Minds, persons, and space: an fMRI investigation into the relational complexity of higher-order intentionality

Mental state reasoning or theory-of-mind has been the subject of a rich body of imaging research. Although such investigations routinely tap a common set of regions, the precise function of each area remains a contentious matter. With the help of functional magnetic resonance imaging (fMRI), we sought to determine which areas are involved when processing mental state or intentional metarepresentations by focusing on the relational aspect of such representations. Using non-intentional relational representations such as spatial relations between persons and between objects as a contrast, the results ascertained the involvement of the precuneus, the temporal poles, and the medial prefrontal cortex in the processing of intentional representations. In contrast, the anterior superior temporal sulcus and the left temporo-parietal junction were implicated when processing representations that refer to the presence of persons in relational contexts in general. The right temporo-parietal junction, however, was specifically activated for persons entering spatial relations. The level of representational complexity, a previously unexplored factor, was also found to modulate the neural response in some brain regions, such as the medial prefrontal cortex and the right temporo-parietal junction. These findings highlight the need to take into account the critical roles played by an extensive network of neural regions during mental state reasoning.     

Contribution of NIRS to the study of prefrontal cortex for verbal fluency in aging

Healthy aging is characterized by a number of changes on brain structure and function. Several neuroimaging studies have shown an age-related reduction in hemispheric asymmetry on various cognitive tasks, a phenomenon captured by Cabeza (2002) in the Hemispheric Asymmetry Reduction in Older Adults (HAROLD) model. Although this phenomenon is supported by a range of neuroimaging data on memory and inhibitory processes, there is little evidence concerning changes in hemispheric asymmetry for language processing, and particularly word retrieval, which is assessed with verbal fluency task (VFT). This study aimed to investigate the age-related changes in cerebral oxygenation in the prefrontal cortex for both letter and category VFT, varying the complexity of the criteria (i.e., degree of productivity) and using near-infrared spectroscopy (NIRS). Sixteen younger and 16 older adults participated in this study. For both VF conditions, participants were instructed to pronounce as many nouns as possible as a function of high-productivity (e.g., “animals” or “L”) or low-productivity (e.g., “flowers” or “V”) criteria. Behavioral data (i.e., accuracy responses) showed comparable performance in younger and older adults for both VF conditions. However, NIRS data showed more reduced activation (i.e., significantly reduced increase in [O₂Hb] and reduced decrease in [HHb]) in older than younger adults for both VFT. In addition, a bilateral effect was found for both groups, suggesting that VFT requires both executive and language functions. The results are discussed in the context of the current theories of aging.     

Stimulus congruence and stimulus-response compatibility: Two variables disentangled in an auditory reaction time task

Abstract

Stimulus—response (S-R) compatibility was a tem fmt used by Wtts and Seeger (1953) to describe effcts observed on reaction time (RT) when the stimulus—response relationship was varied, as in the following instructions: “move to tbe right when the stimulus appears on the right” (compatible) or “move to the left when the stimulus appears on the right” (incompatible). This term was later employed in a broader sense (Simon & Rudell, 1967) with paradigms involving elaborate stimuli, such as the verbal command ‘RIGHT’ delivered to the right tar (compatible) or to the left ear (incompatible). In such paradigms. subjects respond faster when the response is delivered on the same side as the stimulus (the so-called “Simon effect”). It has been shown, however, that this effect could be reversed under some circumstanas in the visual domain. In this paper, we report data showing that it can also be reversed in the auditory domain when using the above-mentioned verbal commands. This brings further evidence that stimulus-response compatibility and the Simon effect difier in essence, with the latter effect reflecting the influence of stimulus congruence, the correspondence relationship borne by the two simultaneous characteristics of the stimulus. Stimulus congruence and stimulus-response compatibility had indeed independent influences on RT, which in a serially connected information-processing modcl would imply that they act upon independent stages.     

Insensitivity of visual short-term memory to irrelevant visual information

Several authors have hypothesized that visuo-spatial working memory is functionally analogous to verbal working memory. Irrelevant background speech impairs verbal short-term memory. We investigated whether irrelevant visual information has an analogous effect on visual short-term memory, using a dynamic visual noise (DVN) technique known to disrupt visual imagery (Quinn & McConnell, 1996b). Experiment 1 replicated the effect of DVN on pegword imagery. Experiments 2 and 3 showed no effect of DVN on recall of static matrix patterns, despite a significant effect of a concurrent spatial tapping task. Experiment 4 showed no effect of DVN on encoding or maintenance of arrays of matrix patterns, despite testing memory by a recognition procedure to encourage visual rather than spatial processing. Serial position curves showed a one-item recency effect typical of visual short-term memory. Experiment 5 showed no effect of DVN on short-term recognition of Chinese characters, despite effects of visual similarity and a concurrent colour memory task that confirmed visual processing of the characters. We conclude that irrelevant visual noise does not impair visual short-term memory. Visual working memory may not be functionally analogous to verbal working memory, and different cognitive processes may underlie visual short-term memory and visual imagery.     

THE IMAGO DEI: EVOLUTIONARY AND THEOLOGICAL PERSPECTIVES

This short article provides an introduction to a special section, consisting of six papers on human evolution and the imago Dei. These papers are the result of dialogue between theologians and philosophers of religion at the University of Oxford and the Catholic University of Leuven. All contributors focus on the imago Dei, and consider how this theological notion can be understood from an evolutionary perspective, looking at a variety of disciplines, including the psychology of reasoning, cognitive science of religion, paleoanthropology, evolutionary psychology, and evolutionary ethics.     

Computation and application of generalized linear mixed model derivatives using lme4

Psychometrika - Maximum likelihood estimation of generalized linear mixed models (GLMMs) is difficult due to marginalization of the random effects. Derivative computations of a fitted GLMM’s...     

Improvement of mental imagery after prism exposure in neglect: a case study

Previous work has shown that various symptoms of unilateral neglect, including the pathological shift of the subjective midline to the right, may be improved by a short adaptation period to a prismatic shift of the visual field to the right. We report here the improvement of imagined neglect after prism exposure in a patient with a left unilateral neglect. Despite a strong neglect observed for mental images as well as for conventional tests, the mental evocation of left-sided information from an internal image of the map of France map was fully recovered following prism adaptation to the right. This improvement could not be explained by the alteration of visuomotor responses induced by the prism adaptation. Prism adaptation may therefore act not only on sensory-motor levels but also on a higher cognitive level of mental space representation and/or exploration.