Neurobiological Markers of Illness Onset in Psychosis and Schizophrenia: The Search for a Moving Target

In this review, we describe neuropsychological and brain imaging findings in the early stages of psychosis and schizophrenia. We focus on recent clinical high-risk studies and consider whether the evidence supports these as ‘endophenotypes’ of a vulnerability to the illness or as ‘biomarkers’ of illness onset and transition. The findings suggest that there are a number of processes at psychosis onset that may represent biomarkers of incipient illness. These neurobiological indices particularly implicate the integrity of frontal and temporal cortices, which may or may not be related to the genetics of psychosis (i.e. potential ‘endophenotypes’). However, these brain regions are dynamically changing during normal maturation, meaning that any putative neurobiological markers identified at the earliest stages of illness may be relatively unstable. We suggest that, while such measures may be readily identified as potential neurobiological markers of established illness, they are inconsistent at (or around) the time of illness onset when assessed cross-sectionally. Instead, identification of more valid risk markers may require longitudinal assessment to ascertain normal or abnormal trajectories of neurodevelopment. Accordingly, we assert that the current conceptualisations of potential biomarkers and/or ‘endophenotypes’ for schizophrenia may need to be reconsidered in the context of normal and abnormal brain maturational processes at the time of onset of psychotic disorders.     

集权的道德哲学反思

集权是以功利目的论为理论根基,以"例外特质"为道德心理基础,以独断的道德相对论和独断的道德一元论的不良混合为道德特征,以暴力和强制为后盾的不道德的特殊权利.集权践踏人权、违背人性,不配享有权利之名,因而是必须祛除的对象.     

Both exogenous and endogenous target salience manipulations support resource depletion accounts of the attentional blink: A reply to Olivers, Spalek, Kawahara, and Di Lollo (2009)

Input control theories of the attentional blink (AB) suggest that this deficit results from impaired attentional selection caused by the post-Target 1 (T1) distractor (Di Lollo, Kawahara, Ghorashi, & Enns, 2005; Olivers, van der Stigchel, & Hulleman, 2007). Accordingly, these theories predict that there should be no AB when no distractors intervene between the targets. Contrary to these hypotheses, Dux, Asplund, and Marois (2008) observed an AB (T3 deficit) when three targets, from the same attentional set, were presented successively in a rapid stream of distractors, if subjects increased the resources they devoted to T1 processing. This result is consistent with resource depletion accounts of the AB. However, Olivers, Spalek, Kawahara, and Di Lollo (2009) argue that Dux et al.’s results can be better explained by the relationship between T1 and T2, and by target discriminability effects, rather than by the relationship between T1 and T3. Here, we find that manipulating the resources subjects devote to T1, either exogenously (target perceptual salience) or endogenously (target task relevance), affects T3 performance, even when T2 and target discriminability differences are controlled for. These results support Dux et al.’s conclusion that T1 resource depletion underlies the AB.     

How representationalism can account for the phenomenal significance of illumination

In this paper, I defend a representationalist account of the phenomenal character of color experiences. Representationalism, the thesis that phenomenal character supervenes on a certain kind of representational content, so-called phenomenal content, has been developed primarily in two different ways, as Russellian and Fregean representationalism. While the proponents of Russellian and Fregean representationalism differ with respect to what they take the contents of color experiences to be, they typically agree that colors are exhaustively characterized by the three dimensions of the color solid: hue, saturation, and lightness. I argue that a viable version of representationalism needs to renounce this restriction to three dimensions and consider illumination to be a genuine phenomenal dimension of color. My argument for this thesis falls into two parts. I first consider the phenomenon of color constancy in order to show that neither Russellian nor Fregean representationalism can do justice to the phenomenal significance of local illumination. I subsequently formulate a version of representationalism that accounts for illumination by taking it as a phenomenal dimension of color.     

