. In this way, a two-dimensional spatial (saliency) representation may provide the common format for object-based selection, prior to full object definition.     

n-Variable Bisection

This paper deals with the measurement problem of deriving an overall evaluation of stimuli by n-component bisection. Reflexivity and a generalised form of bisymmetry for two variables will be shown to characterise n-component bisection in terms of quasilinear means, unique up to linear transformations of their generating functions. Copyright 2000 Academic Press.     

Brain Potentials in the Processing of Complex Sentences: An ERP Study of Control and Raising Constructions

In the present study we made use of Event-Related Potentials (ERPs) to examine raising and subject control constructions in German. Our most salient result is that the ERPs elicited at the empty subject position of a raising construction are clearly different from those elicited at the corresponding position of an otherwise identical subject control construction, the former producing a stronger P600. We argue that this result provides an electrophysiological correlate of the theoretical distinction between NP trace and PRO.     

Vagus nerve stimulation: a new form of therapeutic brain stimulation

Although the vagus nerve has traditionally been considered to perform efferent functions, in reality it performs significant afferent functions as well, carrying information from the body, head, and neck to the brain. Preliminary studies examining this afferent activity led to the theory that vagus nerve stimulation (VNS) could successfully control seizure activity in persons who are refractory to antiepileptic medications. Unlike other forms of brain stimulation, VNS is unable to directly stimulate multiple discrete areas of the brain; however, through several pathways, it is able to relay sensory information to higher brain regions. An implantable VNS device known as the VNSTM NeuroCybernetic Prosthesis (NCP) System has been used in approximately 9,000 epilepsy patients in Europe and the United States since 1994. The implant has reduced seizure frequency by an average of 25% to 30%, with minimal side effects. Studies underway are also showing some degree of success in the management of treatment-refractory depression. The future efficacy of the implantable system in other disorders may depend on whether the implant can be more precisely focused to affect different brain regions. Research in this area is underway.     

Implicit and explicit learning of event sequences: evidence for distinct coding of perceptual and motor representations

Event-related brain potentials (ERPs) of 21 subjects were recorded in a choice reaction time task with a repeating eight-element long stimulus sequence. The regular event sequence was sometimes interrupted by 'perceptual' or by 'motor deviants' which both replaced an expected stimulus but either preserved or violated the sequence of motor responses. Response times confirmed that all subjects had acquired some knowledge of the sequential dependencies. By means of a post-experimental free recall and recognition test, subjects were classified as having either explicit or implicit knowledge of the event sequence. The ERPs showed different effects for different types of stimuli and the two groups. In the group of explicit learners, a larger N200 component was evoked by both types of deviants and a larger P300 by motor deviants only. In the group of implicit learners these 'perceptual components' remained unaffected. In contrast, in both groups of subjects the lateralized readiness potential (LRP) which accompanied motor deviants revealed a partial activation of the to be expected but incorrect response, i.e. motor learning. These results suggest that explicit learners acquire knowledge about both, stimulus and response dependencies while implicit learners acquire knowledge about response dependencies only.     

Mean response times, variability, and skew in the responding of ADHD children: a response time distributional approach

Response time (RT) distributions from three fixed foreperiod conditions (2, 4, and 8 s) in a warned four-choice RT task were obtained for a group of boys with attention-deficit/hyperactivity disorder, combined type (ADHD; n = 17) and for two groups of normal control boys (age-matched, n = 18, and younger-aged, n = 10). Quantitative measures of distributional shape were derived by fitting the ex-Gaussian distributional model to the individual RT data. Statistical results indicate that the ADHD distributions differ from the age-matched control distributions with respect to the size of the tail (larger for the ADHD boys), but differ from the younger control distributions with respect to the location of the leading edge (slower for the younger control boys). Receiver operating characteristic (ROC) results reveal that the ex-Gaussian exponential component is highly diagnostic of the ADHD boys.     

Family perception of interpersonal behavior as a predictor in eating disorders: a prospective, six-year followup study

This study assessed family perception patterns of interpersonal behavior in families with a daughter diagnosed with an eating disorder 6 years after treatment that used a prospective design. Family perception patterns of patients found to have a poor outcome at followup (n = 15) were compared with patients with a good outcome (n = 23), as well as a control group (n = 36). Using the system of multiple level observation of groups (SYMLOG), all 238 family members evaluated themselves and each other. The index patients with a poor outcome perceived themselves as friendlier and more positive than they were perceived by their families. In comparison to parents of daughters with a good outcome and the control group, parents of daughters in the poor outcome group perceived themselves to be less friendly than their partners perceived them to be. A rigid polarization of the perception of the index patient by family members and a discrepancy in this perception between the index patient and the rest of the family were found to be indicative of a poor prognosis. Implications for treatment based on family perception patterns of interpersonal behavior are discussed.