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排序方式： 共有204条查询结果，搜索用时 15 毫秒
41.
Eric R. A. Y. Detrait Étienne Hanon Bertrand Dardenne Yves Lamberty 《Behavior research methods》2009,41(3):805-811
In the present article, we describe a new protocol for the inhibitory avoidance test, with a dual purpose: (1) to provide a leß variable and more reliable aßeßment of the efficacy of potential cognitive enhancers in antagonizing scopolamine-induced long-term-memory deficits, and (2) to secure a high throughput for pharmacological screening of cognitive enhancers. The new protocol consists of two acquisition trials that are followed 24 h later by a single retention trial. In the present study, this protocol clearly dißociated the frequency distributions of retention latencies between scopolamine- and vehicle-treated groups and allowed validation by means of two acetylcholinesterase inhibitors—tacrine and donepezil—that proved to be active in counteracting the scopolamine-induced memory deficit. This protocol also produced stability of the behavioral response to pharmacological agents over a 3-year period. A statistical power analysis indicated that, depending on the efficacy of the drug/dose, a sample size of 5–12 mice was required in order to show a reversal of the scopolamineinduced memory deficit. The double-trial acquisition protocol is suitable for testing cognitive enhancers, while also providing a clearly enhanced throughput. 相似文献
42.
Yves de Maeseneer 《Modern Theology》2003,19(4):511-527
In search for a European theological contribution to the debate on the new global context, this essay undertakes a theological‐aesthetic exploration of theological motifs in the current political imagination, in particular: the theme of the angel. After a problematisation of the theological reception of Benjamin's Messianic‐apocalyptic angel figure, I develop a critical position in the wake of von Balthasar. Von Balthasar's interpretations of Rilke and Bonaventure lead to two angelological paradigms, the monad and the crucified seraph, which occur in current political debates, as exemplified in recent essays of Zizek. 相似文献
43.
44.
Maria T. Barendse Yves Rosseel 《The British journal of mathematical and statistical psychology》2023,76(2):327-352
Pairwise maximum likelihood (PML) estimation is a promising method for multilevel models with discrete responses. Multilevel models take into account that units within a cluster tend to be more alike than units from different clusters. The pairwise likelihood is then obtained as the product of bivariate likelihoods for all within-cluster pairs of units and items. In this study, we investigate the PML estimation method with computationally intensive multilevel random intercept and random slope structural equation models (SEM) in discrete data. In pursuing this, we first reconsidered the general ‘wide format’ (WF) approach for SEM models and then extend the WF approach with random slopes. In a small simulation study we the determine accuracy and efficiency of the PML estimation method by varying the sample size (250, 500, 1000, 2000), response scales (two-point, four-point), and data-generating model (mediation model with three random slopes, factor model with one and two random slopes). Overall, results show that the PML estimation method is capable of estimating computationally intensive random intercept and random slopes multilevel models in the SEM framework with discrete data and many (six or more) latent variables with satisfactory accuracy and efficiency. However, the condition with 250 clusters combined with a two-point response scale shows more bias. 相似文献
45.
Neglect is the most prevalent form of maltreatment, but it has been understudied relative to abuse. Additionally, developmental outcomes associated with early maternal withdrawal have been understudied relative to outcomes associated with harsh treatment. However, a large body of studies on rodents has documented the causal effect of low maternal care on altered stress responses in offspring. Other evidence from human studies links early maternal withdrawal to clinical levels of neglect. Studies of both rodents and humans suggest that, rather than the aversive responses (e.g., fight, flight, freeze) modeled in relation to threat of attack or harsh treatment, early maternal withdrawal is associated with increased calling and contact seeking to mothers. Moreover, two longitudinal studies indicate that early maternal withdrawal, but not negative-intrusive interaction, contributes to adolescent borderline psychopathology. The field needs prospective studies with well-operationalized constructs of maternal withdrawal to delineate the distinct developmental pathways that may be associated with neglect. 相似文献
46.
