视觉空间工作记忆组间差异的神经机制

为考察视觉空间工作记忆（working memory, WM）维持和操作的组间差异及其神经机制,本研究记录了高、低WM组完成延迟再认（维持）任务和心理旋转（操作）任务时的行为和事件相关电位数据。结果发现,在操作任务中,高WM组比低WM组的反应时显著更短;高WM组的中前额叶慢波显著更正、双侧后顶区慢波显著更负,并且两者的波幅显著负相关。在维持任务中,两组被试的反应时无显著差异;高WM组的中前额叶慢波显著更正。结果表明,高WM组的执行注意能力可能更强,能通过有效调节和分配加工资源来表征视觉信息。     

Evaluation and classification of types of Chinese handwriting deficits in elementary schoolchildren

The handwriting problems of elementary schoolchildren were investigated in this study. A questionnaire for evaluation of Chinese handwriting was developed and then administered to 165 children with handwriting deficits. Factor analysis indicated that the questionnaire has six major dimensions, including construction of characters, accuracy, developmental delay, pencil grip, gross movement, and emotional reaction. These six dimensions were utilized to search for subtypes of handwriting deficits. By further sampling, another 209 children were administered the handwriting evaluation questionnaire to classify their handwriting deficits. According to the severity of deficits on different dimensions of the questionnaire, K-means clustering was utilized to classify the children into four subtypes of mild, severe, motor-originated, and academic learning dysfunction subtypes. The classification by subtype might be helpful in planning interventions for children with handwriting deficits.     

A simple method to dissociate sensory-attentional and motor-intentional biases in unilateral visual neglect

A variant of a line bisection test was devised. Patients with unilateral visual neglect and control subjects were asked to perform the test, which consisted of two subtasks: a verbal and a manual task. The verbal task was newly designed and did not require manual responses from the subjects. The manual task was similar to conventional line bisection tasks. This paper reports and discusses the results obtained from each task and their correlations. This technique is compatible with bedside examinations, does not require a complex apparatus, and provides useful data for the assessment of unilateral visual neglect.     

Personality, psychopathology, and demographic correlates of medical vs behavioral reasons for referral in alcoholic men

The personality, psychopathological, and demographic differences between 330 alcoholic men referred for behavioral problems and 104 alcoholic men referred for medical problems were examined. The Minnesota Multiphasic Personality Inventory-2 indicated that those referred for behavioral problems showed more antisocial characteristics, while those referred for medical reasons had more subjective distress, were more highly introverted, and showed greater somatic preoccupation. Hispanic alcoholic men had a significantly higher proportion of medical referrals than Caucasian and African-American alcoholic men.     

Task-effector asymmetries in a rhythmic continuation task

Variability in rhythmic movements has been interpreted as a signature of internal or peripheral noise processes. Grounded in an oscillator interpretation, this study hypothesized that period variability and drift arises from the asymmetry between target period and the limb's intrinsic dynamics. Participants synchronized to 7 target periods, swinging 1 of 3 pendulums in a continuation paradigm; 3 periods were longer, 3 shorter, and 1 identical to the preferred period. Results supported 5 predictions: Drift toward the preferred period was observed that scaled with the asymmetry. Variability was lowest for symmetry conditions and increased with the asymmetry. Variability decreased concomitant with the approach toward the preferred period. Periods exponentially approached the preferred period with positive autocorrelations up to 10 cycles.     

Velocity dependence of the interocular transfer of dynamic motion aftereffects

It is well established that motion aftereffects (MAEs) can show interocular transfer (IOT); that is, motion adaptation in one eye can give a MAE in the other eye. Different quantification methods and different test stimuli have been shown to give different IOT magnitudes, varying from no to almost full IOT. In this study, we examine to what extent IOT of the dynamic MAE (dMAE), that is the MAE seen with a dynamic noise test pattern, varies with velocity of the adaptation stimulus. We measured strength of dMAE by a nulling method. The aftereffect induced by adaptation to a moving random-pixel array was compensated (nulled), during a brief dynamic test period, by the same kind of motion stimulus of variable luminance signal-to-noise ratio (LSNR). The LSNR nulling value was determined in a Quest-staircase procedure. We found that velocity has a strong effect on the magnitude of IOT for the dMAE. For increasing speeds from 1.5 deg s(-1) to 24 deg s(-1) average IOT values increased about linearly from 18% to 63% or from 32% to 83%, depending on IOT definition. The finding that dMAEs transfer to an increasing extent as speed increases, suggests that binocular cells play a more dominant role at higher speeds.     

辩证分析兴奋性氨基酸对神经细胞的双重作用

兴奋性氨基酸（ＥＡＡｓ） 广泛分布于中枢神经系统,参与多种生理过程包括学习、记忆和伤害感受等。然而,ＥＡＡｓ 受体的过度兴奋却可引发一系列细胞事件,最终导致神经元的损伤与死亡。许多神经退行性疾病如早老性痴呆、癫痫和肌侧索硬化症等都与ＥＡＡｓ 的兴奋毒作用有关。目前的研究表明,由ＥＡＡｓ 受体过度兴奋所引发的细胞内钙超载是导致神经元死亡的最终途径     

基于等级反应模型的规则空间方法

本研究基于Tatsuoka的规则空间方法, 对理想反应模式与异常反应指标进行了扩展, 推导了多级评分项目下规则空间方法的算法公式。在4种属性层级结构(发散型、收敛型、线型与无结构型)×4种“失误”作答概率(2%、5%、10%与15%)测验情境下, 以属性模式判准率、被试属性判准率、敏感性与特异性为指标, 检验了多级评分项目下规则空间方法的分类准确性。结果表明：(1) 基于多级评分项目构建的异常反应指标, 能有效地对被试进行分类与解释, 且0-1评分项目下异常反应指标及其性质都是多级评分下的特例; (2) 随着“失误”作答概率的增加, 4种属性层级结构的分类准确性都会降低; (3) 线型和收敛型的分类准确性明显好于发散型与无结构型; (4) 纯规则点的分布对规则空间方法的分类准确性有显著影响。     

A Bootstrapping Model of Frequency and Context Effects in Word Learning

Prior research has shown that people can learn many nouns (i.e., word–object mappings) from a short series of ambiguous situations containing multiple words and objects. For successful cross‐situational learning, people must approximately track which words and referents co‐occur most frequently. This study investigates the effects of allowing some word‐referent pairs to appear more frequently than others, as is true in real‐world learning environments. Surprisingly, high‐frequency pairs are not always learned better, but can also boost learning of other pairs. Using a recent associative model (Kachergis, Yu, & Shiffrin, 2012), we explain how mixing pairs of different frequencies can bootstrap late learning of the low‐frequency pairs based on early learning of higher frequency pairs. We also manipulate contextual diversity, the number of pairs a given pair appears with across training, since it is naturalistically confounded with frequency. The associative model has competing familiarity and uncertainty biases, and their interaction is able to capture the individual and combined effects of frequency and contextual diversity on human learning. Two other recent word‐learning models do not account for the behavioral findings.