句子语境中汉语词汇歧义消解的ERP研究

采用ERP方法,考察了汉语词汇歧义消解中句子语境作用的时间进程及大脑活动。目标词与句子语境存在一致、不一致、无关控制等3种关系。结果显示:(1)一致与不一致条件下N400的平均波幅均显著低于无关控制条件;(2)SOA为200毫秒时产生的N400平均波幅的幅度显著高于SOA为1000毫秒的条件;(3)N400的平均波幅及潜伏期均表现出左半球显著高于右半球的特点。实验结果支持词汇歧义消解的模块化观点,体现了大脑两半球语言功能的不对称性。     

组织学习动力研究

本文以协调博弈原理为基础,系统分析了组织学习中微观个体层面和宏观组织层面的学习动力性质和相互关系,尝试提出了刻画宏观组织层面学习动力状态的理论和方法,并据此建立了协调组织学习动力的三维整合模型。     

Self‐ambivalence and reactions to success versus failure

People differ in the extent to which their self‐evaluations fluctuate in response to positive and negative events. This research tests whether self‐ambivalence predicts this self‐evaluative reactivity. Participants first completed measures of self‐ambivalence and baseline self‐esteem. Next, they were induced a success or failure experience in a cognitive task and finally rated their cognitive self‐evaluations (task‐specific ability, state self‐esteem) and affective reactions (self‐feelings, mood). Self‐ambivalence was associated with stronger effects of the success/failure manipulation on cognitive self‐evaluations but not on affective reactions, with baseline self‐esteem controlled. Possible underlying mechanisms are discussed. Copyright © 2006 John Wiley & Sons, Ltd.     

Being Admired or Being Liked: Classroom Social Status and Depressive Problems in Early Adolescent Girls and Boys

This study investigates associations between depressive problems and classroom social status in a large population cohort of Dutch early adolescents (N = 1046, age 13.52 +/- 0.51, 52.4% girls). Depressive problems were assessed by parent and self-reports and classroom status by peer nominations. We assessed peer status with respect to both achievement-related (being a good learner, being good at sports, being good-looking) and affection-related (being liked, being disliked, being best friend) areas. In boys, depressive problems were most strongly associated with not being good at sports, while in girls the association was strongest for not being liked. The risk of a low status in one area could largely be compensated by a high status in another area.     

动机的结构与效应：基于动机连续体的视角

动机连续体是对内部动机、外部动机进行整合的心理学概念,其对内部动机和外部动机的争论提出了不同的假设。从大理论(grand theory)视角出发,对涉及上述两个概念的理论进行梳理,将自我决定理论与其他相关理论进行整合。由此展开对内部动机、外部动机结构的讨论,总结了动机的单维结构、多维结构和复杂结构假设下的理论新进展,分别论述在拮抗效应、累加效应和其他复杂效应等假设下动机对结果变量的影响,并展开不同效应对实践应用的讨论。     

Are All Kids Alike? The Magnitude of Individual Differences in Personality Characteristics Tends to Increase from Early Childhood to Early Adolescence

Do individual differences in personality traits become more or less pronounced over childhood and adolescence? The present research examined age differences in the variance of a range of personality traits, using parent reports of two large samples of children from predominantly the USA and Russia, respectively. Results indicate (i) that individual differences in most traits tend to increase with age from early childhood into early adolescence and then plateau, (ii) that this general pattern of greater personality variance at older childhood age is consistent across the two countries, and (iii) that this pattern is not an artefact of age differences in means or floor/ceiling effects. These findings are consistent with several (noncontradictory) developmental mechanisms, including youths' expanding behavioural capacities and person–environment transactions (corresponsive principle). However, these mechanisms may predominantly characterize periods before adolescence, or they may be offset by countervailing processes, such as socialization pressure towards a mature personality profile, in late adolescence and adulthood. Finally, the findings also suggest that interpreting age trajectories in mean trait scores as pertaining to age differences in a typical person may sometimes be misleading. Investigating variance should become an integral part of studying personality development. Copyright © 2017 European Association of Personality Psychology