This paper examines the application of the guidelines for evidence‐based treatments in family therapy developed by Sexton and collaborators to a set of treatment models. These guidelines classify the models using criteria that take into account the distinctive features of couple and family treatments. A two‐step approach was taken: (1) The quality of each of the studies supporting the treatment models was assessed according to a list of ad hoc core criteria; (2) the level of evidence of each treatment model was determined using the guidelines. To reflect the stages of empirical validation present in the literature, nine models were selected: three models each with high, moderate, and low levels of empirical validation, determined by the number of randomized clinical trials (RCTs). The quality ratings highlighted the strengths and limitations of each of the studies that provided evidence backing the treatment models. The classification by level of evidence indicated that four of the models were level III, “evidence‐based” treatments; one was a level II, “evidence‐informed treatment with promising preliminary evidence‐based results”; and four were level I, “evidence‐informed” treatments. Using the guidelines helped identify treatments that are solid in terms of not only the number of RCTs but also the quality of the evidence supporting the efficacy of a given treatment. From a research perspective, this analysis highlighted areas to be addressed before some models can move up to a higher level of evidence. From a clinical perspective, the guidelines can help identify the models whose studies have produced clinically relevant results. 相似文献
47.
Yves R. F. Guillaume Jeremy F. Dawson Vincenza Priola Claudia A. Sacramento Stephen A. Woods Helen E. Higson 《European Journal of Work and Organizational Psychology》2013,22(5):783-802
The literature on policies, procedures, and practices of diversity management in organizations is currently fragmented and often contradictory in highlighting what is effective diversity management, and which organizational and societal factors facilitate or hinder its implementation. In order to provide a comprehensive and cohesive view of diversity management in organizations, we develop a multilevel model informed by the social identity approach that explains, on the basis of a work motivation logic, the processes by, and the conditions under which employee dissimilarity within diverse work groups is related to innovation, effectiveness, and well-being. Building on this new model, we then identify those work group factors (e.g., climate for inclusion and supervisory leadership), organizational factors (e.g., diversity management policies and procedures, and top management's diversity beliefs), and societal factors (e.g., legislation, socioeconomic situation, and culture) that are likely to contribute to the effective management of diversity in organizations. In our discussion of the theoretical implications of the proposed model, we offer a set of propositions to serve as a guide for future research. We conclude with a discussion of possible limitations of the model and practical implications for managing diversity in organizations. 相似文献
48.
Pioneer experiments on saccadic suppression have shown that this effect is not followed by motor disorientation: Conscious perception of a target displacement can be dissociated from correct manual target reaching. It has subsequently been demonstrated that movement corrections with the same latency and spatial characteristics can be produced in conditions allowing perceptual awareness of perturbation of a target as in condition inducing saccadic suppression. In addition to the qualitative dissociation between motor performance and conscious awareness, quantitative temporal dissociations in action can be observed by manipulating different features of the visual target. When the target of an ongoing simple action is perturbed, a temporal advantage is found for responses to perturbations of location relative to colour and shape. Furthermore, there seems to be a temporal advantage for automatic motor corrections made in response to a target displacement as compared to other responses (other ongoing movement adjustments, movement interruption, conditional motor response such as pressing a key, verbal response, delayed matching-to-sample tasks). Thus, this paper reviews evidence for the fact that the temporal characteristics of any given response to a stimulus are dependent both on the sensory processes and on the type of response generated. Accordingly, identification responses (such as verbal report) to a visual stimulus are much slower than motor corrections of an ongoing movement in response to a target location change because of different processing times of the stimulus features (“What” compared to “Where”) and of the response itself (“What” compared to “How”). The existence of two continua (What/Where and What/How) is proposed between these two extreme stimulus- response combinations. This model may be a useful framework to better understand visuo-motor transformations and the network of connections between visual and motor areas. 相似文献
49.
Martial Van der Linden Michel Hupet Pierre Feyereisen Marie-Anne Schelstraete Yves Bestgen Raymond Bruyer 《Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition》2013,20(1):32-55
The present study tried to specify how much processing speed, working memory capacity, and inhibition capability contribute to the effects of aging on language performance. An individual-differences approach was used to examine the component processes that predict performance in language comprehension and verbal long-term memory tasks. A total of 151 participants aged 31-80 completed language processing tasks and a battery of tasks designed to assess processing speed, working memory, and resistance to interference. Latent-construct structural equation modeling was used to examine the relationships of these factors and age to different types of language tasks. The best fit model showed first that all the significant relationships between age and language performance are mediated through reductions in speed, resistance to interference, and working memory; this confirms the validity of the general factor approach of age-related differences in cognitive performance. The best fit model, however, also showed that the contribution of speed and resistance to interference is indirect and mediated by working memory, which appears to play a crucial role in explaining age-related differences in language performance. 相似文献
50.